Substituted [(phenylethanoyl)amino]benzamides

1. A compound of the formula

in which

Y is a bond, methanediyl, sulfur or oxygen;

R 1 is biphenyl-4-yl, where 1 to 3 carbon atoms in biphenyl-4-yl may be replaced by nitrogen,

or

R 1 is 1,3-benzodioxol-5-yl or 2,3-dihydro-1,4-benzodioxin-5-yl,

or

R 1 is a group of the formula

where

X is N, O or S,

* is the point of attachment to the carbon atom, and

the phenyl ring is linked via position 4 or 5 when the five-membered ring is linked via position 2 to the carbon atom, or the phenyl ring is linked via position 5 when the five-membered ring is linked via position 3 to the carbon atom,

or

R 1 is naphth-1-yl or naphth-2-yl, where 1 carbon atom in naphth-1-yl and naphth-2-yl may be replaced by nitrogen,

or

R 1 is a group of the formula

where

W is C or N,

V is N, O or S,

* is the point of attachment to the carbon atom, and

the group is linked via position 2, 3, 5 or 6 to the carbon atom,

or

R 1 is a group of the formula

where

U is N, O or S,

* is the point of attachment to the carbon atom, and

the group is linked via position 2, 3, 5 or 6 to the carbon atom,

where R 1 may be substituted by 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of hydroxy, amino, halogen, cyano, trifluoromethyl, trifluoromethoxy, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino, hydroxycarbonyl, C 1 -C 6 -alkoxycarbonyl, aminocarbonyl, C 1 -C 6 -alkylaminocarbonyl, C 1 -C 6 -alkylcarbonyl and C 1 -C 6 -alkylcarbonylamino;

R 2 is hydrogen, C 1 -C 6 -alkyl or C 3 -C 7 -cycloalkyl;

R 3 is C 3 -C 7 -cycloalkyl or optionally up to pentafluoro-substituted C 1 -C 4 -alkyl; and

R 7 is a group of the formula

where

* is the point of attachment to Y,

R 4 , R 5 and R 6 are independently of one another hydrogen, hydroxy, amino, halogen, cyano, trifluoromethyl, trifluoromethoxy, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino, C 3 -C 7 -cycloalkyl, 5- to 7-membered heterocyclyl, C 6 -C 10 -aryl, 5- or 6-membered heteroaryl, hydroxycarbonyl, C 1 -C 6 -alkoxycarbonyl, aminocarbonyl, C 1 -C 6 -alkylaminocarbonyl, C 1 -C 6 -alkylcarbonyl carbonyl, C 1 -C 6 -alkylaminocarbonyl, C 1 -C 6 -alkylcarbonyl or C 1 -C 6 -alkylcarbonylamino,

in which cycloalkyl, heterocyclyl, aryl and heteroaryl may be substituted by 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of hydroxy, amino, halogen, cyano, trifluoromethyl, trifluoromethoxy, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino, hydroxycarbonyl, C 1 -C 6 -alkoxycarbonyl, aminocarbonyl, C 1 -C 6 -alkylamino-carbonyl, C 1 -C 6 -alkylcarbonyl and C 1 -C 6 -alkylcarbonylamino,

or

R 4 and R 5 are linked to adjacent carbon atoms and form a —O—CH 2 —CH 2 —O-bridge,

or

R 7 is a 5- or 6-membered heteroaryl,

in which heteroaryl may be substituted by 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of hydroxy, amino, halogen, cyano, trifluoromethyl, trifluoromethoxy, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy and C 1 -C 6 -alkylamino;

or a salt thereof.

2. The compound as claimed in claim 1 , which corresponds to the formula

in which

Y is a bond or methanediyl;

R 1 is biphenyl-4-yl, 1,3-benzodioxol-5-yl, 2,3-dihydro-1,4-benzodioxin-5-yl, 5-phenylthien-2-yl, 5-phenylfuran-2-yl, naphth-1-yl, naphth-2-yl, quinolin-6-yl, 1-benzothien-2-yl, 1-benzothien-3-yl, 1-benzothien-5-yl, 1-benzothien-6-yl, 1-benzofuran-2-yl or 1-benzofuran-3-yl,

where biphenyl-4-yl, 1,3-benzodioxol-5-yl, 2,3-dihydro-1,4-benzodioxin-5-yl, 5-phenylthien-2-yl, 5-phenylfuran-2-yl, naphth-1-yl, naphth-2-yl, quinolin-6-yl, 1-benzothien-2-yl, 1-benzothien-3-yl, 1-benzothien-5-yl, 1-benzothien-6-yl, 1-benzofuran-2-yl and 1-benzofuran-3-yl may be substituted by 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of hydroxy, amino, halogen, cyano, trifluoromethyl, trifluoromethoxy, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino, hydroxycarbonyl, C 1 -C 6 -alkoxycarbonyl, aminocarbonyl, C 1 -C 6 -alkylaminocarbonyl, C 1 -C 6 -alkylcarbonyl and C 1 -C 6 -alkylcarbonylamino;

R 2 is hydrogen or C 1 -C 6 -alkyl;

R 3 is C 3 -C 7 -cycloalkyl or optionally up to pentafluoro-substituted C 1 -C 4 -alkyl; and

R 4 , R 5 and R 6 are independently of one another hydrogen, hydroxy, amino, halogen, cyano, trifluoromethyl, trifluoromethoxy, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino, C 3 -C 7 -cycloalkyl, 5- to 7-membered heterocyclyl, C 6 -C 10 -aryl, 5- or 6-membered heteroaryl, hydroxycarbonyl, C 1 -C 6 -alkoxycarbonyl, aminocarbonyl, C 1 -C 6 -alkyl-aminocarbonyl, C 1 -C 6 -alkylcarbonyl or C 1 -C 6 -alkylcarbonylamino,

in which cycloalkyl, heterocyclyl, aryl and heteroaryl may be substituted by 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of hydroxy, amino, halogen, cyano, trifluoromethyl, trifluoromethoxy, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino, hydroxycarbonyl, C 1 -C 6 -alkoxycarbonyl, aminocarbonyl, C 1 -C 6 -alkylaminocarbonyl, C 1 -C 6 -alkylcarbonyl and C 1 -C 6 -alkylcarbonylamino.

3. The compound as claimed in claim 1 , characterized in that

Y is a bond or methanediyl;

R 1 is biphenyl-4-yl, 1,3-benzodioxol-5-yl, 2,3-dihydro-1,4-benzodioxin-5-yl, 5-phenylthien-2-yl, 5-phenylfuran-2-yl, naphth-1-yl, naphth-2-yl, quinolin-6-yl, 1-benzothien-2-yl, 1-benzothien-3-yl, 1-benzothien-5-yl, 1-benzothien-6-yl, 1-benzofuran-2-yl or 1-benzofuran-3-yl,

where biphenyl-4-yl, 1,3-benzodioxol-5-yl, 2,3-dihydro-1,4-benzodioxin-5-yl, 5-phenylthien-2-yl, 5-phenylfuran-2-yl, naphth-1-yl, naphth-2-yl, quinolin-6-yl, 1-benzothien-2-yl, 1-benzothien-3-yl, 1-benzothien-5-yl, 1-benzothien-6-yl, 1-benzofuran-2-yl and 1-benzofuran-3-yl may be substituted by 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of hydroxy, amino, halogen, cyano, trifluoromethyl, trifluoromethoxy, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino, hydroxycarbonyl, C 1 -C 6 -alkoxycarbonyl, aminocarbonyl, C 1 -C 6 -alkylaminocarbonyl, C 1 -C 6 -alkylcarbonyl and C 1 -C 6 -alkylcarbonylamino;

R 2 is hydrogen or C 1 -C 6 -alkyl;

R 3 is C 3 -C 7 -cycloalkyl or optionally up to pentafluoro-substituted C 1 -C 4 -alkyl; and

R 4 , R 5 and R 6 are independently of one another hydrogen, halogen, cyano, trifluoromethyl, trifluoromethoxy, C 1 -C 6 -alkyl, C 3 -C 7 -cycloalkyl, hydroxycarbonyl, C 1 -C 6 -alkoxycarbonyl, aminocarbonyl, C 1 -C 6 -alkylaminocarbonyl, C 1 -C 6 -alkylcarbonyl or C 1 -C 6 -alkylcarbonylamino,

in which cycloalkyl may be substituted by 1 to 3 substituents, where the substituents are selected independently of one another from the group consisting of hydroxy, amino, halogen, cyano, trifluoromethyl, trifluoromethoxy, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylamino, hydroxycarbonyl, C 1 -C 6 -alkoxycarbonyl, aminocarbonyl, C 1 -C 6 -alkylaminocarbonyl, C 1 -C 6 -alkylcarbonyl and C 1 -C 6 -alkylcarbonylamino.

4. The compound as claimed in claim 1 , characterized in that

Y is a bond or methanediyl;

R 1 for biphenyl-4-yl, 5-phenylthien-2-yl, naphth-2-yl, quinolin-6-yl, 1-benzothien-2-yl or 1-benzofuran-2-yl,

where biphenyl-4-yl and naphth-2-yl may be substituted by 1 to 2 substituents, where the substituents are selected independently of one another from the group consisting of fluorine, chlorine, methoxy and ethoxy;

R 2 is hydrogen;

R 3 is methyl, ethyl or isopropyl; and

R 4 , R 5 and R 6 are independently of one another hydrogen or halogen.

5. A method for preparing a compound of the formula (Ia) as claimed in claim 1 , characterized in that

[A] a compound of the formula

in which

Y, R 2 , R 3 and R 7 have the meaning indicated in claim 1 ,

is reacted with a compound of the formula

in which

R 1 has the meaning indicated in claim 1 ,

or

[B] a compound of the formula

in which

R 1 and R 2 have the meaning indicated in claim 1 ,

is reacted with a compound of the formula

in which

Y, R 3 and R 7 have the meaning indicated in claim 1 , and

X 1 is halogen, preferably iodine or bromine, or hydroxy.

6. A pharmaceutical composition comprising a compound as claimed in any of claims 1 to 4 in combination with at least one inert, nontoxic, pharmaceutically suitable excipient.

7. A method for treating arteriosclerosis in humans and animals by administering an effective amount of at least one compound as claimed in any of claims 1 to 4 .