Triazolophthalazines

1. A compound of formula I

in which

R1 is —U-A, in which

U is a direct bond, or methylene (—CH 2 —),

A is phenyl, pyridinyl, thienyl, or R11- and/or R111-substituted phenyl, in which

R11 is 1-4C-alkyl, halogen, trifluoromethyl, hydroxyl, 1-4C-alkoxy, completely or predominantly fluorine-substituted 1-4C-alkoxy, phenoxy, 1-4C-alkoxycarbonyl, morpholino, or di-1-4C-alkylamino,

R111 is 1-4C-alkoxy, halogen, hydroxyl, or 1-4C-alkyl,

R2 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy, phenyl-1-4C-alkoxy, phenoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, halogen, trifluoromethyl, nitro, phenyl, R21-substituted phenyl, completely or predominantly fluorine-substituted 1-4C-alkoxy, 1-4C-alkylthio, cyano-1-4C-alkyl, or —N(R22)R23, in which

R21 is 1-4C-alkoxy, halogen or 1-4C-alkyl,

R22 and R23 together and with inclusion of the nitrogen atom, to which they are attached, form a heterocyclic ring Het1, in which

Het1 is optionally substituted by R24, and is a 3- to 7-membered monocyclic fully saturated heterocyclic ring radical comprising the nitrogen atom, to which R22 and R23 are bonded, and optionally one further heteroatom selected from the group consisting of nitrogen, oxygen and sulphur, in which

R24 is 1-4C-alkyl,

R3 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy or halogen,

or a salt thereof.

2. A compound of formula I according to claim 1 , in which

R1 is —U-A, in which

U is a direct bond, or methylene (—CH 2 —),

A is phenyl, pyridinyl, thienyl, dimethoxyphenyl, or R11-substituted phenyl, in which

R11 is methyl, tertbutyl, chlorine, fluorine, bromine, trifluoromethyl, hydroxyl, methoxy, ethoxy, trifluoromethoxy, phenoxy, methoxycarbonyl, morpholino, or dimethylamino,

R2 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy, phenyl-1-4C-alkoxy, phenoxy, halogen, phenyl, R21-substituted phenyl, completely or predominantly fluorine-substituted 1-4C-alkoxy, 1-4C-alkylthio, cyano-1-4C-alkyl, or —N(R22)R23, in which

R21 is 1-4C-alkoxy,

R22 and R23 together and with inclusion of the nitrogen atom, to which they are attached, form a heterocyclic ring Het1, in which

Het1 is pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, or 4N-(1-4C-alkyl)-piperazin-1-yl,

R3 is hydrogen or 1-4C-alkoxy,

or a salt thereof.

3. A compound of formula I according to claim 1 , in which

R1 is —U-A, in which

U is a direct bond, or methylene (—CH 2 —),

A is phenyl, 4-methoxy-phenyl, 2-methoxy-phenyl, 2-hydroxy-phenyl, 2-bromo-phenyl, 4-bromo-phenyl, 2-fluoro-phenyl, 2-(trifluoromethyl)-phenyl, 2-methyl-phenyl, 3-methoxy-phenyl, 3-bromo-phenyl, 3-fluoro-phenyl, 2-dimethylamino-phenyl, methoxycarbonyl, phenoxy, or 3-(trifluoromethyl)-phenyl,

R2 is hydrogen, 1-4C-alkyl, 1-4C-alkoxy, phenyl-1-4C-alkoxy, phenoxy, halogen, phenyl, R21-substituted phenyl, completely or predominantly fluorine-substituted 1-4C-alkoxy, 1-4C-alkylthio, cyano-1-4C-alkyl, or —N(R22)R23, in which

R21 is 1-4C-alkoxy,

R22 and R23 together and with inclusion of the nitrogen atom, to which they are attached, form a heterocyclic ring Het1, in which

Het1 is morpholin-4-yl, or 4N-(1-4C-alkyl)-piperazin-1-yl,

R3 is hydrogen or 1-4C-alkoxy,

or a salt thereof.

4. A compound of formula I according to claim 1 , in which

R1 is 4-methoxy-phenyl, 2-methoxy-phenyl, 3-methoxy-phenyl, 2-bromo-phenyl, 3-bromo-phenyl, 4-bromo-phenyl, 2-fluoro-phenyl, 3-fluoro-phenyl, 2-(trifluoromethyl)-phenyl, or 3-(trifluoromethyl)-phenyl;

R2 is hydrogen, methyl, methoxy, ethoxy, benzyloxy, chlorine, phenoxy, phenyl, 4-methoxy-phenyl, trifluoromethoxy, difluoromethoxy, methylthio, cyanomethyl, or —N(R22)R23, in which

R22 and R23 together and with inclusion of the nitrogen atom, to which they are attached, form a heterocyclic ring Het1, in which

Het1 is morpholin-4-yl, or 4N-methyl-piperazin-1-yl,

R3 is hydrogen, methoxy or ethoxy,

or a salt thereof.

5. A compound of formula I, selected from the group consisting of:

(4-Methoxyphenyl)-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

(3,4-Dimethoxy-phenyl)-[3-(4-methoxy-phenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

[3-(4-Methoxy-phenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-phenyl-amine,

(3-Benzyloxyphenyl)-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

(4-Chlorophenyl)-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

(4′-Methoxybiphenyl-4-yl)-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

(3-Methoxyphenyl)-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

[3-(4-Methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-(4-phenoxyphenyl)-amine,

[3-(4-Methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-(3-phenoxyphenyl)-amine,

(4-Benzyloxyphenyl)-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

[3-(4-Methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-p-tolyl-amine,

(4-Ethoxyphenyl)-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

[3-(4-Methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-(4-morpholin-4-yl-phenyl)-amine,

[3-(4-Methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-(4-trifluoromethoxyphenyl)-amine,

{4-[3-(4-Methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-ylamino]-phenyl}-acetonitrile,

[3-(4-Methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-(4-methylsulfanylphenyl)-amine,

(4-Morpholin-4-yl-phenyl)-[3-(4-phenoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

[3-(4-Methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-[4-(4-methylpiperazin-1-yl)-phenyl]-amine,

3-[6-(4-Morpholin-4-yl-phenylamino)-[1,2,4]triazolo[3,4-a]phthalazin-3-yl]-benzoic acid methyl ester,

(4-Morpholin-4-yl-phenyl)-[3-(4-morpholin-4-yl-phenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

[3-(4-Methoxy-benzyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-(4-morpholin-4-yl-phenyl)-amine,

4-[6-(4-Morpholin-4-yl-phenylamino)-[1,2,4]triazolo[3,4-a]phthalazin-3-yl]-benzoic acid methyl ester,

(3-Ethoxyphenyl)-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

[3-(4-Methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-(3-trifluoromethoxyphenyl)-amine,

(4-Morpholin-4-ylphenyl)-(3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)-amine,

2-[6-(4-Morpholin-4-yl-phenylamino)-[1,2,4]triazolo[3,4-a]phthalazin-3-yl]-phenol,

(3,5-Dimethoxyphenyl)-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

[3-(1,1-Difluoromethoxy)-phenyl]-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

(3,4-Diethoxyphenyl)-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

[4-(1,1-Difluoromethoxy)-phenyl]-[3-(4-methoxyphenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

(4-Bromo-phenyl)-[3-(4-methoxy-phenyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]-amine,

and the salts of these compounds.

6. A pharmaceutical composition comprising one or more compounds of formula I according to claim 1 or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable excipient and/or auxiliary.