IP Library Granted Patent US 8,186,869
Granted Patent B2
US 8,186,869 · App. 11/794,770 · Granted May 29, 2012

Method and device for dosing and mixing small amounts of liquid

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Quick Facts
Patent No.
US 8,186,869
App. No.
11/794,770
Granted
May 29, 2012
Kind
B2
Abstract

A method or device for integrated dosing and intermixing of small amounts of liquid, has a first liquid conveyed into or onto a first reservoir ( 3 ). A second reservoir ( 1 ) is entirely filled with a second liquid. The first and second liquids are brought into contact with each other via at least one joining duct structure ( 5 ) which has at least one area provided with a smaller cross section than the reservoirs ( 1,3 ) in the viewing direction of the connecting line between the two reservoirs ( 1,3 ). A laminar flow pattern is created along at least one portion of the joining duct structure ( 5 ), with the liquids thoroughly mixed in the second reservoir ( 1 ).

Claims (24)

1. A device for the integrated metering and mixing of small quantities of liquid comprising

a first reservoir for a first quantity of liquid;

a second reservoir for a second quantity of liquid;

filling passage structures which are in communication with a reservoir at one respective end and with a filling device at the other respective end;

at least two connection passage structures which connect the two reservoirs and have a cross-section at least in one region in the direction of view of the connection line of the reservoirs which is smaller than the cross-sections of the reservoirs;

at least one device for the generation of a laminar flow along at least one of said connection passage structures, the at least one device for the generation of laminar flow including a sound wave generation device having at least one radiation direction along at least a part of the at least one connection passage structure; and

at least one device for the mixing of the quantities of liquid, the device for the mixing of the quantities of liquid being located in or on the second reservoir.

2. A device in accordance with claim 1 , wherein the sound wave generation device is a surface sound wave generation device.

3. The device in accordance with claim 2 , wherein the surface sound wave generation device is an interdigital transducer.

4. A device in accordance with claim 1 , wherein the at least two connection passage structures have a narrow cross-section such that capillary forces are exerted onto at least one of the liquids by the side boundaries.

5. A device in accordance with claim 1 , wherein the reservoirs and the connection passage structures are formed by wells in a surface.

6. A device in accordance with claim 1 , wherein the reservoirs and the connection passage structures are formed by hollow spaces in a surface.

7. A device in accordance with claim 1 , wherein the reservoirs and the connection passage structures are defined by regions on a surface which are more preferably wetted by the liquids than the surrounding surface.

8. A device in accordance with claim 1 , having more than two reservoirs and a corresponding number of connection passage structures for the integrated metering and mixing of more than two quantities of liquid.

9. A device for the integrated metering and mixing of small quantities of liquid comprising,

a first reservoir for a first quantity of liquid;

a second reservoir for a second quantity of liquid;

filling passage structures which are in communication with a reservoir at one respective end and with a filling device at the other respective end;

at least two connection passage structures which connect the two reservoirs and have a cross-section at least in one region in the direction of view of the connection line of the reservoirs which is smaller than the cross-sections of the reservoirs;

at least one device for the generation of a laminar flow along at least one of said connection passage structures; and

at least one device for the mixing of the quantities of liquid, the device for the mixing of the quantities of liquid being located in or on the second reservoir, wherein the at least one device for the mixing includes a sound wave generation device for the generation of sound waves entering into the second reservoir.

10. A device in accordance with claim 9 ,

wherein the sound wave generation device is a surface sound wave generation device.

11. The device in accordance with claim 10 , wherein the surface sound wave generation device is an interdigital transducer.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 17, 2010
From: GAUER, CHRISTOPH
To: ADVALYTIX AG
Reel/Frame 023947/0213 →
MERGER Recorded Jan 26, 2010
From: ADVALYTIX AG
To: OLYMPUS LIFE SCIENCE RESEARCH EUROPA GMBH
Reel/Frame 023851/0477 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2010
From: OLYMPUS LIFE SCIENCE RESEARCH EUROPA GMBH
To: BECKMAN COULTER, INC.
Reel/Frame 023778/0153 →