Method for delivering interferon-β

1. A method for storing and delivering solutions of an Interferon-β comprising:

providing a device including a housing, wherein the housing comprises an aggregating metal;

removing or reducing an amount of the aggregating metal from the device; and

filling the solution of the Interferon-β into the housing, wherein, after filling the solution, the housing releases a concentration of the aggregating metal into the solution of less than 500 parts per billion.

2. The method of claim 1 , wherein the housing releases a concentration of the aggregating metal of less than 500 parts per billion after the solution is retained in the housing for greater than about 10 minutes.

3. The method of claim 2 , wherein the housing releases a concentration of the aggregating metal of less than about 500 parts per billion after the solution is retained in the housing for greater than about 120 minutes.

4. The method of claim 2 , wherein the housing releases a concentration of the aggregating metal of less than about 500 parts per billion after the solution is retained in the housing for greater than about 360 minutes.

5. The method of claim 2 , wherein the housing releases a concentration of the aggregating metal of less than about 500 parts per billion after the solution is retained in the housing for greater than about 480 minutes.

6. The method of claim 2 , wherein the housing releases a concentration of the aggregating metal of less than about 500 parts per billion after the solution is retained in the housing for about 120 minutes to about 480 minutes.

7. The method of claim 2 , wherein the housing releases a concentration of the aggregating metal of less than about 500 parts per billion after the solution is retained in the housing for about 300 minutes to about 420 minutes.

8. The method of claim 1 , wherein the housing releases a concentration of the aggregating metal of less than about 250 parts per billion.

9. The method of claim 1 , wherein the housing releases a concentration of the aggregating metal of less than about 100 parts per billion.

10. The method of claim 1 , wherein the housing releases a concentration of the aggregating metal of less than about 75 parts per billion.

11. The method of claim 1 , wherein the housing releases a concentration of the aggregating metal of less than about 50 parts per billion.

12. The method of claim 1 , wherein the aggregating metal is selected from the group consisting of iron, copper, nickel, molybdenum and tungsten.

13. The method of claim 12 , wherein the aggregating metal is tungsten.

14. The method of claim 1 , wherein the device is a syringe, bottle, vial or a bag.

15. The method of claim 14 , wherein the device is a syringe.

16. The method of claim 1 , wherein the housing of the device is constructed of glass, metal or plastic.

17. The method of claim 16 , wherein the housing is constructed of glass.

18. The method of claim 1 further comprising cleaning the device with an acid solution.

19. The method of claim 1 further comprising constructing the device to reduce the amount of aggregating metals to less than 500 parts per billion of tungsten.

20. A method for storing and delivering solutions of an Interferon-β comprising:

providing a device including a housing, wherein the housing comprises an aggregating metal;

removing or reducing an amount of the aggregating metal from the device; and

filling the solution of the Interferon-β into the housing, wherein, after filling the solution, the housing releases a total concentration of the aggregating metal into the solution of less than 500 parts per billion.

21. The method of claim 20 , wherein the housing releases a total concentration of the aggregating metal of less than about 500 parts per billion after the solution is retained in the housing for greater than about 10 minutes.

22. The method of claim 20 , wherein the housing releases a total concentration of the aggregating metal of less than about 500 parts per billion after the solution is retained in the housing for greater than about 120 minutes.

23. The method of claim 20 , wherein the housing releases a total concentration of the aggregating metal of less than about 500 parts per billion after the solution is retained in the housing for greater than about 360 minutes.

24. The method of claim 20 , wherein the housing releases a total concentration of the aggregating metal of less than about 500 parts per billion after the solution is retained in the housing for greater than about 480 minutes.

25. The method of claim 20 , wherein the housing releases a total concentration of the aggregating metal of less than about 500 parts per billion after the solution is retained in the housing for about 120 minutes to about 480 minutes.

26. The method of claim 20 , wherein the housing releases a total concentration of the aggregating metal of less than about 500 parts per billion after the solution is retained in the housing for about 300 minutes to about 420 minutes.

27. The method of claim 20 , wherein the housing releases a total concentration of the aggregating metal of less than about 250 parts per billion.

28. The method of claim 20 , wherein the housing releases a total concentration of the aggregating metal of less than about 100 parts per billion.

29. The method of claim 20 , wherein the housing releases a total concentration of the aggregating metal of less than about 75 parts per billion.

30. The method of claim 20 , wherein the housing releases a total concentration of the aggregating metal of less than about 50 parts per billion.

31. The method of claim 20 further comprising cleaning the device with an acid solution.

32. The method of claim 20 comprising constructing the device to reduce the amount of aggregating metals to less than 500 parts per billion of tungsten.

33. A method for storing and delivering solutions of an Interferon-β comprising:

providing a device including a housing, wherein the housing comprises an aggregating metal;

removing or reducing an amount of the aggregating metal from the device; and

filling the solution of the Interferon-β into the housing, wherein, after filling the solution, aggregation of the Interferon-β caused by the aggregating metal in the solution is less than 15% after storage.

34. The method of claim 33 , wherein aggregation of Interferon-β caused by the aggregating metal in the solution is less than 10% after storage.

35. The method of claim 34 , wherein aggregation of Interferon-β caused by the aggregating metal in the solution is less than 5% after storage.

36. The method of claim 33 , wherein aggregation of Interferon-β caused by the aggregating metal in the solution is less than 2% after storage.

37. The method of claim 1 , wherein the Interferon-β is an Interferon-β-1a.

38. The method of claim 33 further comprising cleaning the device with an acid solution.

39. The method of claim 33 comprising constructing the device to reduce the amount of aggregating metals to less than 500 parts per billion of tungsten.