IP Library › Patent Application 11805163
Patent Application
App. No. 11/805,163

Process for purifying N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-n-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process

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Patent No.
US None
App. No.
11/805,163
Abstract

Provided are novel Zaleplon crystalline Forms II, III, IV and V, which are useful for the treatment of insomnia.

Claims (6)

1 . A solid pharmaceutical composition comprising crystalline zaleplon Form III characterized by a powder X-ray diffraction pattern having peaks at 15.4, 18.1, 21.1, 26.8, and 27.5±0.2 degrees two-theta.

2 . A method of treating insomnia by administering the pharmaceutical composition of claim 1 .

3 . A solid pharmaceutical composition comprising crystalline zaleplon Form IV characterized by a powder X-ray diffraction pattern having peaks at 8.1, 14.5, 17.3, 21.3±0.2 degrees two-theta.

4 . A method of treating insomnia by administering the pharmaceutical composition of claim 3 .

5 . A solid pharmaceutical composition comprising crystalline zaleplon Form V characterized by a powder X-ray diffraction pattern having peaks at 8.0, 10.7, 11.0, 12.5, 14.8, 15.4, 16.5, 17.0, 17.7, 18.2, 21.3, 25.7, 26.5±0.2 degrees two-theta.

6 . A method of treating insomnia by administering the pharmaceutical composition of claim 5.