Use of a steroid prodrug for the treatment of disease of the posterior segment of the eye

1. A method of treating an ocular condition or disease of a human being or an animal, comprising

intravitreally administering to a posterior segment of an eye by an invasive means of intraocular injection a medicament or an ophthalmic composition, wherein,

said medicament or said ophthalmic composition comprises from 0.8% to about 5% w/w inactive dexamethasone palmitate,

said inactive dexamethasone palmitate is hydrolyzed by endogenous enzymes in the posterior segment of the eye to release active dexamethasone for treating said condition or said disease, and

said condition or said disease is of the back of the interior of the eye selected from the group consisting of: macular edema, macular degeneration, retinal detachment, ocular tumors, bacterial, fungal and viral infections, multifocal choroiditis, diabetic retinopathy, proliferative vitreoretinopathy (PVR), sympathetic opthalmia, Vogt Koyanagi-Harada (VKH) syndrome, histoplasmosis, uveal diffusion, and vascular occlusion.

2. The method according to claim 1 , wherein said medicament or said ophthalmic composition comprises about 0.8% to about 3% w/w of said dexamethasone palmitate.

3. The method according to claim 1 , wherein said dexamethasone palmitate is in combination with any ophthalmically acceptable excipient or carrier, or within an implant.

4. The method according to claim 3 , wherein said dexamethasone palmitate is in combination with a carrier selected from the group consisting of an ophthalmic acceptable oil, phospholipid vesicles, an oil-in-water emulsion and a water-in-oil emulsion.

5. The method to claim 4 , wherein the carrier is one of (i)an oil selected from the group consisting of MCT, castor oil and soybean oil, and (ii)an emulsion where the oil phase is selected from the group consisting of MCT, castor oil and soybean oil.

6. The method according to claim 4 , wherein,

the carrier is an emulsion,

and oil phase comprises at least about 1 weight percent of one of (i) said medicament or said ophthalmic composition and (ii) said emulsion.

7. The method according to claim 1 , wherein said dexamethasone palmitate is administered through one intraocular injection every one, two or six months.

8. The method according to claim 1 , wherein the amount of said medicament or said ophthalmic composition administered is such that, after one month, the molar ratio dexamethasone/dexamethasone palmitate in the retina or in the choroid is equal or less than 1.

9. The method according to claim 1 , wherein said medicament or said ophthalmic composition further comprises an active agent selected from the group consisting of cyclosporine, anti-VEGF, and an antibiotic.