Triazole compounds that modulate HSP90 activity

1. A compound represented by structural formula (IV):

or a tautomer or a pharmaceutically acceptable salt thereof, wherein:

X is a C1-C4 alkyl, NR 7 , C(O), C(S), C(NR 8 ), or S(O) p ;

R 1 is —SH or —OH;

R 3 and R 25 are —OH;

R 5 is an optionally substituted aryl, or an optionally substituted heteroaryl;

R 6 is a lower alkyl, C3-C6 cycloalkyl, lower alkoxy, a lower alkyl sulfanyl, or —NR 10 R 11 ;

R 7 and R 8 , for each occurrence, are, independently, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl;

R 10 and R 11 , for each occurrence, are independently —H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl; or R 10 and R 11 , taken together with the nitrogen to which the are attached, form an heterocyclyl or an heteroaryl;

p, for each occurrence, is, independently, 1 or 2;

provided that when X is —CH 2 —, —CH 2 CH 2 —, or —NH—, R 5 is not an unsubstituted phenyl, p-fluorophenyl, p-chlorophenyl, or trifluoromethyl-phenyl.

2. The compound of claim 1 , wherein R 5 is represented by the following structural formula:

wherein:

R 33 is H, a halo, lower alkyl, a lower alkoxy, a lower haloalkyl, a lower haloalkoxy, and lower alkyl sulfanyl;

R 34 is H, a lower alkyl, or a lower alkylcarbonyl; and

Ring B and Ring C are optionally substituted with one or more independently selected substituents, selected from the following group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteraralkyl, alkylaminoalkyl, dialkylaminoalkyl, alkylaminoalkoxy, dialkylaminoalkoxy, alkoxyalkylamino, alkoxydialkylamino, alkoxyalkylaminoalkoxy, alkoxydialkylaminoalkoxy, alkoxy, alkoxyalkyl, alkoxyalkoxy, cycloalkoxy, haloalkoxy, a haloalkyl, —C(O)NR 28 R 29 , —C(S)NR 28 R 29 , —C(NR 32 )NR 28 R 29 , —NR 30 C(O)R 31 , —NR 30 C(S)R 31 , —NR 30 C(NR 32 )R 31 , halo, —OR 30 , cyano, nitro, —C(O)R 30 , —C(S)R 30 , —C(NR 32 )R 30 , —NR 28 R 29 , —C(O)OR 30 , —C(S)OR 30 , —C(NR 32 )OR 30 , —OC(O)R 30 , —OC(S)R 30 , —OC(NR 32 )R 30 , —NR 30 C(O)NR 28 R 29 , —NR 30 C(S)NR 28 R 29 , —NR 30 C(NR 32 )NR 28 R 29 , —OC(O)NR 28 R 29 , —OC(S)NR 28 R 29 , —OC(NR 32 )NR 28 R 29 , —NR 30 C(O)OR 31 , —NR 30 C(S)OR 31 , —NR 30 C(NR 32 )OR 31 , —S(O) h R 30 , —OS(O) p R 30 , —NR 30 S(O) p R 30 , —S(O) p NR 28 R 29 , —OSS(O) p NR 28 R 29 , and —NR 30 S(O) p NR 28 R 29 ; wherein

R 28 and R 29 , for each occurrence are, independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl; or R 28 and R 29 taken together with the nitrogen to which they are attached is heterocyclyl or heteroaryl;

R 30 and R 31 for each occurrence are, independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl; and

R 32 , for each occurrence is, independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteraralkyl, —C(O)R 30 , —C(O)NR 28 R 29 , —S(O) p R 30 , or —S(O) p NR 28 R 29 ;

p, for each occurrence, is independently, 1 or 2; and

h is 0, 1 or 2.

3. The compound of claim 1 , wherein R 5 is represented by the following formula:

wherein:

X 8 , for each occurrence, is independently CH 2 , CHR 9 , C(R 9 ) 2 , O, S, S(O) p , NR 7 , or NR 17 ;

R 9 , for each occurrence, is independently a substituent selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteraralkyl, hydroxyalkyl, alkoxyalkyl, halo, cyano, nitro, guanadino, a haloalkyl, a heteroalkyl, —NR 10 R 11 , —OR 7 , —C(O)R 7 , —C(O)OR 7 , —OC(O)R 7 , —C(O)NR 10 R 11 , —NR 8 C(O)R 7 , —SR 7 , —S(O) p R 7 , —OS(O) p R 7 , —S(O) p OR 7 , —NR 8 S(O) p R 7 , or —S(O) p NR 10 R 11 , —S(O) p OR 7 , —OP(O)(OR 7 ) 2 , or —SP(O)(OR 7 ) 2 , —S(O) p OR 7 , —OP(O)(OR 7 ) 2 , or —SP(O)(OR 7 ) 2 ; or two R 9 groups taken together with the carbon atoms to which they are attached form a fused ring;

R 17 , for each occurrence, is independently —H, an alkyl, an aralkyl, —C(O)R 7 , —C(O)OR 7 , or —C(O)NR 10 R 11 ;

p, for each occurrence, is independently, 1 or 2; and

t is 0, 1 or 2.

4. The compound of claim 1 , wherein X is a C1-C4 alkyl.

5. The compound of claim 1 , wherein X is NR 7 , wherein R 7 is H or a C1-C4 alkyl.

6. The compound of claim 1 , wherein X is C(O).

7. The compound of claim 1 , wherein X is S(O) 2 .

8. A compound selected from the group consisting of:

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-methoxy-benzyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[(benzo[1,3]dioxol-5-yl)-methyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3,4-dichloro-benzyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3,4,5-trimethoxy-benzyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-methoxymethyl-benzyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3,5-dimethyl-benzyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[(2,3-dihydro-benzofuran-5-yl)-methyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[(1-methyl-1H-indol-5-yl)-methyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3-dimethylamino-4-methoxy-benzyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3,3-dimethoxy-benzyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[(6-chloro-pyridine-3-yl)-methyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[(6-methoxy-pyridine-3-yl)-methyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[(6-dimethylamino-pyridine-3-yl)-methyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(methoxymethyl-benzyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[3-(morpholin-4-ylmethyl)-benzyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-isopropoxy-benzyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[4-(1-methoxy-1-methyl-ethyl)-benzyl]-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-carboxy-benzyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-methanesulfonyl-benzyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[(2,3-dihydro-benzo[1,4]dioxin-6-yl)-methyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[2-(2-methoxy-ethyl-methyl-amino)-ethoxy-benzyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3,5-dimethoxy-benzyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3-methoxy-4-cyclopentyloxy-benzyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{4-[3-([1,2,3]triazol-1-yl)-propoxy]-benzyl}-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[4-(morpholin-4-yl-methyl)-benzyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{4-[3-(pyrrol-1-yl)-propoxy]-benzyl}-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{4-[2-(4-ethyl-piperazin-1-yl)-ethoxy]-benzyl}-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-benzyl}-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[3-(2-methoxy-ethoxy)-4-butoxy-benzyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[3-(morpholino-4-yl)-benzyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(2-trifluoromethyl-benzyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{3-methoxy-4-(2-methoxy-ethoxy)-benzyl}-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{4-[2-(morpholino-4-yl)-ethoxy]-benzyl}-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-fluoro-benzyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{3-[(4-methyl-piperazin-1-yl)-methyl]-benzyl}-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{4-[3-(morpholin-4-yl)-propoxy]-benzyl}-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[(benzo[1,3]dioxol-5-yl)-methyl]-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[3-(morpholin-4ylmethyl)-benzyl]-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{-4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-benzyl}-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[(6-dimethylamino-pyridine-3-yl)-methyl]-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3-methoxy-4-cyclopentyloxy-benzyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-methoxy-benzoyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-methoxy-benzoyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-methoxy-benzoyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(benzo[1,3]dioxol-5-carbonyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(benzo[1,3]dioxol-5-carbonyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[3-(morpholin-4ylmethyl)-benzoyl]-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[3-(morpholin-4ylmethyl)-benzoyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-benzoyl}-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-benzoyl}-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(6-dimethylamino-pyridine-3-carbonyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(6-dimethylamino-pyridine-3-carbonyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3-methoxy-4-cyclopentyloxy-benzoyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3-methoxy-4-cyclopentyloxy-benzoyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-methoxy-benzoyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-methoxy-benzoyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(benzo[1,3]dioxol-5-carbonyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(benzo[1,3]dioxol-5-carbonyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[3-(morpholin-4ylmethyl-benzoyl]-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[3-(morpholin-4ylmethyl-benzoyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-benzoyl}-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-benzoyl}-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(6-dimethylamino-pyridine-3-carbonyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(6-dimethylamino-pyridine-3-carbonyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3-methoxy-4-cyclopentyloxy-benzoyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3-methoxy-4-cyclopentyloxy-benzoyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-methoxy-phenylamino)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-methoxy-phenylamino)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(benzo[1,3]dioxol-5-ylamino)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(benzo[1,3]dioxol-5-ylamino)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[3-(morpholin-4-ylmethyl)-phenylamino]-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[3-(morpholin-4ylmethyl)-phenylamino]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenylamino}-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenylamino}-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(6-dimethylamino-pyridin-3-ylamino)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(6-dimethylamino-pyridin-3-ylamino)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3-methoxy-4-cyclopentyloxy-phenylamino)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3-methoxy-4-cyclopentyloxy-phenylamino)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-methoxy-benzenesulfonyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(4-methoxy-benzenesulfonyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(benzo[1,3]dioxol-5-sulfonyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(benzo[1,3]dioxol-5-sulfonyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[3-(morpholin-4ylmethyl)-benzenesulfonyl]-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-[3-(morpholin-4-ylmethyl)-benzensulfonyl]-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-benzenesulfonyl}-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-{-4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-benzenesulfonyl}-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(6-dimethylamino-pyridine-3-sulfonyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(6-dimethylamino-pyridine-3-sulfonyl)-5-mercapto-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3-methoxy-4-cyclopentyloxy-benzenesulfonyl)-5-hydroxy-4H-[1,2,4]triazole;

3-(2,4-hydroxy-5-isopropyl-phenyl)-4-(3-methoxy-4-cyclopentyloxy-benzenesulfonyl)-5-mercapto-4H-[1,2,4]triazole;

4-(4-(4-(1,3-dioxolan-2-yl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-(phenoxymethyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((dimethylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-(isopropoxymethyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-(cyclopentyloxymethyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-(pyrrolidin-1-ylmethyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((diethylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((dimethylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((isopropylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((methylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((ethylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((2-morpholinoethoxy)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((pyridin-2-ylmethoxy)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-(piperidin-1-ylmethyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((2-(pyridin-2-yl)ethoxy)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropyl benzene-1,3-diol;

4-(4-(3,4-dimethoxyphenethyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(3,5-dimethoxyphenethyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(2,3-dimethoxyphenethyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-(pyridin-3-yl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((4-methylpiperidin-1-yl)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-(6-aminopyridin-3-yl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((ethyl(methyl)amino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((butyl(methyl)amino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((isobutyl(methyl)amino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((cyclohexyl(methyl)amino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-(((2-methoxyethyl)(methyl)amino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((4-methylpiperazin-1-yl)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropyl benzene-1,3-diol;

4-(5-hydroxy-4-(4-(((2-methoxybenzyl)(methyl)amino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((benzyl(ethyl)amino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

diethyl 4-((3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)methyl)phenylphosphonate;

4-(5-hydroxy-4-(4-((isopropyl(methyl)amino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

3-((4-((3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)methyl)benzyl)-(methyl)amino)propanenitrile;

4-(5-hydroxy-4-(4-(thiomorpholinomethyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-((3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)methyl)benzyl)-piperazin-2-one;

4-(4-(4-((3-(dimethylamino)pyrrolidin-1-yl)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((octahydroisoquinolin-2(1H)-yl)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

(S)-4-(5-hydroxy-4-(4-((3-hydroxypyrrolidin-1-yl)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

(S)-methyl-1-(4-((3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)methyl)benzyl)pyrrolidine-2-carboxylate;

(S)-1-(4-((3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)methyl)-benzyl)pyrrolidine-2-carboxamide;

4-(5-hydroxy-4-(4-((4-(pyrrolidin-1-yl)piperidin-1-yl)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((methyl(prop-2-ynyl)amino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((methyl(propyl)amino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((bis(2-ethoxyethyl)amino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((bis(2-hydroxyethyl)amino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((2-methoxyethylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropyl benzene-1,3-diol;

4-(4-(4-((cyclohexylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-(((2-(dimethylamino)ethyl)(methyl)amino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

(R)-4-isopropyl-6-(5-mercapto-4-(1-(4-methoxyphenyl)ethyl)-4H-1,2,4-triazol-3-yl)benzene-1,3-diol;

(S)-4-isopropyl-6-(5-mercapto-4-(1-(4-methoxyphenyl)ethyl)-4H-1,2,4-triazol-3-yl)benzene-1,3-diol;

4-(5-hydroxy-4-(4-((3-methoxypropylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((prop-2-ynylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((2-hydroxyethylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((butylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((2-(dimethylamino)ethylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((isobutylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((3,5-dimethoxybenzylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((3-methoxybenzylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((4-fluorobenzylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((3,4-dimethoxyphenethylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((2-morpholinoethylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((cyclopentylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((2-(pyrrolidin-1-yl)ethylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((furan-2-ylmethylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((benzo[d][1,3]-dioxol-5-ylmethylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((cycloheptylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(furan-2-ylmethyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-fluorobenzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((4-methoxybenzylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((2-methoxybenzylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(2-(4-((3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)methyl)benzylamino)ethyl)benzenesulfonamide;

4-(5-hydroxy-4-(4-((pyridin-4-ylmethylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-(((tetrahydrofuran-2-yl)methylamino)triethyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((2-hydroxypropylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((4-methylbenzylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((3-fluorobenzylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-(((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((2-(piperidin-1-yl)ethylamino)methy)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-chlorobenzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(3-methoxybenzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((cyclopropylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-((4-chlorobenzylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((2-phenoxyethylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((2-(1-methylpyrrolidin-2-yl)ethylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(2-methoxybenzyl)-4H-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(3,4-dimethoxybenzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-methylbenzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-(hydroxymethyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-((3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)methyl)benzaldehyde;

(E)-4-(5-hydroxy-4-(4-((morpholinoimino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

(E)-4-(4-(4-((2,2-dimethylhydrazono)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-(4-(aminomethyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

1-(4-((3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)methyl)benzyl)guanidine;

2-(4-((3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)methyl)benzylamino)acetamide;

4-(4-(4-((3,4-dimethoxybenzylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

3-(4-((3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)methyl)benzylamino)propanenitrile;

4-(4-(4-((cyclopropylmethylamino)methyl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-((methyl(2-(pyridin-2-yl)ethyl)amino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

(4-((3-(2,4-dihydroxy-5-isopropylphenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)methyl)phenyl)-(morpholino)methanone;

N-cyclopentyl-4-((3-(2,4-dihydroxy-5-isopropylphenyl)-5-mercapto-4H-1,2,4-triazol-4-yl)methyl)benzamide;

4-(5-hydroxy-4-(4-((2-(pyridin-2-yl)ethylamino)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-(1-hydroxyethyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(5-hydroxy-4-(4-(hydroxy(phenyl)methyl)benzyl)-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

4-(4-benzyl-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

methyl-2-(4-((3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)methyl)benzylamino)acetate;

2-(4-((3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)methyl)-benzylamino)acetonitrile; and

4-(4-(4-(1H-pyrazol-4-yl)benzyl)-5-hydroxy-4H-1,2,4-triazol-3-yl)-6-isopropylbenzene-1,3-diol;

or pharmaceutically acceptable salts thereof.

9. A pharmaceutical composition, comprising a pharmaceutically acceptable carrier and a compound of claim 1 , or a tautomer, pharmaceutically acceptable salt thereof.

10. The pharmaceutical composition of claim 9 , further comprising one or more additional therapeutic agents.

11. The compound of claim 1 , wherein R 5 is a phenyl which is optionally substituted with from one to five substituents independently selected from the group consisting of alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteraralkyl, a haloalkyl, —C(O)NR 28 R 29 , —C(S)NR 28 R 29 , —C(NR 32 )NR 28 R 29 , —NR 30 C(O)R 31 , —NR 30 C(S)R 31 , —NR 30 C(NR 32 )R 31 , halo, —OR 30 , cyano, nitro, haloalkoxy, —C(O)R 30 , —C(S)R 30 , —C(NR 32 )R 30 , —NR 28 R 29 , —C(O)OR 30 , —C(S)OR 30 , —C(NR 32 )OR 30 , —OC(O)R 30 , —OC(S)R 30 , —OC(NR 32 )R 30 , —NR 30 C(O)NR 28 R 29 , —NR 30 C(S)NR 28 R 29 , —NR 30 C(NR 32 )NR 28 R 29 , —OC(O)NR 28 R 29 , —OC(S)NR 28 R 29 , —OC(NR 32 )NR 28 R 29 , —NR 30 C(O)OR 31 , —NR 30 C(S)OR 31 , —NR 30 C(NR 32 )OR 31 , —S(O) h R 30 , —OS(O) p R 30 , —NR 30 S(O) p R 30 , —S(O) p NR 28 R 29 , —OS(O) p NR 28 R 29 , or —NR 30 S(O) p NR 28 R 29 ;

R 28 and R 29 , for each occurrence are, independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl; or R 28 and R 29 taken together with the nitrogen to which they are attached is heterocyclyl or heteroaryl;

R 30 and R 31 for each occurrence are, independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl; and

R 32 , for each occurrence is, independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteraralkyl, —C(O)R 30 , —C(O)NR 28 R 29 , —S(O) p R 30 , or —S(O) p NR 28 R 29 ;

p, for each occurrence, is independently, 1 or 2; and

b is 0, 1 or 2.

12. The compound of claim 11 , wherein R 5 is a phenyl which is substituted with from one to five substituents independently selected from the group consisting of an alkyl, an alkoxy, an amino, an alkylamino, a dialkylamino, a cycloalkoxy, carboxy, —OC(O)R 26 , —C(O)OR 26 , —S(O) 2 R 26 , an alkoxyalkyl, a dialkylamino, an alkoxyalkoxy, an alkylaminoalkyl, a dialkylaminoalkyl, an alkylaminoalkoxy, a dialkylaminoalkoxy, an alkoxyalkylaminoalkoxy, an alkoxydialkylaminoalkoxy, heterocyclyl, an alkyl substituted with a heterocyclyl, an alkoxy substituted with a heterocyclyl, or a heteroaralkyl; wherein the heterocycle and the heteroaryl are optionally substituted with a lower alkyl; wherein R 26 , for each occurrence is, independently, a C1-C6 alkyl.

13. The compound of claim 11 , wherein R 5 is a phenyl which is substituted with one substituent selected from the group consisting of —(CH 2 ) 1-4 —NR 28 R 29 or —(CH 2 ) 1-4 —OR 30 .

14. The compound of claim 13 , wherein R 5 is a phenyl which is substituted with —CH 2 —NR 28 R 29 .

15. The compound of claim 14 , wherein X is —CH 2 —.

16. The compound of claim 1 , wherein R 5 is an optionally substituted aryl or an optionally substituted heteroaryl; wherein the aryl or heteroaryl is optionally substituted with alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteraralkyl, alkylaminoalkyl, dialkylaminoalkyl, alkylaminoalkoxy, dialkylaminoalkoxy, alkoxyalkylamino, alkoxydialkylamino, alkoxyalkylaminoalkoxy, alkoxydialkylaminoalkoxy, alkoxy, alkoxyalkyl, alkoxyalkoxy, cycloalkoxy, haloalkoxy, a haloalkyl, —C(O)NR 23 R 29 , —C(S)NR 28 R 29 , —C(NR 32 )NR 28 R 29 , —NR 30 C(O)R 31 , —NR 30 C(S)R 31 , —R 30 C(NR 32 )R 31 , halo, —OR 30 , cyano, nitro, —C(O)R 30 , —C(S)R 30 , —C(NR 32 )R 30 , —NR 28 R 29 , —C(O)OR 30 , —C(S)OR 30 , —C(NR 32 )OR 30 , —OC(O)R 30 , —OC(S)R 30 , —OC(NR 32 )R 30 , —NR 30 C(O)NR 28 R 29 , —NR 30 C(S)NR 28 R 29 , —NR 30 C(NR 32 )NR 28 R 29 , —OC(O)NR 28 R 29 , —OC(S)NR 28 R 29 , —OC(NR 32 )NR 28 R 29 , —NR 30 C(O)OR 31 , —NR 30 C(S)OR 31 , —NR 30 C(NR 32 )OR 31 , —S(O) h R 30 , —OS(O) p R 30 , —NR 30 S(O) p R 30 , —S(O) p NR 28 R 29 , —OSS(O) p NR 28 R 29 , or —NR 30 S(O) p —NR 28 R 29 ;

R 28 and R 29 , for each occurrence are, independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl; or R 28 and R 20 taken together with the nitrogen to which they are attached is heterocyclyl or heteroaryl;

R 30 and R 31 for each occurrence are, independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, or heteraralkyl; and

R 32 , for each occurrence is, independently, H, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteraralkyl, —C(O)R 30 , —C(O)NR 28 R 29 , —S(O) p R 30 , or —S(O) p NR 28 R 29 ;

p, for each occurrence, is independently, 1 or 2; and

h is 0, 1 or 2.