Separation device and chemical reaction apparatus made from polycrystalline diamond, apparatuses including same such as separation apparatuses, and methods of use
View Patent ↗The present invention relates to a porous polycrystalline diamond structure that may be employed as a separation device in a separation apparatus for separating at least one reaction product of a chemical reaction, as a stationary phase support and/or stationary phase in chromatography or separation apparatuses, or as a chemical reaction apparatus for conducting a chemical reaction therein. A separation device includes a body of sintered diamond particles. The body includes a proximal inlet end, a distal outlet end, and an intermediate region therebetween. The body further includes a plurality of at least partially interconnected pores that extend between the proximal inlet end and the distal outlet end. The at least partially interconnected pores are capable of communicating fluid from the proximal inlet end to the distal outlet end. Separation apparatuses that utilize the separation device, such as gas or liquid chromatography apparatuses, and chemical reaction apparatuses are also disclosed.
1. A separation device, comprising:
a sintered body comprised of a plurality of diamond-to-diamond bonded grains extending from a proximal inlet end to a distal outlet end and through an intermediate region between the proximal inlet end and distal the outlet end, the body further including a plurality of at least partially interconnected pores disposed among the plurality of diamond-to-diamond bonded grains, wherein the at least partially interconnected pores provide at least one fluid passage that extends through the sintered body from the proximal inlet end to the distal outlet end, wherein the pores associated with the at least one fluid passage exhibit a larger pore size at a location adjacent the proximal inlet end than they do at a location adjacent the distal outlet end.
2. The separation device of claim 1 , further comprising a substantially non-porous diamond coating formed on a peripheral surface of the intermediate region.
3. The separation device of claim 2 , wherein the substantially non-porous diamond coating comprises diamond deposited by chemical vapor deposition or physical vapor deposition.
4. The separation device of claim 1 wherein the plurality of diamond-to-diamond bonded grains comprise surfaces that are chemically modified.
5. The separation device of claim 1 wherein the plurality of diamond-to-diamond bonded grains exhibit an average size between about 1 nm to about 1000 μm.
6. The separation device of claim 1 wherein the at least partially interconnected pores exhibit a density that varies within the body.
7. The separation device of claim 1 wherein the body comprises another inlet for introducing at least one chemical reagent and a waste-product port spaced from the another inlet and the proximal inlet end.
8. The separation device of claim 7 , wherein the pores associated with the at least one passage exhibit a smaller size at locations between the waste-product port and the distal outlet end than they do between the proximal inlet end and the waste-product port.
9. The separation device of claim 1 , further comprising a stationary phase disposed within at least some of the plurality of pores including within at least a portion of the at least one fluid passage.
10. A separation apparatus, comprising:
a separation device including a sintered body comprised of a plurality of diamond-to-diamond bonded grains extending from a proximal inlet end to a distal outlet end and through an intermediate region between the proximal inlet end and the proximal outlet end, the body further including a plurality of at least partially interconnected pores disposed between the plurality of diamond-to-diamond bonded grains, wherein the at least partially interconnected pores provide at least one fluid passage that extends through the sintered body from the proximal inlet end to the distal outlet end, wherein the pores associated with the at least one fluid passage exhibit a larger pore size at a location adjacent the proximal inlet end than they do at a location adjacent the distal outlet end; and
a fluid supply system in fluid communication with the at least one fluid passage body of the separation device, the fluid supply system operable to pass fluid through the body.
11. The separation apparatus of claim 10 wherein the fluid supply system comprises:
a mobile phase supply configured to hold a mobile phase;
a pump operable to pump the mobile phase into the separation device; and
a sample supply configured to hold a sample to be analyzed, the sample supply fluidly coupled to the separation device.
12. The separation apparatus of claim 10 , further comprising:
a detector coupled to the separation device, the detector operable to identify at least one chemical constituent exiting through the outlet end of the body of the separation device.
13. The separation apparatus of claim 10 , wherein the body comprises another inlet for introducing at least one chemical reagent and a waste-product port spaced from the another inlet and the proximal inlet end.
14. The separation apparatus of claim 13 , wherein the pores associated with the at least one passage exhibit a smaller size at locations between the waste-product port and the distal outlet end than they do between the proximal inlet end and the waste-product port.