SUBSTITUTED BENZIMIDAZOLES FOR TREATMENT OF HISTOMONIASIS
The present invention relates to the use of substituted benzimidazoles for controlling histomoniasis, especially in turkeys.
1 .- 6 . (canceled)
7 . A method for controlling histomoniasis in poultry comprising, administering an effective amount of a benzimidazole of the formula (I) to the poultry in need thereof
in which
R 1 is fluoroalkyl,
R 2 is hydrogen or alkyl,
R 3 is a radical of the formula
or is a radical of the formula
R 4 is alkyl,
R 5 is alkyl or substituted phenyl,
R 6 is alkyl,
X 1 , X 2 , X 3 and X 4 are independently of one another hydrogen, halogen, haloalkyl, haloalkoxy, haloalkylthio or haloalkylsulphonyl,
or else
X 2 and X 3 or X 3 and X 4 together are a dioxyhaloalkylene radical.
8 . The method of claim 7 , wherein
R 1 is C 1 -C 4 -fluoroalkyl,
R 2 is hydrogen or C 1 -C 4 -alkyl,
R 4 is C 1 -C 4 -alkyl,
R 5 is C 1-6 -alkyl or phenyl which is optionally substituted one or more times by C 1-4 -alkyl, C 1-4 -haloalkyl, halogen, nitro, C 1-4 -alkoxy, C 1-4 -haloalkoxy or optionally mono- or poly-halogen-substituted methylene- or ethylenedioxy,
R 6 is C 1-4 -alkyl,
X 1 , X 2 , X 3 and X 4 are independently of one another hydrogen, F, Cl, Br, C 1 -C 4 -haloalkyl, C 1 -C 4 -haloalkoxy, C 1 -C 4 -haloalkylthio, C 1 -C 4 -haloalkylsulphonyl, or
X 2 and X 3 or X 3 and X 4 together are a dioxyhalo-C 1 -C 4 -alkylene radical.
9 . A method for controlling histomoniasis in poultry comprising, administering an effective amount of a benzimidazole of the formula (I-1)
to the poultry in need thereof.
10 . A method for controlling histomoniasis in poultry comprising, administering an effective amount of a benzimidazole of the formula (I-2)
to the poultry in need thereof.
11 . The method of claim 1 , wherein the poultry is a turkey.
12 . The method of claim 1 , wherein the effective amount is from 0.05 to 50 mg of the benzimidazole per kg of body weight of the poultry.