Process for producing amide compound and acrylamide polymer
View Patent ↗In a method for producing an amide compound of the present invention including obtaining an amide compound from a nitrile compound using a microbial catalyst and transferring a solution containing the microbial catalyst and the amide compound, a positive-displacement pump is used for transferring the solution containing a microbial catalyst and an amide compound to obtain an amide compound having few impurities. A monomer including (meth)acrylamide obtained by the method for producing an amide compound is polymerized to prepare an acrylamide polymer having a high-molecular mass and high solubility and being colorless.
1. A method for producing an amide compound, comprising:
reacting a nitrile compound with water in the presence of a microbial catalyst to obtain an amide compound, and
subsequently transferring a solution containing the microbial catalyst and the amide compound by a rotary pump to obtain the amide compound.
2. The method for producing an amide compound according to claim 1 , wherein the nitrile compound is (meth)acrylonitrile and the amide compound is (meth)acrylamide.
3. The method of claim 1 , wherein the reacting is conducted at a pH ranging from 5 to 9.5.
4. The method of claim 1 , wherein the reacting is conducted at a temperature ranging from 5.5° C. to 50° C.
5. The method of claim 1 , wherein the reacting is conducted until the amide constitutes from 30% to 60% by weight of the reaction solution.
6. The method of claim 1 , wherein the nitrile compound is continuously fed into the water in the presence of the microbial catalyst.
7. The method of claim 1 , wherein the rotary pump is employed only during the transferring step.
8. The method of claim 1 , wherein the microbial catalyst is a transformant expressing a nitrilhydratase.
9. The method of claim 8 , wherein the transformant is selected from the group consisting of Escheria coli MT10770 , Escheria coli MT10822, and Rhodococcus rhodochrous.
10. The method of claim 1 , wherein the nitrile compound is acrylonitrile and the amide compound is acrylamide.