IP Library Granted Patent US 9,700,652
Granted Patent B2
US 9,700,652 · App. 11/813,831 · Granted Jul 11, 2017

Absorbable medical implant made of fiber-reinforced magnesium or fiber-reinforced magnesium alloys

Inventors: Joerg Loeffler (Zürich, CH); Heinz Mueller (Erlangen, DE); Peter Uggowitzer (Ottenbach, CH); Gerhard Kappelt (Uttenreuth, DE)
Assignee: BIOTRONIK VI PATENT AG
A61L27/427A61L27/047
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Quick Facts
Patent No.
US 9,700,652
App. No.
11/813,831
Granted
Jul 11, 2017
Kind
B2
Abstract

A medical implant comprising a composite material which is composed of reinforcement fibers made of a magnesium-containing, bio-corrosive alloy, another bio-corrosive alloy containing a main component that is selected from the group consisting of Mg, Ca, Fe, and Y, or a non-biodegradable fiber material, embedded in a matrix made of crystalline magnesium or magnesium alloys.

Claims (29)

1. A medical implant, comprising: a biocorrodible alloy composite material comprising a matrix of crystalline magnesium or crystalline magnesium alloy which is reinforced using amorphous or nanocrystalline fibers made of a magnesium-containing, biocorrodible metal alloy, the amorphous or nanocrystalline fibers being embedded in the matrix of crystalline magnesium or crystalline magnesium alloy, wherein the implant is deformable, wherein the amorphous or nanocrystalline reinforcement fibers have a composition MgZnX, wherein (i) a proportion of Zn in the alloy is 10-40 weight-percent and (ii) X stands for one or more elements selected from the group consisting of Ln, Y, Si, AI, and Ca, and wherein a proportion of X in the alloy is 0-20 weight-percent.

2. The implant of claim 1 , wherein the amorphous or nanocrystalline reinforcement fibers have the composition MgZn, wherein a proportion of Zn in the alloy is from 26 to 32 weight-percent.

3. The implant of claim 2 , wherein the proportion of Zn in the alloy is 28.1 weight-percent.

4. The implant of claim 1 , wherein the amorphous or nanocrystalline reinforcement fibers have the composition MgZnLn, wherein a proportion of Ln in the alloy is from 1 to 12 weight-percent.

5. The implant of claim 1 , wherein the amorphous or nanocrystalline reinforcement fibers have the composition MgZnY, wherein a proportion of Y in the alloy is from 1 to 12 weight-percent.

6. The implant of claim 5 , wherein a proportion of Zn in the alloy is from 13 to 17 weight-percent and a proportion of Y in the alloy is from 8 to 12 weight-percent.

7. The implant of claim 6 , wherein a proportion of Zn in the alloy is approximately 15 weight-percent and a proportion of Y in the alloy is approximately 10 weight-percent.

8. The implant of claim 1 , wherein the amorphous or nanocrystalline reinforcement fibers have the composition MgZnSi, wherein a proportion of Si in the alloy is from 0.01 to 2 weight-percent.

9. The implant of claim 1 , wherein the amorphous or nanocrystalline reinforcement fibers have the composition MgZnAl, wherein a proportion of Al in the alloy is from 0.01 to 20 weight-percent.

10. The implant of claim 1 , wherein the amorphous or nanocrystalline reinforcement fibers have the composition MgZnCa, wherein a proportion of Ca in the alloy is from 0.01 to 20 weight-percent.

11. The implant of claim 1 , wherein the amorphous or nanocrystalline reinforcement fibers are woven as a woven fabric or mats.

12. The implant of claim 1 , wherein the amorphous or nanocrystalline reinforcement fibers have a diameter in the range of from 50 to 300 μm.

13. The implant of claim 1 , wherein the implant has an at least regionally porous surface.

14. The implant of claim 1 , wherein the implant comprises a vascular implant.

15. The implant of claim 14 , wherein the vascular implant comprises a stent and a main framework of the stent comprises fibers of the magnesium-containing biocorrodible metal alloy, wherein the fibers are woven as a woven fabric or mats.

16. The implant of claim 15 , wherein the stent is self-expanding.

17. The implant of claim 1 , wherein the implant is an orthopedic implant.

18. The implant of claim 1 , wherein the implant fixes tissue in the vascular system.

19. The implant of claim 1 , wherein the implant is an implant for use in pediatrics.

20. The implant of claim 1 , wherein the implant is an implant for treating vulnerable plaque.

21. The implant of claim 1 , wherein the amorphous or nanocrystalline fibers are supported over their entire area by the matrix of crystalline magnesium or crystalline magnesium alloy.

22. A medical implant, comprising: a biocorrodible alloy composite material comprising a matrix of crystalline magnesium or crystalline magnesium alloy which is reinforced using amorphous or nanocrystalline fibers made of a magnesium-containing, biocorrodible metal alloy, or another biocorrodible metal alloy, the amorphous or nanocrystalline fibers being embedded in the matrix of crystalline magnesium or crystalline magnesium alloy, a main component of the magnesium-containing, biocorrodible metal alloy, or the another biocorrodible metal alloy being selected from the group consisting of Mg, Ca, Fe, and Y, wherein the implant is deformable; and

wherein the amorphous or nanocrystalline reinforcement fibers have the composition:

MgY, wherein a proportion of Y in the alloy is from 1 to 30 weight-percent; or

MgYLn, wherein a proportion of Y in the alloy is from 1 to 30 weight-percent and a proportion of Ln in the alloy is from 1 to 12 weight-percent; or

MgCaAl, wherein a proportion of Ca in the alloy is from 0.01 to 20 weight-percent and a proportion of Al in the alloy is from 0.01 to 20 weight-percent; or

MgCaSi, wherein a proportion of Ca in the alloy is from 0.01 to 20 weight-percent and a proportion of Si in the alloy is from 0.01 to 2 weight-percent.

23. The implant of claim 22 , wherein the amorphous or nanocrystalline reinforcement fibers have the composition MgY, and wherein a proportion of Y in the alloy is from 7 to 11 weight-percent.

24. The implant of claim 22 , wherein the amorphous or nanocrystalline reinforcement fibers have the composition MgY, and wherein the proportion of Y in the alloy is 8.9 weight-percent.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 25, 2018
From: BIOTRONIK VI PATENT AG
To: BIOTRONIK AG
Reel/Frame 047166/0462 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 13, 2007
From: LOEFFLER, JOERG; MUELLER, HEINZ; UGGOWITZER, PETER; KAPPELT, GERHARD
To: BIOTRONIK VI PATENT AG
Reel/Frame 019552/0965 →
Priority Claims (1)
DE 10 2005 003 188 · Jan 20, 2005 · national
Continuity (1)
Related Publication 20080103594A1 · May 1, 2008