TABLET COMPRISING ORNITHINE HYDROCHLORIDE
The present invention has an object to provide a tablet capable of comprising ornithine hydrochloride in a higher content; and a process for producing the same, and provides the tablet comprising ornithine hydrochloride and maltose, or a linear or cyclic dextrin; and the process for producing a tablet comprising ornithine hydrochloride, which comprises compression molding a mixture comprising ornithine hydrochloride and maltose, or a linear or cyclic dextrin by a direct tableting method.
1 . A tablet comprising (i) ornithine hydrochloride and (ii) maltose, or a linear or cyclic dextrin.
2 . The tablet according to claim 1 , wherein the content of ornithine hydrochloride is 50% or more by mass in the tablet.
3 . The tablet according to claim 1 or 2 , wherein the content of the maltose, or the linear or cyclic dextrin is from 5 to 20% by mass in the tablet.
4 . The tablet according to claim 3 , comprising β-cyclodextrin.
5 . The tablet according to claim 3 , further comprising cellulose or a cellulose derivative.
6 . The tablet according to claim 5 , wherein the cellulose or the cellulose derivative is microcrystalline cellulose with a particle size of from 20 to 60 μm.
7 . The tablet according to claim 3 , wherein the tablet hardness is from 30 to 150 N.
8 . A process for producing a tablet comprising ornithine hydrochloride, which comprises compression molding a mixture comprising (i) ornithine hydrochloride and (ii) maltose, or a linear or cyclic dextrin by a direct tableting method.
9 . A process for producing a tablet comprising ornithine hydrochloride, which comprising the steps of: granulating a mixture comprising (i) ornithine hydrochloride and (ii) maltose, or a linear or cyclic dextrin; and performing compression molding the granulated mixture.
10 . The tablet according to claim 4 , further comprising cellulose or a cellulose derivative.
11 . The tablet according to claim 10 , wherein the cellulose or the cellulose derivative is microcrystalline cellulose with a particle size of from 20 to 60 μm.
12 . The tablet according to claim 5 , wherein the tablet hardness is from 30 to 150 N.
13 . The tablet according to claim 6 , wherein the tablet hardness is from 30 to 150 N.