Non steroidal glucocorticoid receptor modulators

1. A compound according to formula I:

or a pharmaceutically acceptable salt thereof, wherein

R 1 is H or (1-4C)alkyl;

R 2 is —C(O)R 15 or —S(O) 2 R 15 ;

R 3 is H, (1-4C)alkyl or —OR 16 ;

R 4 is H, (1-4C)alkyl or —OR 16 ;

R 6 is H, —C(H)NOR 16 ;

R 7 is H, halogen or cyano;

or R 7 is (1-6C)alkyl, (2-6C)alkenyl or (2-6C)alkynyl, all three optionally substituted with OH, halogen or NH 2 ;

or R 7 is —C(H)NOR 16 , —OR 16 , —C(O)OR 16 or —C(O)R 16 ;

R 8 is cyano;

or R 8 is (1-6C) alkyl, (2-6C)alkenyl, (2-6C)alkynyl or —O(1-6C)alkyl, all substituted with amino, hydroxyl or halogen;

or R 8 is (hetero)aryl, optionally substituted with cyano, halogen, (1-4C)alkyl, (1-4C)alkoxy or (1-4C)alkoxy(1-4C)alkyl;

or R 8 is —C(H)NOR 16 , —C(O)NHR 17 , —C(O)R 18 , —C(O)OR 19 , or —C(1-4C)alkylNOR 21 ;

R 9 is H, halogen, cyano or (1-4C)alkyl optionally substituted with halogen

R 10 is H or (1-4C)alkyl;

R 11 is H;

R 12 is H, cyano or (1-4C)alkyl;

R 13 is H, (1-4C)alkyl, halogen or formyl;

R 14 is H, halogen, cyano, (1-4C)alkyl, (2-6C)alkenyl, C(O)R 21 or (hetero)aryl;

R 15 is H;

or R 15 is (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl, —O(2-6C)alkyl, —O(2-6C)alkenyl or —O(2-6C)alkynyl, all optionally substituted with one or more OH, halogen, cyano or (hetero)aryl;

or R 15 is (hetero)aryl, optionally substituted with (1-4C)alkyl, halogen, cyano, nitro or amino;

or R 15 is NH 2 , (di)(1-4C)alkylamino, (1-4C)alkyl(1-4C)alkoxyamine, (1-4C)alkylthio(1-4C)alkyl or (1-4C)alkoxy(1-4C)alkyl;

each R 16 independently is H, (1-6C)alkyl, (2-6C)alkenyl or (2-6C)alkynyl;

R 17 is H, (1-4C)alkoxy or (3-6C)cycloalkyl;

or R 17 is (1-6C)alkyl, optionally substituted with halogen;

or R 17 is (hetero)aryl, optionally substituted with halogen, (1-4C)alkyl or (1-4C)alkoxy;

R 18 is H, NH 2 , —C(O)R 21 or —S(1-4C)alkyl;

or R 18 is (1-4C)alkyl, optionally substituted with OH, halogen or cyano;

R 19 is H or (1-6C)alkyl, optionally substituted with OH or halogen, and

each R 21 independently is H or (1-6C)alkyl.

2. The compound according to claim 1 wherein R 7 is H or halogen or OR 16 .

3. The compound according to claim 1 wherein R 7 is H.

4. The compound according to claim 1 wherein R 10 is methyl.

5. The compound according to claim 1 wherein each R 16 is independently H or (1-6C)alkyl.

6. The compounds according to claim 1 wherein R 2 is C(O)R 15 .

7. The compound according to claim 1 wherein R 15 is (1-4C)alkyl, optionally substituted with halogen.

8. The compound according to claim 7 wherein R 15 is trifluoromethyl.

9. The compound according to claim 1 wherein each R 21 is independently (1-4C)alkyl.

10. The compound according to claim 1 wherein R 8 is cyano or C(O)R 18 ;

or R 8 is (hetero)aryl, optionally substituted with cyano, (1-4C)alkyl, (1-4C)alkoxy, or (1-4C)alkoxy(1-4C)alkyl.

11. The compound according to claim 1 wherein R 8 is cyano or pyridyl.