Method and apparatus for assessing vascular conditions
A method suitable for assessing the vascular condition of a subject is disclosed. The method comprises: measuring the transit time TT 1 of a blood wavefront from the subject's heart to a distal point in a limb of the subject, and measuring the transit time TT 2 of a blood wavefront from an intermediate point in the limb of the subject to the distal point of the subject's limb. The method further comprises computing the ratio TT 2 /TT 1 and determining the likelihood that a small vessel disease condition exists when the ratio TT 2 /TT 1 is above a preselected threshold.
1 . A method of assessing the vascular condition of a subject, comprising measuring transit times of a blood wavefront along at least two segments in the body of the subject, using said transit times for calculating a predefined vascular condition index, and assessing the vascular condition based on a value of said vascular condition index.
2 . The method of claim 1 , wherein at least one segment is defined between the heart of the subject and a location in a limb of the subject.
3 . The method of claim 1 , wherein at least one segment is defined between two locations in a limb of the subject.
4 . The method of claim 2 , wherein said at least two segments comprise a first segment defined between the heart and a distal point in said limb, and a second segment defined between an intermediate point in said limb and said distal point.
5 . The method of claim 1 , wherein said assessing the vascular condition comprises determining the likelihood that a small vessel disease condition exists.
6 . The method of claim 4 , wherein said vascular condition index comprises the ratio TT 2 /TT 1 , said TT 1 being a first transit time from the heart to said distal point and said TT 2 is a second transit time of blood wavefront from said intermediate point to said distal point.
7 . The method of claim 6 , wherein said assessing the vascular condition comprises if said ratio is above a preselected threshold then determining the likelihood that a small vessel disease condition exists.
8 . The method of claim 4 , wherein said distal point in the subject's limb is a toe of a foot of the subject; and said intermediate point in the subject's limb is a point in the ankle region of said foot of the subject.
9 . The method of claim 7 , wherein said preselected threshold is equivalent to about 20 percents.
10 . The method of claim 4 , wherein said transit times are measured by using a predetermined reference point in the output signals of blood wavefront sensors at the respective intermediate and distal points of the subject's limb as a time marker for marking the arrival times of the blood wavefront at said intermediate point and distal point, respectively, in said limb of the subject.
11 . The method of claim 6 , wherein said TT 1 is measured by utilizing a predetermined reference point in the subject's ECG signal as a time marker for marking the starting time of the blood wavefront from the subject's heart.
12 . The method of claim 6 , wherein said TT 1 and TT 2 are measured by utilizing a predetermined reference point in the output signal of a blood wavefront sensor located at the heart region of the subject as a time marker for marking the starting time of the blood wavefront from the subject's heart.
13 . Apparatus for assessing the vascular condition of a subject, comprising:
sensors adapted for measuring transit times of a blood wavefront along at least two segments in the body of the subject;
a data processor for calculating a predefined vascular condition index using said transit times; and
a display device for displaying a value of said vascular condition index to thereby provide an indication of the vascular condition.
14 . The apparatus of claim 13 , wherein at least one of said sensors is adapted for sensing the arrival time of the blood wavefront at a location in limb of the subject.
15 . The apparatus of claim 13 , wherein said data processor is configured for signaling said display device to provide an indication of the likelihood that a small vessel disease condition exists.
16 . The apparatus of claim 14 , wherein said at least two segments comprise a first segment defined between the heart and a distal point in said limb, and a second segment defined between an intermediate point in said limb and said distal point.
17 . The apparatus of claim 16 , wherein said vascular condition index comprises the ratio TT 2 /TT 1 , said TT 1 being a first transit time from the heart to said distal point and said TT 2 is a second transit time of blood wavefront from said intermediate point to said distal point.
18 . The apparatus of claim 17 , wherein said data processor is configured to compare said ratio with a preselected threshold, and to signal said display device to provide an indication of the likelihood that a small vessel disease condition exists if said ratio is above said preselected threshold.
19 . The apparatus of claim 18 , wherein said preselected threshold is equivalent to about 20 percents.
20 . The apparatus of claim 12 , wherein said sensors comprise a toe sensor for sensing the arrival time of the blood wavefront at the subject's toe for determining said TT 1 , and an ankle sensor for sensing the arrival time of the blood wavefront at the subject's ankle for determining said TT 2 .
21 . The apparatus of claim 12 , wherein said sensors comprise ECG signal sensors for sensing the ECG signal of the subject, wherein said signal is used by said data processor as a time marker for marking the starting time of the blood wavefront from the subject's heart for determining said TT 1 .
22 . The apparatus of claim 12 , wherein said sensors comprise a movement sensor for directly sensing movement in the region of the subject's heart and for producing an output signal corresponding to such movement, said output signal being used by said data processor as a time marker for marking the starting time of the blood wavefront from the subject's heart for determining said TT 1 .
23 . A method of characterizing vascular of a subject, comprising calculating a predefined vascular condition index based on transit times of a blood wavefront along at least two segments in the body of the subject thereby characterizing the vascular condition.
24 . The method of claim 23 , wherein at least one segment is defined between the heart of the subject and a location in a limb of the subject.
25 . The method of claim 23 , wherein at least one segment is defined between two locations in a limb of the subject.
26 . The method of claim 24 , wherein said at least two segments comprise a first segment defined between the heart and a distal point in said limb, and a second segment defined between an intermediate point in said limb and said distal point.
27 . The method of claim 26 , wherein said vascular condition index comprises the ratio TT 2 /TT 1 , said TT 1 being a first transit time from the heart to said distal point and said TT 2 is a second transit time of blood wavefront from said intermediate point to said distal point.
28 . The method of claim 27 , wherein said characterization comprises the likelihood that a small vessel disease condition exists.
29 . The method of claim 26 , wherein said distal point in the subject's limb is a toe of a foot of the subject; and said intermediate point in the subject's limb is a point in the ankle region of said foot of the subject.