Human protein tyrosine phosphatase inhibitors and methods of use
View Patent ↗The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta (HPTP-β) inhibitors thereby regulating angiogenesis. The present disclosure further relates to compositions comprising said human protein tyrosine phosphatase beta (HPTP-β) inhibitors, and to methods for regulating angiogenesis.
1. A compound of the formula:
wherein R is a substituted or unsubstituted thiazolyl unit having the formula:
R 4 and R 5 are each independently chosen from:
i) hydrogen;
ii) substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl;
iii) substituted or unsubstituted phenyl; and
iv) substituted or unsubstituted heteroaryl; or
R 4 and R 5 can be taken together to form a saturated or unsaturated ring having from 5 to 7 atoms;
said substitutions are independently chosen from one or more C 1 -C 6 linear- or branched alkyl, or C 3 -C 6 cyclic alkyl, halogen, hydroxy, OCH 3 , CF 3 , N(R 12 ) 2 or cyano units;
R 12 is independently hydrogen or C 1 -C 4 linear or branched alkyl;
R 6 is a unit chosen from:
i) hydrogen;
ii) substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl;
iii) substituted or unsubstituted phenyl; and
iv) substituted or unsubstituted heteroaryl;
R 1 is chosen from:
i) hydrogen;
ii) C 1 -C 6 linear or branched alkyl;
iii) substituted or unsubstituted phenyl; or
iv) substituted or unsubstituted benzyl;
R 2 is chosen from:
i) C 1 -C 6 linear or branched alkyl; or
ii) C 1 -C 6 linear or branched alkoxy;
R 3 is hydrogen or C 1 -C 4 linear or branched alkyl;
or a pharmaceutically acceptable salt thereof.
2. A compound according to claim 1 , wherein R has the formula:
3. A compound according to claim 2 , wherein R 4 and R 5 are each hydrogen.
4. A compound according to claim 2 , wherein R 5 is hydrogen and R 4 is substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl.
5. A compound according to claim 4 , wherein R 4 is chosen from methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, n-pentyl, 1-methylbutyl, 2-methylbutyl, 3-methylbutyl, cyclopropyl, n-hexyl, and cyclohexyl.
6. A compound according to claim 4 , wherein R 4 is chosen from units having the formulae —CH 2 F, —CHF 2 , —CF 3 , —CH 2 CF 3 , —CH 2 CH 2 CF 3 , —CH 2 Cl, —CH 2 OH, —CH 2 OCH 3 , —CH 2 CH 2 OH, —CH 2 CH 2 OCH 3 , —CH 2 NH 2 , —CH 2 NHCH 3 , —CH 2 N(CH 3 ) 2 , and —CH 2 NH(CH 2 CH 3 ).
7. A compound according to claim 4 , wherein R 4 is 2,2-difluorocyclopropyl, 2-methoxycyclohexyl, or 4-chlorocyclohexyl.
8. A compound according to claim 2 , wherein R 5 is hydrogen and R 4 is substituted or unsubstituted phenyl.
9. A compound according to claim 8 , wherein R 4 is chosen from phenyl, 3,4-dimethylphenyl, 4-tert-butylphenyl, 4-cyclopropylphenyl, 4-diethylaminophenyl, 4-(trifluoromethyl)phenyl, 4-methoxyphenyl, 3-chlorophenyl, 4-chlorophenyl, and 3,4-dichlorophenyl.
10. A compound according to claim 2 , wherein R 5 is hydrogen and R 4 is substituted or unsubstituted heteroaryl.
11. A compound according to claim 10 , wherein R 4 is a substituted or unsubstituted heteroaryl unit, said heteroaryl unit chosen from 1,2,3,4-tetrazol-1-yl, 1,2,3,4-tetrazol-5-yl, [1,2,3]triazol-4-yl, [1,2,3]triazol-5-yl, [1,2,4]triazol-4-yl, [1,2,4]triazol-5-yl, imidazol-2-yl, imidazol-4-yl, pyrrol-2-yl, pyrrol-3-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, [1,2,4]oxadiazol-3-yl, [1,2,4]oxadiazol-5-yl, [1,3,4]oxadiazol-2-yl, furan-2-yl, furan-3-yl, thiophene-2-yl, thiophene-3-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, [1,2,4]thiadiazol-3-yl, [1,2,4]thiadiazol-5-yl, and [1,3,4]thiadiazol-2-yl.
12. A compound according to claim 11 , wherein R 4 is chosen from furan-2-yl, thiophene-2-yl, 5-chlorothiophene-2-yl, and 5-methylthiophene-2-yl.
13. A compound according to claim 1 , wherein R is a unit wherein R 4 and R 5 are taken together to form a saturated or unsaturated ring having from 5 to 7 atoms.
14. A compound according to claim 13 , wherein R is 5,6-dihydro-4H-cyclopenta[d]thiazol-2-yl or 4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl.
15. A compound according to claim 1 , wherein R units have the formula
16. A compound according to claim 15 , wherein R 6 is hydrogen.
17. A compound according to claim 15 , wherein R 6 is chosen from methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, and tert-butyl.
18. A compound according to claim 15 , wherein R 6 is substituted or unsubstituted phenyl.
19. A compound according to claim 18 , wherein R 6 is chosen from include phenyl, 2-fluorophenyl, 2-chlorophenyl, 2-methylphenyl, 2-methoxyphenyl, 3-fluorophenyl, 3-chlorophenyl, 3-methylphenyl, 3-methoxyphenyl, 4-fluorophenyl, 4-chlorophenyl, 4-methylphenyl, and 4-methoxyphenyl.
20. A compound according to claim 15 , wherein R 6 is a substituted or unsubstituted heteroaryl unit, said heteroaryl unit chosen from 1,2,3,4-tetrazol-1-yl, 1,2,3,4-tetrazol-5-yl, [1,2,3]triazol-4-yl, [1,2,3]triazol-5-yl, [1,2,4]triazol-4-yl, [1,2,4]triazol-5-yl, imidazol-2-yl, imidazol-4-yl, pyrrol-2-yl, pyrrol-3-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, [1,2,4]oxadiazol-3-yl, [1,2,4]oxadiazol-5-yl, [1,3,4]oxadiazol-2-yl, furan-2-yl, furan-3-yl, thiophene-2-yl, thiophene-3-yl, isothiazol-3-yl, isothiazol-4-yl, isothiazol-5-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, [1,2,4]thiadiazol-3-yl, [1,2,4]thiadiazol-5-yl, and [1,3,4]thiadiazol-2-yl.
21. A compound according to claim 20 , wherein R 6 is chosen from thiophene-2-yl, thiophene-3-yl, thiazol-2-yl, thiazol-4-yl, thiazol-5-yl, 2,5-dimethylthiazol-4-yl, 2,4-dimethylthiazol-5-yl, 4-ethylthiazol-2-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, and 3-methyl-1,2,4-oxadiazol-5-yl.
22. A compound according to claim 15 , wherein R 6 has the formula:
R 7 is C 1 -C 4 substituted or unsubstituted alkyl or substituted or unsubstituted phenyl.
23. A compound according to claim 22 , wherein R 6 is 4-chlorobenzenesulfonylmethyl or tert-butylsulfonylmethyl.
24. A compound according to claim 1 , wherein R 1 is hydrogen.
25. A compound according to claim 1 , wherein R 1 is substituted or unsubstituted phenyl or benzyl.
26. A compound according to claim 25 , wherein R 1 is benzyl.
27. A compound according to claim 1 , wherein R 1 is C 1 -C 6 linear or branched alkyl.
28. A compound according to claim 27 , wherein R 1 is iso-propyl.
29. A compound according to claim 1 , wherein R 2 is a C 1 -C 6 linear or branched alkoxy unit having the formula:
—OR 8
wherein R 8 is a C 1 -C 6 linear or branched alkyl unit chosen from methyl, ethyl, n-propyl, iso-propyl, n-butyl, sec-butyl, iso-butyl, tert-butyl, n-pentyl, or n-hexyl.
30. A compound according to claim 29 , wherein R 8 is methyl, ethyl, or tert-butyl.
31. A compound according to claim 1 , wherein R 2 is a C 1 -C 6 linear or branched alkyl unit.
32. A compound according to claim 1 , wherein R 3 is hydrogen or methyl.
33. A compound according to claim 32 , wherein R 3 is hydrogen.
34. A compound of the formula:
wherein R 2 is chosen from:
i) C 1 -C 6 linear or branched alkyl; or
ii) C 1 -C 6 linear or branched alkoxy;
R 4 and R 5 are each independently chosen from:
i) hydrogen;
ii) substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl;
iii) substituted or unsubstituted phenyl; and
iv) substituted or unsubstituted heteroaryl; or
R 4 and R 5 can be taken together to form a saturated or unsaturated ring having from 5 to 7 atoms.
35. A compound of the formula:
wherein R 2 is chosen from:
i) C 1 -C 6 linear or branched alkyl; or
ii) C 1 -C 6 linear or branched alkoxy;
R 6 is chosen from:
i) hydrogen;
ii) substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl;
iii) substituted or unsubstituted phenyl; and
iv) substituted or unsubstituted heteroaryl.
36. A compound of the formula:
wherein R 2 is chosen from:
i) C 1 -C 6 linear or branched alkyl; or
ii) C 1 -C 6 linear or branched alkoxy;
R 4 and R 5 are each independently chosen from:
i) hydrogen;
ii) substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl;
iii) substituted or unsubstituted phenyl; and
iv) substituted or unsubstituted heteroaryl; or
R 4 and R 5 can be taken together to form a saturated or unsaturated ring having from 5 to 7 atoms.
37. A compound of the formula:
wherein R 2 is chosen from:
i) C 1 -C 6 linear or branched alkyl; or
ii) C 1 -C 6 linear or branched alkoxy;
R 6 is chosen from:
i) hydrogen;
ii) substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl;
iii) substituted or unsubstituted phenyl; and
iv) substituted or unsubstituted heteroaryl.
38. A compound of the formula:
wherein R 2 is chosen from:
i) C 1 -C 6 linear or branched alkyl; or
ii) C 1 -C 6 linear or branched alkoxy;
R 4 and R 5 are each independently chosen from:
i) hydrogen;
ii) substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl;
iii) substituted or unsubstituted phenyl; and
iv) substituted or unsubstituted heteroaryl; or
R 4 and R 5 can be taken together to form a saturated or unsaturated ring having from 5 to 7 atoms.
39. A compound of the formula:
wherein R 2 is chosen from:
i) C 1 -C 6 linear or branched alkyl; or
ii) C 1 -C 6 linear or branched alkoxy;
R 6 is chosen from:
i) hydrogen;
ii) substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl;
iii) substituted or unsubstituted phenyl; and
iv) substituted or unsubstituted heteroaryl;
or a pharmaceutically acceptable salt thereof.
40. A compound chosen from;
4-{(S)-2-[(S)-2-(tert-Butoxycarbonylamino)-3-phenylpropanamido]-2-(4-ethylthiazol-2-yl)ethyl}phenylsulfamic acid;
4-{(S)-2-[(R)-2-(tert-Butoxycarbonylamino)-3-phenylpropanamido]-2-(4-ethylthiazol-2-yl)ethyl}phenylsulfamic acid;
{1-[1-(5-Ethylthiazol-2-yl)-(S)-2-(4-sulfoaminophenyl)ethylcarbamoyl]-(S)-2-phenylethyl}methyl carbamic acid tert-butyl ester;
{(S)-2-Phenyl-1-[1-(2-phenylthiazol-2-yl)-(S)-2-(4-sulfoaminophenyl)ethyl-carbamoyl]ethyl}carbamic acid tert-butyl ester
4-{(S)-2-(4-Ethylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-(thiazol-2-yl)ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-(4-methylthiazol-2-yl)ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-(4-propylthiazol-2-yl)ethyl}phenylsulfamic acid;
4-{(S)-2-(4-tert-Butylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-(4-Cyclopropylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-(4-Cyclohexylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenyl-propanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-(4,5-Dimethylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenyl-propanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-(4-Ethyl-5-methylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenyl-propanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-[4-(2,2,2-trifluoroethyl)thiazol-2-yl]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido)-2-[4-(3,3,3-trifluoropropyl)thiazol-2-yl]ethyl}phenylsulfamic acid;
4-{(S)-2-[4-(2,2-Difluorocyclopropyl)thiazol-2-yl]-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-[4-(methoxy-methyl)thiazol-2-yl]ethyl}phenylsulfamic acid;
4-{(S)-2-(4-(Ethoxycarbonyl)thiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-(5-phenylthiazol-2-yl)ethyl}phenylsulfamic acid;
4-{(S)-2-(4-Ethyl-5-phenylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenyl-propanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-[4-(3,4-Dimethylphenyl)thiazol-2-yl]-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-[4-(4-Chlorophenyl)thiazol-2-yl]-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-[4-(thiophen-2-yl)thiazol-2-yl]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-[4-(thiophen-3-yl)thiazol-2-yl]ethyl}phenylsulfamic acid;
4-{(S)-2-(5,6-Dihydro-4H-cyclopenta[d]thiazol-2-yl)-2-[(S)-2-(methoxy-carbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-(4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)ethyl}phenylsulfamic acid;
4-{(S)-2-[4-(5-Chlorothiophen-2-yl)thiazol-2-yl]-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Ethoxycarbonylamino)-3-phenylpropanamido]-2-(4-ethylthiazol-2-yl)ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-(2-ethylthiazol-4-yl)ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-(2-methylthiazol-4-yl)ethyl}phenylsulfamic acid;
4-{(S)-2-(2-Ethylthiazole-4-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropan-amido]ethyl}phenylsulfamic acid;
4-{(S)-2-(2-Isopropylthiazol-4-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropan-amido]ethyl}phenylsulfamic acid;
4-{(S)-2-(2-Cyclopropylthiazol-4-yl)-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-{2-[(4-Chlorophenylsulfonyl)methyl]thiazol-4-yl}-2-[(S)-2-(methoxy-carbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-[2-(tert-Butylsulfonylmethyl)thiazol-4-yl]-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropionamido]-2-(2-phenylthiazole-4-yl)ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid;
4-{(S)-2-[2-(3-Chlorothiophen-2-yl)thiazol-4-yl]-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-[2-(3-methylthiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid;
4-{[(S)-2-(2-(Furan-2-yl)thiazol-4-yl]-2-[(S)-2-(methoxycarbonylamino)-3-phenylpropanamido]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-[2-(2-methylthiazole-4-yl)thiazole-4-yl]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-(2-pyrazine-2-yl)thiazole-4-yl}phenylsulfamic acid; and
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-3-phenylpropanamido]-2-[2-(6-methylpyridin-3-yl)thiazol-4-yl]ethyl}phenylsulfamic acid.
41. A compound chosen from:
4-[(S)-2-((S)-2-Acetamido-3-phenylpropanamido)-2-(4-ethylthiazol-2-yl)ethyl]phenylsulfamic acid;
4-[(S)-2-((S)-2-Acetamido-3-phenylpropanamido)-2-(4-tert-butylthiazol-2-yl)ethyl]phenylsulfamic acid;
4-{(S)-2-((S)-2-Acetamido-3-phenylpropanamido)-2-[4-(thiophen-3-yl)thiazol-2-yl]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(tert-Butoxycarbonylamino)-3-methylbutanamido]-2-(4-ethylthiazol-2-yl)ethyl}phenylsulfamic acid;
(S)-4-{2-[2-(tert-Butoxycarbonylamino)acetamido]-2-(4-ethylthiazol-2-yl)ethyl}phenyl-sulfamic acid;
(S)-4-{2-(4-Ethylthiazol-2-yl)-2-[2-(methoxycarbonylamino)acetamido]ethyl}phenyl-sulfamic acid;
4-{(S)-2-(4-Ethylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-3-methylbutanamido]-ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(tert-Butoxycarbonylamino)-4-methylpentanamido]-2-(4-ethylthiazol-2-yl)ethyl}phenylsulfamic acid;
4-{(S)-2-(4-Ethylthiazol-2-yl)-2-[(S)-2-(methoxycarbonylamino)-4-methylpentan-amido]ethyl}phenylsulfamic acid;
4-{(S)-2-[(S)-2-(tert-Butoxycarbonylamino)-4-methylpentanamido]-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid; and
4-{(S)-2-[(S)-2-(Methoxycarbonylamino)-4-methylpentanamido]-2-[2-(thiophen-2-yl)thiazol-4-yl]ethyl}phenylsulfamic acid.
42. A compound of the formula:
wherein R is a substituted or unsubstituted thiazolyl unit having the formula:
R 4 and R 5 are each independently chosen from:
i) hydrogen;
ii) substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl;
iii) substituted or unsubstituted phenyl; and
iv) substituted or unsubstituted heteroaryl; or
R 4 and R 5 can be taken together to form a saturated or unsaturated ring having from 5 to 7 atoms;
said substitutions are independently chosen from one or more C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl, halogen, hydroxyl, or cyano units;
R 6 is a unit chosen from:
i) hydrogen;
ii) substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl;
iii) substituted or unsubstituted phenyl; and
iv) substituted or unsubstituted heteroaryl;
R 2 is chosen from:
i) C 1 -C 6 linear or branched alkyl; or
ii) C 1 -C 6 linear or branched alkoxy.
43. A compound chosen from:
[1-(S)-(Phenylthiazol-2-yl)-2-(4-sulfoaminophenyl)ethyl]-carbamic acid tert-butyl ester;
(S)-4-(2-(4-Methylthiazol-2-yl)-2-pivalamidoethyl)phenylsulfamic acid;
(S)-4-(2-(4-Ethylthiazole-2-yl)-2-pivalamideoethyl)phenylsulfamic acid;
(S)—N-(1-(4-Hydroxymethyl)thiazole-2-yl)-2pivalamidoethyl)phenylsulfamic acid;
(S)-4-(2-(4-Ethoxycarbonyl)thiazole-2-yl)-2-pivalamideoethyl)phenylsulfamic acid;
(S)-4-(2-(4-Phenylthiazole-2-yl)-2-pivalamidoethyl)phenylsulfamic acid;
4-((S)-2-(4-(3-Methoxyphenyl)thiazol-2-yl)-2-pivalamidoethyl)phenylsulfamic acid;
N—((S)-1-(4-(4-Chlorophenyl)thiazol-2-yl)-2-(4-nitrophenyl)ethyl)pivalamide;
4-((S)-2-(4-(3-methoxyphenyl)thiazol-2-yl)-2-pivalamidoethyl)phenylsulfamic acid;
4-((S)-2-(4-(2,4-Dimethoxyphenyl)thiazol-2-yl)-2-pivalamidoethyl)phenyl-sulfamic acid;
(S)-4-(2-(4-benzylthiazol-2-yl)-2-pivalamidoethyl)phenylsulfamic acid;
(S)-4-(2-Pivalamido-2-(4-(thiophen-2-ylmethyl)thiazol-2-yl)ethyl)phenylsulfamic acid;
(S)-4-(2-(4-(3-Methoxybenzyl)thiazol-2-yl)-2-pivalamidoethyl)phenylsulfamic acid;
4-((S)-2-(4-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)thiazol-2-yl)-2-pivalamidoethyl)phenylsulfamic acid;
(S)-4-(2-(5-Methyl-4-phenylthiazol-2-yl)-2-pivalamidoethyl)phenylsulfamic acid;
(S)-4-(2-(4-(4-Biphenyl)thiazol-2-yl)-2-pivalamidoethyl)phenylsulfamic acid;
(S)-4-(2-(tert-Butoxycarbonylamino)-2-(4-propylthiazol-2-yl)ethyl)-phenyl sulfamic acid;
(S)-4-(2-(tert-Butoxycarbonylamino)-2-(4-tert-butylthiazol-2-yl)ethyl)-phenyl sulfamic acid; and
(S)-4-(2-(tert-Butoxycarbonylamino)-2-(4-(methoxymethyl)thiazol-2-yl)ethyl)-phenyl sulfamic acid.
44. A pharmaceutical composition comprising:
A) one or more compounds of the formula:
wherein R is a substituted or unsubstituted thiazolyl unit having the formula:
R 4 and R 5 are each independently chosen from:
i) hydrogen;
ii) substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl;
iii) substituted or unsubstituted phenyl; and
iv) substituted or unsubstituted heteroaryl; or
R 4 and R 5 can be taken together to form a saturated or unsaturated ring having from 5 to 7 atoms;
said substitutions are independently chosen from one or more C 1 -C 6 linear, or branched alkyl, or C 3 -C 6 cyclic alkyl, halogen, hydroxyl, or cyano units;
R 6 is a unit chosen from:
i) hydrogen;
ii) substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl;
iii) substituted or unsubstituted phenyl; and
iv) substituted or unsubstituted heteroaryl;
R 1 is chosen from:
i) hydrogen;
ii) C 1 -C 6 linear or branched alkyl;
iii) substituted or unsubstituted phenyl; or
iv) substituted or unsubstituted benzyl;
R 2 is chosen from:
i) C 1 -C 6 linear or branched alkyl; or
ii) C 1 -C 6 linear or branched alkoxy;
R 3 is hydrogen or C 1 -C 4 linear or branched alkyl;
or a pharmaceutically acceptable salt thereof, and
B) one or more excipients or carriers.
45. A compound of the formula:
wherein R is a substituted or unsubstituted thiazolyl unit having the formula:
R 2 is chosen from:
i) C 1 -C 6 linear or branched alkyl; or
ii) C 1 -C 6 linear or branched alkoxy;
R 4 and R 5 are each independently chosen from:
i) hydrogen;
ii) substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl;
iii) substituted or unsubstituted phenyl;
iv) substituted or unsubstituted heteroaryl; or
R 4 and R 5 can be taken together to form a saturated or unsaturated ring having from 5 to 7 atoms;
R 6 is a unit chosen from:
i) hydrogen;
ii) substituted or unsubstituted C 1 -C 6 linear or branched alkyl, or C 3 -C 6 cyclic alkyl;
iii) substituted or unsubstituted phenyl; and
iv) substituted or unsubstituted heteroaryl.
46. A pharmaceutical composition comprising:
A) one or more compounds according to claim 39 ; and
B) one or more excipients or carriers.
47. A compound according to claim 39 , wherein the compound is a pharmaceutically acceptable salt of either basic groups or acid groups.
48. A compound according to claim 47 , wherein the compounds are salts comprising anions chosen from chloride, bromide, iodide, sulfate, bisulfate, carbonate, bicarbonate, phosphate, formate, acetate, propionate, butyrate, pyruvate, lactate, oxalate, malonate, maleate, succinate, tartrate, fumarate, and citrate.
49. A compound according to claim 47 , wherein the compounds are salts comprising cations chosen from ammonium, sodium, lithium, potassium, calcium, magnesium, and bismuth.