Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
View Patent ↗The present invention teaches a foamable pharmaceutical carrier comprising a benefit agent, selected from the group consisting of a dicarboxylic acid and a dicarboxylic acid ester; a stabilizer selected from the group consisting of at least one surface-active agent; at least one polymeric agent and mixtures thereof; a solvent selected from the group consisting of water, a hydrophilic solvent, a hydrophobic solvent, a potent solvent, a polar solvent, a silicone, an emollient, and mixtures thereof, wherein the benefit agent, stabilizer and solvent are selected to provide a composition that is substantially resistant to aging and to phase separation and or can substantially stabilize other active ingredients. The invention further relates to a foamable composition further containing a liquefied hydrocarbon gas propellant.
1. A foamable composition comprising a formable carrier and a propellant, the foamable carrier comprising:
a) about 15% by weight of an azelaic acid;
b) about 11% by weight of medium-chain triglycerides;
c) about 11% by weight of propylene glycol;
d) about 5% by weight of dimethyl isosorbide;
e) about 3% by weight of PEG-40 stearate;
f) about 1% by weight of a cetostearyl alcohol;
g) about 1% by weight of polysorbate 80;
h) about 0.5% by weight of a monoglyceride, a diglyceride, or a combination;
i) about 0.3% by weight of a xanthan gum;
j) about 0.1% by weight of methylcellulose;
k) about 0.1% by weight of a benzoic acid;
l) water;
m) sodium hydroxide; and
wherein the pH of said foamable carrier is about 4.5-5.3; and
wherein the propellant is at a concentration of about 3% to about 25% by weight of the total composition.
2. The foamable composition of claim 1 , wherein the medium-chain triglycerides are caprylic/capric triglycerides.
3. The foamable composition of claim 1 , wherein the monoglyceride is glyceryl stearate.
4. The foamable composition of claim 1 , wherein the medium-chain triglycerides are caprylic/capric triglycerides and the monoglyceride is glyceryl stearate.
5. A foamable carrier comprising:
a) about 15% by weight of an azelaic acid;
b) about 11% by weight of medium-chain triglycerides;
c) about 11% by weight of propylene glycol;
d) about 5% by weight of dimethyl isosorbide;
c) about 3% by weight of PEG-40 stearate;
f) about 1% by weight of a cetostearyl alcohol;
g) about 1% by weight of polysorbate 80;
h) about 0.5% by weight of a monoglyceride, a diglyceride, or a combination thereof;
i) about 0.3% by weight of a xanthan gum;
j) about 0.1% by weight of methylcellulose;
k) about 0.1% by weight of a benzoic acid;
l) water;
m) sodium hydroxide; and
wherein the pH of said foamable carrier is about 4.5-5.3.
6. The foamable carrier of claim 5 , wherein the medium-chain triglycerides are caprylic/capric triglycerides.
7. The foamable carrier of claim 5 , wherein the monoglyceride is glyceryl stearate.
8. The foamable carrier of claim 5 , wherein the medium-chain triglycerides are caprylic/capric triglycerides and the monoglyceride is glyceryl stearate.