Use of carrageenan in an enzyme flush
View Patent ↗The present disclosure is directed to methods and compositions for clearing and cleaning enteral feeding tubes. More particularly, the composition is an ingestible gel composition that comprises enzymes for degrading buildup in enteral feeding tubes, carrageenan, and divalent metal ions or a source thereof. The carrageenan present in the composition stabilizes the enzymes at room temperatures, allowing for long-term storage of the composition. Upon injecting the gelled composition into the feeding tube, body heat from the patient melts the gel, and the enzymes are released to act on debris present in the feeding tube.
1. A method of clearing and cleaning the lumen of a feeding tube, the method comprising injecting an ingestible gel composition into the feeding tube, the ingestible gel composition comprising iota carrageenan, a divalent metal ion or source thereof, and from about 20% (w/v) to about 40% (w/v) of an enzyme for degrading buildup in the tube, wherein the composition has a viscosity of at least about 9,000 centipoise at room temperature, and a viscosity of about 4,000 or less at body temperature.
2. The method of claim 1 wherein the composition comprises from about 0.5% (w/v) to about 2.0% (w/v) carrageenan.
3. The method of claim 1 wherein the divalent metal ion is selected from the group consisting of calcium, magnesium, beryllium, strontium, barium, and combinations thereof.
4. The method of claim 3 wherein the divalent metal ion is a calcium ion.
5. The method of claim 1 wherein the composition comprises from about 0.01% (w/v) to about 1.0% (w/v) of the divalent metal ion.
6. The method of claim 1 wherein the enzyme is selected from the group consisting of protease, lipase, cellulase, amylase, and combinations thereof.
7. The method of claim 1 wherein the enzyme is selected from the group consisting of papain, lipase, cellulase, and combinations thereof.
8. The method of claim 7 wherein the composition comprises about 40% (w/v) of papain at 600,000 TU/g.
9. The method of claim 7 wherein the composition comprises about 40% (w/v) of lipase at 200,000 FIP/g.
10. The method of claim 7 wherein the composition comprises about 20% (w/v) of cellulase at 150,000 CU/g.
11. The method of claim 1 wherein the enzymes degrade protein, starch, cellulose, lipids, and combinations thereof present in the lumen of the tube.
12. The method of claim 1 wherein the composition further comprises from about 5% (w/v) to about 40% (w/v) water.
13. The method of claim 1 wherein the composition has a pH of from about 3 to about 7.
14. A method of clearing and cleaning the lumen of a feeding tube, the method comprising injecting an ingestible gel composition into the feeding tube, the ingestible gel composition comprising from about 0.5% (w/v) to about 2.0% (w/v) of iota carrageenan, from about 0.01% (w/v) to about 1.0% (w/v) of a divalent metal ion or source thereof, and from about from about 20% (w/v) to about 40% (w/v) of an enzyme for degrading buildup in the tube.
15. The method of claim 14 wherein the composition has a viscosity of at least about 9,000 centipoise at room temperature, and a viscosity of about 4,000 or less at body temperature.
16. The method of claim 15 wherein the divalent metal ion is a calcium ion.
17. The method of claim 16 wherein the composition comprises about 0.015% (w/v) of calcium ion and about 1.0% (w/v) iota carrageenan.