The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods and compositions suitable for therapeutic applications.
1. A method to treat a condition selected from the group consisting of benign prostatic hyperplasia, prostate cancer and breast cancer in a mammal in need thereof comprising administering to the mammal an effective amount of a group 8 compound having the structure
2. The method of claim 1 wherein the compound has the structure
3. The method of claim 2 wherein the mammal is a human.
4. The method of claim 3 wherein the condition is benign prostatic hyperplasia.
5. The method of claim 3 wherein the condition is prostate cancer.
6. The method of claim 3 wherein the condition is breast cancer.