Prostate and breast cancer treatment
View Patent ↗The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods and compositions suitable for therapeutic applications.
1. A pharmaceutical formulation comprising one or more excipients and group 2 compound selected from the group consisting of
2. The pharmaceutical formulation of claim 1 wherein the compound is
3. The pharmaceutical formulation of claim 1 wherein the compound is
4. The pharmaceutical formulation of claim 1 wherein the compound is
5. The pharmaceutical formulation of claim 1 wherein the pharmaceutical formulation is a dosage form for oral or parenteral administration.
6. A pharmaceutical formulation comprising one or more excipients and a group 3 compound selected from the group consisting of
7. The pharmaceutical formulation of claim 6 wherein the compound is
8. The pharmaceutical formulation of claim 6 wherein the compound is
9. The pharmaceutical formulation of claim 6 wherein the compound is
10. The pharmaceutical formulation of claim 6 wherein the pharmaceutical formulation is a dosage form for oral or parenteral administration.
11. A pharmaceutical formulation comprising one or more excipients and a group 6 compound selected from the group consisting of
wherein R 24 is —H, —CH 2 OH, —CH 2 OC(O)CH 3 , —OC(O)CH 3 or —CH 2 )C(O)OCH 3 .
12. The pharmaceutical formulation of claim 11 wherein the compound is
13. The pharmaceutical formulation of claim 11 wherein the compound is
14. The pharmaceutical formulation of claim 11 wherein the compound is
15. The pharmaceutical formulation of claim 11 wherein R 24 is —CH 2 OH.
16. The pharmaceutical formulation of claim 11 wherein the pharmaceutical formulation is a dosage form for oral or parenteral administration.
17. A compound wherein the compound is
(a) a group 2 compound selected from the group consisting of
(b) a group 3 compound selected from the group consisting of
(b) a group 6 compound selected from the group consisting of
wherein R 24 is —H, —CH 2 OH, —CH 2 OC(O)CH 3 , —OC(O)CH 3 or —CH 2 )C(O)OCH 3 .
18. The compound of claim 17 wherein the compound is in the form of a powder or granule.