Breast and prostate cancer treatment method
View Patent ↗The invention provides methods to treating conditions such as prostate cancer, or for ameliorating one or more symptoms associated with prostate cancer, or for agents that modulate the biological activity of the androgen receptor. The invention also provides methods and compositions suitable for therapeutic applications.
1. A compound having the structure
wherein
R 6 is —OH or —O—C(O)—CH 3 ;
R 17 is —OH or —O—C(O)—CH 3 ;
R 18 is —OH or —O—C(O)—CH 3 ;
R 19 is —H; and
R 24 is —CH 3 or —CH 2 OH, wherein the compound is a purified and isolated solid.
2. The compound of claim 1 wherein the compound has the structure
3. The compound of claim 2 wherein the solid is a powder or granules.
4. The compound of claim 2 wherein the compound has the structure
5. The compound of claim 4 wherein the solid is a powder or granules.
6. The compound of claim 1 wherein the compound has the structure
7. The compound of claim 6 wherein the solid is a powder or granules.
8. A compound having the structure
wherein
R 6 is —OH or —O—C(O)—CH 3 ;
R 16 is —OH or —O—C(O)—CH 3 ;
R 18 is —OH or —O—C(O)—CH 3 ;
R 19 is —CCH; and
R 24 is —CH 3 .
9. The compound of claim 8 wherein the compound has the structure
10. The compound of claim 9 wherein the compound is a solid.
11. The compound of claim 8 wherein the compound has the structure
12. The compound of claim 11 wherein the compound is a solid.
13. The compound of claim 8 wherein the compound has the structure
14. The compound of claim 8 wherein the compound has the structure
15. A pharmaceutical formulation comprising one or more excipients and a compound having the structure
wherein
R 6 is —OH or —O—C(O)—CH 3 ;
R 16 is —OH or —O—C(O)—CH 3 ;
R 18 is —OH or —O—C(O)—CH 3 ;
R 19 is —CCH; and
R 24 is —CH 3 .
16. The pharmaceutical formulation of claim 15 wherein the pharmaceutical formulation is a formulation for oral, parenteral, aerosol or topical administration.
17. The pharmaceutical formulation of claim 15 wherein the compound has the structure
18. The pharmaceutical formulation of claim 15 wherein the pharmaceutical formulation is a formulation for oral, parenteral, aerosol or topical administration.
19. The pharmaceutical formulation of claim 15 wherein the compound has the structure
20. The pharmaceutical formulation of claim 19 wherein the pharmaceutical formulation is a formulation for oral, parenteral, aerosol or topical administration.
21. The pharmaceutical formulation of claim 15 wherein the compound has the structure
22. The pharmaceutical formulation of claim 21 wherein the pharmaceutical formulation is a formulation for oral, parenteral, aerosol or topical administration.
23. The pharmaceutical formulation of claim 15 wherein the compound has the structure
24. The pharmaceutical formulation of claim 23 wherein the pharmaceutical formulation is a formulation for oral, parenteral, aerosol or topical administration.