USE OF CD23 ANTAGONISTS FOR THE TREATMENT OF NEOPLASTIC DISORDERS
Methods and kits for the treatment of neoplastic disorders comprising the use of a CD23 antagonist are provided. The CD23 antagonist may be used alone or in combination with chemotherapeutic agents. In particularly preferred embodiments the CD23 antagonists may be used to treat B cell chronic lymphocytic leukemia (B-CLL).
1 - 54 . (canceled)
55 . A method of enhancing cytotoxicity in chronic lymphocytic leukemia cells, wherein the cytotoxicity is induced by a chemotherapeutic agent, comprising contacting CD23 expressing cells with an anti-CD23 antibody.
56 . The method of claim 55 , wherein the anti-CD23 antibody is a human, humanized, or chimeric antibody.
57 . The method of claim 56 , wherein the anti-CD23 antibody comprises a human gamma 1 heavy chain constant region.
58 . The method of claim 56 , wherein the anti-CD23 antibody comprises a human kappa light chain constant region.
59 . The method of claim 56 , wherein the anti-CD23 antibody comprises variable regions of antibody 5E8.
60 . The method of claim 59 , wherein the anti-CD23 antibody comprises human constant regions.
61 . The method of claim 60 , wherein the anti-CD23 antibody is IDEC-152.
62 . The method of claim 55 , wherein the anti-CD23 antibody enhances antibody-dependent cell-mediated cytotoxicity (ADCC) of chronic lymphocytic leukemia cells.
63 . The method of claim 55 , wherein the anti-CD23 antibody enhances apoptosis of chronic lymphocytic leukemia cells.
64 . The method of claim 55 , wherein the anti-CD23 antibody is capable of inhibiting the binding to CD23 of a monoclonal antibody having light chain and heavy chain variable domains of antibody 5E8.
65 . The method of claim 64 , wherein the anti-CD23 antibody comprises human constant regions.
66 . The method of claim 64 , wherein the anti-CD23 antibody enhances antibody-dependent cell-mediated cytotoxicity (ADCC) of chronic lymphocytic leukemia cells.
67 . The method of claim 64 , wherein the anti-CD23 antibody enhances apoptosis of chronic lymphocytic leukemia cells.
68 . The method of claim 55 , wherein the cytotoxicity is induced by an antibody.
69 . The method of claim 68 , wherein the antibody is an anti-CD19 antibody, an anti-CD20 antibody, an anti-CD22 antibody, an anti-CD40 antibody, an anti-CD40L antibody, an anti-CD52 antibody, or an anti-B7 antibody.
70 . The method of claim 69 , wherein the antibody is an anti-CD20 antibody or an anti-CD52 antibody.
71 . The method of claim 70 , wherein the anti-CD20 antibody is rituximab.
72 . The method of claim 55 , wherein the cytotoxicity is induced by cyclophosphamide, chlorambucil, or fludarabine.
73 . The method of claim 55 , wherein the CD23 expressing cells are contacted with the anti-CD23 antibody in vivo.