Ophthalmic Pharmaceutical Compositions and Uses Thereof
A composition for providing relief to a discomfort of an eye comprises a pharmaceutically acceptable carrier and a material that allows the composition to remain in an ocular environment for an extended period of time. The composition can further comprise an active ingredient selected from the group consisting of anti-allergic agents, anti-inflammatory agents, anti-infective agents, and combinations thereof.
1 . A composition comprising a material that is capable of allowing the composition to remain in an ocular environment for an extended period of time after said composition has been administered thereto, wherein said composition has a osmolality of about 200-260 mOsm/kg, and a pH of about 6.5-7.5.
2 . The composition of claim 1 , wherein said material comprises a carboxyl-containing polymer.
3 . The composition of claim 2 , wherein said carboxyl-containing polymer comprises from about 0.01 to about 5% by weight of the composition.
4 . The composition of claim 3 , wherein said polymer comprises polyacrylic acid.
5 . The composition of claim 4 , wherein the composition is devoid of preservatives that produce other discomfort to the eye.
6 . The composition of claim 1 , further comprising a viscosity-modifying compound.
7 . The composition of claim 6 , wherein said viscosity-modifying compound is selected from the group consisting of glycerol, cellulose derivatives, and combinations thereof.
8 . The composition of claim 7 , wherein the composition is devoid of preservatives that produce other discomfort to the eye.
9 . The composition of claim 2 , further comprising a viscosity-modifying compound.
10 . The composition of claim 2 , further comprising an active ingredient selected from the group consisting of anti-allergic agents, anti-inflammatory agents, anti-infective agents, and combinations thereof.
11 . The composition of claim 6 , further comprising an active ingredient selected from the group consisting of anti-allergic agents, anti-inflammatory agents, anti-infective agents, and combinations thereof.
12 . A method for providing relief to a discomfort of an eye, the method comprising administering to an environment of an affected eye a composition that comprises a material that is capable of allowing the composition to remain in an ocular environment for an extended period of time after said composition has been administered thereto, wherein said composition has a osmolality of about 200-260 mOsm/kg, and a pH of about 6.5-7.5, in an amount and at a frequency sufficient to provide said relief.
13 . The method of claim 12 , wherein said carboxyl-containing polymer comprises from about 0.01 to about 5% by weight of the composition.
14 . The method of claim 13 , wherein said polymer comprises polyacrylic acid.
15 . The method of claim 12 , further comprising a viscosity-modifying compound.
16 . The method of claim 15 , wherein said viscosity-modifying compound is selected from the group consisting of glycerol, cellulose derivatives, and combinations thereof.
17 . A method for producing a composition that is capable of providing relief to a discomfort of an eye, the method comprising combining a pharmaceutically acceptable carrier with a material that is capable of allowing said composition to remain in an ocular environment for an extended period of time after said composition has been administered to said ocular environment, to produce said composition, wherein said composition has osmolality of about 200-260 mOsm/kg and pH of about 6.5-7.5.
18 . The method of claim 17 , wherein said carboxyl-containing polymer comprises from about 0.01 to about 5% by weight of the composition.
19 . The method of claim 18 , wherein said polymer comprises polyacrylic acid.
20 . The method of claim 17 , further comprising including a viscosity-modifying compound in said composition.
21 . The method of claim 20 , wherein said viscosity-modifying compound is selected from the group consisting of glycerol, cellulose derivatives, and combinations thereof