IP Library Granted Patent US 8,382,744
Granted Patent B2
US 8,382,744 · App. 11/843,498 · Granted Feb 26, 2013

Method and device for cornea reshaping by intrastromal tissue removal

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Quick Facts
Patent No.
US 8,382,744
App. No.
11/843,498
Granted
Feb 26, 2013
Kind
B2
Abstract

A method and device for flapless, intrastromal keratomileusis for the correction of myopia, hyperopia and astigmatism, i.e., for vision correction by corneal reshaping without creating a flap. Ultra-short laser pulses are used to create a temporary micro-channel extending to an end point located within the cornea. A second series of ultra-short laser pulses are then delivered to photo-ablate material in the vicinity of the micro-channel end-point. The photo-ablated material may exit through the micro-channel used to deliver the laser pulses, or via a separate micro-channel. With the micro-channel oriented substantially normal to the optical axis of the cornea, and by continuing to supply the ultra-short laser pulses in the appropriate number while moving the point of ablation along the micro-channel, the photo-ablation of the intrastromal tissue may continue in a controlled fashion and the cornea reshaped in a predetermined manner without creating a flap.

Claims (6)

1. A method for removing material from an interior portion of a cornea without creating a flap, said method comprising the steps of:

creating a temporary micro-channel extending from a surface of said cornea to a micro-channel end point located within said cornea by delivering a first plurality of ultra-short laser pulses; and

multi photon ablating material in a vicinity of said micro-channel end point by delivering a second plurality of ultra-short laser pulses with pulse energies of 20 μJ or greater and focused down to a pulse intensity between a range of 10 13 to 10 15 W/cm 2 .

2. The method of claim 1 wherein said micro-channel is oriented substantially normal to the optical axis of said cornea.

3. The method of claim 2 wherein said first plurality of ultra-short laser pulses forming said micro-channel are delivered in a first window of time, are directed substantially normal to the optical axis of said cornea, have a pulse duration of 500 femtoseconds or less, have a pulse energy of 5 mJ or less, have a repetition rate of 1 kHz or greater and are focused down to a diameter of between 50 and 100 μm, and wherein said second plurality of ultra-short laser pulses is are delivered in a second window of time.

4. The method of claim 3 wherein each pulse of said second plurality of ultra-short laser pulses is directed substantially normal to said optical axis, and wherein said multi-photon ablating creates an over-pressure within the ablated area of the cornea causing an outflow of said ablated material in the form of a gas or liquid via said micro-channel.

Assignments (14)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 23, 2018
From: LIGHTSENSE IP LTD.
To: FEMTO VISION LTD.
Reel/Frame 045608/0790 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE NAME PREVIOUSLY RECORDED AT REEL: 038899 FRAME: 0516. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jun 28, 2016
From: SMITS, ALEXANDER
To: LIGHTSENSE IP LTD
Reel/Frame 039196/0053 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE NAME PREVIOUSLY RECORDED ON REEL 038890 FRAME 0987. ASSIGNOR(S) HEREBY CONFIRMS THE LIGHTSENSEIP LTD. Recorded Jun 28, 2016
From: SUCKEWER, SZYMON
To: LIGHTSENSE IP LTD
Reel/Frame 039185/0821 →
CORRECTIVE ASSIGNMENT TO CORRECT THE THE NAME OF THE ASSIGNEE PREVIOUSLY RECORDED ON REEL 038891 FRAME 0010. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jun 28, 2016
From: MOROZOV, ANATOLI
To: LIGHTSENSE IP LTD
Reel/Frame 039196/0713 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE NAME PREVIOUSLY RECORDED AT REEL: 038891 FRAME: 0005. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jun 28, 2016
From: HERSH, PETER
To: LIGHTSENSE IP LTD
Reel/Frame 039196/0972 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 13, 2016
From: SMITS, ALEXANDER, SMIT
To: LIGHTSENSEIP LLP
Reel/Frame 038899/0516 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 11, 2016
From: HERSH, PETER
To: LIGHTSENSEIP LLP
Reel/Frame 038891/0005 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 11, 2016
From: SUCKUWER, SZYMON
To: LIGHTSENSEIP LLP
Reel/Frame 038890/0987 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 11, 2016
From: MOROZOV, ANATOLI
To: LIGHTSENSEIP LLP
Reel/Frame 038891/0010 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 8, 2016
From: TRUSTEES OF PRINCETON UNIVERSITY
To: SUCKEWER, SZYMON; HERSH, PETER; SMITS, ALEXANDER; MOROZOV, ANATOLI, MORO
Reel/Frame 038925/0604 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 13, 2014
From: MOROZOV, ANATOLI
To: THE TRUSTEES OF PRINCETON UNIVERSITY
Reel/Frame 033939/0376 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 11, 2014
From: SUCKEWER, SZYMON
To: THE TRUSTEES OF PRINCETON UNIVERSITY
Reel/Frame 033933/0936 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 11, 2014
From: HERSH, PETER
To: THE TRUSTEES OF PRINCETON UNIVERSITY
Reel/Frame 033933/0956 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 11, 2014
From: SMITS, ALEXANDER
To: THE TRUSTEES OF PRINCETON UNIVERSITY
Reel/Frame 033933/0948 →