Pharmaceutical compositions comprising an anti-teratogenic compound and applications of the same
View Patent ↗Pharmaceutical compositions comprising anti-teratogenic agents are disclosed. Additionally, pharmaceutical compositions comprising anti-neoplastic agents and anti-teratogenic agents are disclosed. Methods of assessing the teratogenicity of a compound are disclosed. The present invention further comprises applications of the aforementioned compositions and methods.
1. A method of inhibiting the teratogenicity of an anti-neoplastic agent, the method comprising administering a pharmaceutical composition comprising Noggin.
2. A method of inhibiting the teratogenicity of an anti-neoplastic agent, the method comprising administering a pharmaceutical composition comprising an anti-Dkk1 antibody.
3. A method of inhibiting the teratogenicity of an anti-neoplastic agent, the method comprising administering a pharmaceutical composition comprising LiCl or Gsk3-Inhibitor IX.
4. The method of claim 1 , wherein the anti-neoplastic agent is thalidomide or lenalidomide.
5. The method of claim 2 , wherein the anti-neoplastic agent is thalidomide or lenalidomide.
6. The method of claim 3 , wherein the anti-neoplastic agent is thalidomide or lenalidomide.
7. The method of claim 1 , further comprising administering a pharmaceutical composition comprising an anti-Dkk1 antibody.
8. The method of claim 2 , further comprising administering a pharmaceutical composition comprising Noggin.