Hypernucleophilic catalysts for detoxification of chemical threat agents
View Patent ↗A polymeric hypernucleophilic catalyst is effective for hydrolytic destruction of chemical threat agents under mild conditions, e.g., near neutral pH and at ambient temperatures. The polymeric hypernucleophilic catalysts are particularly useful to affect rapid destruction of chemical threat agents on sensitive surfaces such as paint, metal, rubber, plastic, fabric, wood, and skin. Catalyst formulations such as creams, lotions, sprays, foams, powders, or gels, and articles such as filters, wipes, membranes, yarns, fabrics, and articles of clothing, may be used for detoxification of or prophylactic protection against chemical threat agents.
1. A method of detoxifying a chemical threat agent, the method comprising applying a polymeric hypernucleophilic catalyst to a surface selected from the group consisting of paint, metal, fabric, wood, rubber, plastic, and skin, to establish contact between the polymeric hypernucleophilic catalyst and the chemical threat agent under conditions sufficient for hydrolytic destruction of the chemical threat agent, wherein the polymeric hypernucleophilic catalyst comprises a repeating aminopyridine moiety having an unsubstituted ring nitrogen.
2. The method of claim 1 , wherein the chemical threat agent is selected from the group consisting of nerve agents, blister agents, mustard agents, and toxic industrial chemicals/materials.
3. The method of claim 2 wherein the chemical threat agent is selected from the group consisting of nerve agents, phosgene, ethylene oxide, methyl isocyanate, and mustard agents.
4. The method of claim 1 , wherein the conditions sufficient for hydrolytic destruction of the chemical threat agent include a pH of about 6 to about 8.
5. The method of claim 4 , wherein the pH ranges from about 7 to about 8.
6. The method of claim 1 , wherein the conditions sufficient for hydrolytic destruction of the chemical threat agent include a pH of about 6 to about 9.
7. The method of claim 1 , wherein the polymeric hypernucleophilic catalyst is based on the reaction of 4-chloropyridine with diallylamine to form a diallylamine pyridine monomer, followed by radical polymerization.
8. The method of claim 1 , wherein the polymeric hypernucleophilic catalyst is based on the reaction of 4-chloropyridine with polyethylenimine.
9. A method of prophylacticly protecting a surface from a chemical threat agent, the method comprising applying a polymeric hypernucleophilic catalyst to a surface selected from the group consisting of paint, metal, fabric, wood, rubber, plastic, and skin, to permit contact between the polymeric hypernucleophilic catalyst and the chemical threat agent wherein the polymeric hypernucleophilic catalyst comprises a repeating aminopyridine moiety having an unsubstituted ring nitrogen.
10. A composition for detoxifying or prophylacticly protecting a surface against a chemical threat agent, the composition comprising an effective amount of a polymeric hypernucleophilic catalyst and one or more excipients, wherein the polymeric hypernucleophilic catalyst comprises a repeating aminopyridine moiety having an unsubstituted ring nitrogen, and wherein the composition is formulated as a spray, lotion, cream, gel, foam, concentrate, or solution.
11. The composition of claim 10 , wherein the one or more excipients comprises a polymer latex.
12. The composition of claim 11 which is an aqueous solution containing latex polymer particles.
13. The composition of claim 10 , wherein the polymeric hypernucleophilic catalyst is based on the reaction of 4-chloropyridine with diallylamine to form a diallylamine pyridine monomer, followed by radical polymerization.
14. The composition of claim 10 , wherein the polymeric hypernucleophilic catalyst is based on the reaction of 4-chloropyridine with polyethylenimine.
15. An article for detoxifying or prophylacticly protecting a surface against a chemical threat agent, the article comprising an effective amount of a polymeric hypernucleophilic catalyst attached to a fabric or membrane through reactive alcohol or amine functionality so as to permit contact between the polymeric hypernucleophilic catalyst and the chemical threat agent, wherein the polymeric hypernucleophilic catalyst comprises a repeating aminopyridine moiety having an unsubstituted ring nitrogen, and wherein the article is a filter, wipe, membrane, yarn, fabric, latex paint film or article of clothing.
16. The article of claim 15 which is a cotton/polyester blend fabric.
17. The article of claim 15 which is a cotton/nylon blend fabric.
18. The article of claim 15 which is a nominally dry fabric treated with the polymeric hypernucleophilic catalyst.
19. The article of claim 15 which is a latex paint film.
20. The article of claim 15 , wherein the polymeric hypernucleophilic catalyst is based on the reaction of 4-chloropyridine with diallylamine to form a diallylamine pyridine monomer, followed by radical polymerization.
21. The article of claim 15 , wherein the polymeric hypernucleophilic catalyst is based on the reaction of 4-chloropyridine with polyethylenimine.