Creatine-fatty acids
View Patent ↗The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty compounds bound by an amide linkage, or mixtures thereof produced by reacting creatine or derivatives thereof with an appropriate fatty acid in the presence of dichloromethane and a pyridine catalyst, previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
1. A method for producing creatine fatty acids comprising at least the steps of:
mixing an excess of a thionyl halide with a fatty acid to form an acyl halide;
said acyl halide then being added to a dichloromethane suspension of creatine in the presence of a pyridine catalyst; and
isolating the resulting creatine fatty acid.
2. The method of claim 1 wherein the halide of the thionyl halide is selected from the group consisting of fluorine, chlorine, bromine, and iodine.
3. The method of claim 1 wherein the acyl halide is produced at temperatures from between about 35° C. to about 50° C.
4. The method of claim 1 wherein the acyl halide and the suspension of creatine in dichloromethane are reacted at temperatures from between about −15° C. to room temperature.
5. The method of claim 1 wherein the creatine fatty acid is isolated by filtration followed by removal of the dichloromethane under reduced pressure.
6. The method of claim 1 wherein the creatine fatty acid has the general structure of:
wherein R is selected from the group consisting of alkanes and alkenes;
said alkanes and alkenes having from 3 to 21 carbons.