Creatine-fatty acids
View Patent ↗The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting creatine or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.
1. A method for producing creatine fatty acids comprising at least the steps of:
mixing an excess of a thionyl halide with a fatty acid to form an acyl halide;
neutralizing the carboxylic acid of a creatine with an inorganic base to form a creatine salt;
said acyl halide then being reacted with the creatine salt; and
isolating the resulting creatine fatty acid.
2. The method of claim 1 wherein the halide of the thionyl halide is selected from the group consisting of fluorine, chlorine, bromine, and iodine.
3. The method of claim 1 wherein the acyl halide is produced at temperatures from between about 35° C. to about 50° C.
4. The method of claim 1 wherein the inorganic base is selected group consisting of sodium hydroxide, potassium hydroxide, lithium hydroxide, ammonium hydroxide, sodium carbonate.
5. The method of claim 1 wherein the creatine fatty acid is isolated by distillation.
6. The method of claim 1 wherein the creatine fatty acid has the general structure of:
wherein R is selected from the group consisting of alkanes and alkenes;
said alkanes and alkenes having from 3 to 21 carbons.