Poly(ADP-ribose)polymerase inhibitors
View Patent ↗Compounds which inhibit the activity of poly(ADP-ribose)polymerase, compositions containing the compounds and methods of treating diseases using the compounds is disclosed.
1. A compound having formula (I)
or a salt thereof, wherein
A 1 is C(O)NH 2 ;
A 2 , A 3 and A 4 are hydrogen;
R 1 is alkyl, alkenyl or alkynyl, each of which is unsubstituted or substituted with one or two of three of independently selected CF 3 , CF 2 CF 3 , F, Cl, Br or I;
A 5 is R 2 ;
R 2 is phenyl;
wherein R 2 is substituted with R 10 ;
R 10 is R 13 ;
R 13 is C 4 -cycloalkyl, piperidinyl or piperazinyl; and
R 13 is unsubstituted or substituted with alkyl.
2. The compound of claim 1 selected from the group consisting of
3-oxo-2-(4-piperidin-4-ylphenyl)-2,3-dihydro-1H-isoindole-4-carboxamide;
3-oxo-2-(4-piperidin-1-ylphenyl)-2,3-dihydro-1H-isoindole-4-carboxamide;
3-oxo-2-(3-piperidin-4-ylphenyl)-2,3-dihydro-1H-isoindole-4-carboxamide;
2-(4-(4-methylpiperazin-1-yl)phenyl)-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide; and
2-(3-(1-methylpiperidin-4-yl)phenyl)-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide.
3. A composition comprising a therapeutically acceptable amount of compound having formula (I) of claim 1 , or a salt thereof, and an excipient.