Modulation of Pericyte Proliferation
Methods and materials for modulating pericyte and epithelial cell proliferation relating to BPI protein products or inhibitors thereof are provided.
1 . A method of enhancing pericyte cell proliferation comprising administering to a subject in need thereof an amount of a BPI protein product effective to enhance proliferation of pericyte cells.
2 - 4 . (canceled)
5 . The method of claim 1 wherein the subject is suffering from age related macular degeneration (ARMD).
6 - 19 . (canceled)
20 . The method of claim 1 wherein the BPI protein product is an amino-terminal fragment of BPI protein having a molecular weight of about 20 kD to 25 kD, or a dimeric form thereof.
21 . The method of claim 1 wherein the BPI protein product is a BPI-derived peptide.
22 . The method of claim 21 wherein the BPI-derived peptide is XMP.679.
23 - 34 . (canceled)
35 . A method of enhancing pericyte proliferation in a subject suffering from a pericyte degeneration disorder that is age related macular degeneration (ARMD), comprising administering to the subject an amount of a BPI protein product effective to enhance proliferation of pericytes.
36 - 39 . (canceled)