Automated sampling system
View Patent ↗A sample carrier having a top wall, a base, and a support wall joining the top wall and the base. The top wall includes aligned, spaced-apart openings on at least one side of the support wall which are sized to receive sample tubes. Sleeves depending from the top wall and circumscribing each opening direct sample tubes into sample tube holding areas. The sample tube holding areas each include one or more retaining walls extending upward from the base opposite the support wall. Springs extending outward from the support wall bias sample tubes against the retaining walls. A drip shield comprising a cover plate, a pair of through-holes for accessing sample tubes in the sample carrier, and a depending fin which separates sample tubes on opposite sides of the support wall protects against cross-contamination between sample tubes held by the sample carrier.
1. An automated sampling system comprising:
a conveyor;
a sample carrier positioned on the conveyor and comprising:
a top wall having two sets of generally parallel openings formed therein, each of the openings being dimensioned to receive a sample tube therethrough;
a base defining two sets of generally parallel sample tube holding areas, each of the sample tube holding areas corresponding to one of the openings in the top wall and adapted to hold a sample tube in a substantially fixed, vertical orientation therebelow;
a support wall joining the top wall and the base, wherein the two sets of sample tube holding areas are located on opposite sides of the support wall; and
a plurality of sample tubes, wherein each of the two sets of sample tube holding areas holds a subset of the plurality of sample tubes;
a drip shield in fixed position above the conveyor and comprising:
a cover plate;
a fin depending from the cover plate and constructed and arranged to limit vertical movement of the sample carrier when it is positioned beneath the drip shield; and
one or more through-holes formed in the cover plate on each side of the fin, the through-holes being operatively aligned with the plurality of sample tubes held on opposite sides of the support wall as the sample carrier is indexed by the conveyor under the cover plate, each of the through-holes being sized to provide vertical passage by a robotic pipettor; and
a robotic pipettor operatively positioned for accessing the contents of sample tubes located beneath the through-holes.
2. The automated sampling system of claim 1 , wherein the openings in the top wall are of the same or different sizes.
3. The automated sampling system of claim 1 , wherein the sample carrier and the drip shield have corresponding arcuate shapes.
4. The automated sampling system of claim 1 , wherein one or both ends of the fin are tapered.
5. The automated sampling system of claim 1 , wherein the diameter of each through-hole on each side of the fin is less than the smallest diameter of the sample tubes operatively aligned therewith.
6. The automated sampling system of claim 1 , wherein the conveyor is a rotatable carousel.
7. The automated sampling system of claim 6 , wherein the sample carrier is one of a plurality of sample carriers positioned on the carousel.
8. The automated sampling system of claim 7 , wherein each of the sample carriers is seated in a sample carrier receiving well of the carousel.
9. The automated sampling system of claim 1 , wherein the sample carrier further comprises a plurality of sleeves, each of the plurality of sleeves depending from a bottom surface of the top wall and circumscribing one of the openings, and each of the plurality of sleeves having an inner surface dimensioned to receive a vessel component of a sample tube therethrough.
10. The automated sampling system of claim 9 , wherein each of the plurality of sleeves includes an opening configured and arranged to permit viewing of a label affixed to a sample tube contained thereby.
11. The automated sampling system of claim 9 , wherein a cap component of each of the plurality of sample tubes is in touching contact with an inner surface of the corresponding sleeve.
12. The automated sampling system of claim 11 , wherein the cap component of each of the plurality of sample tubes is permitted to move laterally no more than about 0.125 inches by the corresponding sleeve.
13. The automated sampling system of claim 11 , wherein the cap component of each of the plurality of sample tubes is permitted to move laterally no more than about 0.1 inches by the corresponding sleeve.
14. The automated sampling system of claim 1 , wherein the top wall has upwardly flared edges to facilitate handling of the sample carrier.
15. The automated sampling system of claim 14 , wherein the flared edges of the top wall include a plurality of recesses, each recess being adjacent one of the openings to provide finger access to sample tubes held by the sample carrier.
16. The automated sampling system of claim 1 further comprising end walls joined to the base and a plurality of partitions, each partition extending radially or perpendicularly outward from the support wall and separating adjacent sample tube holding areas.
17. The automated sampling system of claim 16 , wherein each partition and a pair of retaining walls are joined to form a Y-shaped divider.
18. The automated sampling system of claim 1 , wherein the sample carrier further comprises a plurality of springs extending outward from the support wall, each spring being associated with one of the sample tube holding areas and configured and arranged to bias a sample tube against one or more retaining walls of the associated sample tube holding area.
19. The automated sampling system of claim 18 , wherein each spring is a leaf spring.
20. The automated sampling system of claim 19 , wherein the springs are positioned between upper and lower portions of the support wall.