Ophthalmic compositions containing diglycine

1. An ophthalmic composition comprising diglycine, or a salt thereof,

10 ppm of α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride, and

boric acid and one or more borate salts, wherein the ophthalmic composition has an osmolality of from 200 mOsmol/kg to 420 mOsmol/kg.

2. The ophthalmic composition of claim 1 further comprising a sulphobetaine surfactant of the formula

wherein R 1 and R 2 are independently selected from a C 1 -C 4 alkyl;

A is an unsubstituted or a substituted alkylene with two to four carbons, and m is an integer from 2 to 4;

Y is a straight or branched alkyl, or a straight or branched alkene, with eight to sixteen carbons; and

Z is —SO 3 − or —CO 2 − , preferably Z is —SO 3 − .

3. The composition of claim 1 further comprising dexpanthenol, sorbitol, aspartic acid, glycolic acid, 2-amino-2-methyl-1,3-propanediol or any mixture thereof.

4. The composition of claim 1 further comprising a hydroxypropylmethyl cellulose.

5. The composition of claim 1 further comprising propylene glycol or myristamidopropyl dimethylamine.

6. The composition of claim 1 further comprising hyaluronic acid or a salt thereof.

7. The composition of claim 1 further comprising a disuccinate of formula

or a corresponding salt thereof; wherein R 1 is selected from hydrogen, alkyl or —C(O)alkyl, the alkyl having one to twelve carbons and optionally having one or more oxygen atoms; and

A is a methylene group or an oxyalkylene group, and n is from 2 to 10.

8. The composition of claim 1 wherein the boric acid is present from 0.15% w/v to 0.6% w/v, and the one or more borate salts are selected from sodium or potassium borate from 0.05% w/v to 0.5% w/v, and the diglycine is present from 0.1% w/v to 0.7% w/v.

9. The use of the composition of claim 1 to clean, disinfect or package contact lenses, or to preserve an ophthalmic composition.

10. An ophthalmic composition comprising:

boric acid from 0.15% w/v to 0.6% w/v, sodium or potassium borate from 0.05% w/v to 0.5% w/v, and diglycine from 0.1% w/v to 0.7% w/v;

10 ppm of α-[4-tris(2-hydroxyethyl)ammonium chloride-2-butenyl]poly[1-dimethylammonium chloride-2-butenyl]-ω-tris(2-hydroxyethyl)ammonium chloride; and

myristamidopropyl dimethylamine;

wherein the ophthalmic composition has an osmolality of from 200 mOsmol/kg to 420 mOsmol/kg.

11. The composition of claim 10 further comprising a disuccinate of formula

or a corresponding salt thereof; wherein R 1 is selected from hydrogen, alkyl or —C(O)alkyl, the alkyl having one to twelve carbons and optionally having one or more oxygen atoms; and

A is a methylene group or an oxyalkylene group, and n is from 2 to 10.