Biaryl ether urea compounds

1. A compound of Formula I

wherein:

each R 1 is independently hydrogen, —OH, halogen, haloalkyl, —C 1 -C 6 alkyl, —O—C 1 -C 6 alkyl, —S—C 1 -C 6 alkyl, aryl, heteroaryl, —O-aryl, —O-heteroaryl, —NH 2 , —NHC(O)C 1 -C 6 alkyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl, —NHC(O)C 3 -C 6 cycloalkyl, —NHC 1 -C 6 alkyl, CN, —C(O)NR′R″ or —C(O)C 1 -C 6 alkyl; with each R 1 —C 1 -C 6 alkyl group being optionally substituted by an —O—C 1 -C 6 alkyl group or from 1 to 3 —OH substituents;

R′ and R″ are independently selected from H or C 1 -C 6 alkyl;

R 2 is pyridazine;

each R 3 is independently hydrogen, halogen, haloalkyl, —C 1 -C 6 alkyl, —O—C 1 -C 6 alkyl, —S—C 1 -C 6 alkyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl, —S—C 3 -C 6 cycloalkyl and —O—C 3 -C 6 cycloalkyl; said R 3 —C 1 -C 6 alkyl, —O—C 1 -C 6 alkyl, —S—C 1 -C 6 alkyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl, —S—C 3 -C 6 cycloalkyl and —O—C 3 -C 6 cycloalkyl, groups are optionally substituted with from 1 to 4 halogen, haloalkyl, —O-haloalkyl, —C 1 -C 6 alkyl, or —O(C 1 -C 6 alkyl) substituents;

R 4 is hydrogen, —C 1 -C 6 alkyl, phenyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl or halogen; said R 4 —C 1 -C 6 alkyl, phenyl, and —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl groups being optionally substituted with from 1 to 4 halogen, —C 1 -C 6 alkyl, or —O(C 1 -C 6 alkyl) substituents;

X is N or CH;

m is 0, 1, 2, 3, or 4;

n is 0, 1, 2, 3 or 4; and

Ar is aryl, —CH 2 -aryl, or heteroaryl, with said aryl, —CH 2 -aryl and heteroaryl groups being optionally independently substituted with from 1 to 4 substituents selected from hydrogen, —C 1 -C 6 alkyl, —C 2 -C 6 alkenyl, —C 2 -C 6 alkynyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl, halogen, haloalkyl, —O-haloalkyl, —C(O)C 1 -C 6 alkyl, —O—C 1 -C 6 alkyl, —S—C 1 -C 6 alkyl, —O—C 2 -C 6 alkenyl, —O—C 2 -C 6 alkynyl, CN, aryl, heterocyclyl or heteroaryl; said —C 1 -C 6 alkyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl, —C(O)C 1 -C 6 alkyl, —O(C 1 -C 6 alkyl), —S—C 1 -C 6 alkyl, aryl, —CH 2 -aryl, heterocyclyl and heteroaryl substituents on Ar are optionally independently substituted with from 1 to 4 —C 1 -C 6 alkyl, —C 1 -C 6 alkoxy, —OH, or halogen substituents;

or a pharmaceutically acceptable salt thereof.

2. A compound according to claim 1 wherein Ar is phenyl, pyrimidinyl, pyridyl, benzothiazolyl; and R 2 is pyridazinyl; m is 0, 1 or 2; n is 0 to 2; and X is C or CH; or a pharmaceutically acceptable salt thereof.

3. A compound according to claim 1 having Formula III:

wherein:

each R 1 is independently hydrogen, —C 1 -C 6 alkyl, or —O(C 1 -C 6 alkyl);

R 2 is a pyridazine;

each R 3 is independently hydrogen, halogen, —C 1 -C 6 alkyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl, or —O—C 1 -C 6 alkyl;

R 4 is hydrogen, —C 1 -C 6 alkyl, phenyl, or halogen;

each R 5 is independently hydrogen, halogen, haloalkyl, —O-haloalkyl, —C 1 -C 6 alkyl, —C(O)C 1 -C 6 alkyl, —O—C 1 -C 6 alkyl, —S—C 1 -C 6 alkyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl, CN, aryl, and heteroaryl; said —C 1 -C 6 alkyl, —O(C 1 -C 6 alkyl), —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl, aryl, and heteroaryl groups are optionally independently substituted with from 1 to 4-C 1 -C 6 alkyl, —OH, or halogen substituents;

m is 0, 1, 2, 3, or 4;

n is 0, 1, 2, 3 or 4;

p is 0, 1, 2, 3, or 4 and

Z 1 and Z 2 are independently selected from N, or CH;

or a pharmaceutically acceptable salt thereof.

4. A compound according to claim 3 wherein Z 1 is N; Z 2 is CH; p is 1; R 5 is CF 3 ; and R 1 is hydrogen.

5. A compound according to claim 1 , or a pharmaceutically acceptable salt thereof, which is:

N-pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxamide;

N-(pyridazin-4-yl)-4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxamide;

N-(6-methoxypyridazin-3-yl)-4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxamide;

N-(pyridazin-3-yl)-4-(3-{[phenyl]oxy}benzylidene)piperidine-1-carboxamide;

4-(3-(5-bromopyridin-2-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-(3-(5-bromopyrimidin-2-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-(3-(5-cyclopropylpyridin-2-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-(3-(6-methylpyridin-2-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-(3-(3-methylpyridin-2-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-(3-(5-methylpyridin-2-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-(3-(5-ethoxypyridin-2-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-(3-(5-(2,2,2-trifluoroethoxy)pyridin-2-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-(3-(5-isopropoxypyridin-2-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-(3-(4-(trifluoromethyl)phenoxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-(3-(6-(trifluoromethyl)pyridin-3-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-(3-bromo-5-(5-(trifluoromethyl)pyridin-2-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-(3-cyclopropyl-5-(5-(trifluoromethyl)pyridin-2-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-{3-[(4-methylpyridin-2-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

N-(6-chloropyridazin-3-yl)-4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxamide;

4-(3-(5-(pyrrolidin-1-yl)pyridin-2-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-(3-(5-(azetidin-1-yl)pyridin-2-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-(3-(5-(pent-4-ynyloxy)pyridin-2-yloxy)benzylidene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-((6-phenoxypyridin-2-yl)methylene)-N-(pyridazin-3-yl)piperidine-1-carboxamide;

4-{3-[(5-fluoropyridin-2-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-{3-[(6-methoxy-2-methylpyridin-3-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

N-pyridazin-3-yl-4-{3-[4-(2,2,2-trifluoroethoxy)phenoxy]benzylidene}piperidine-1-carboxamide;

4-{3-[(8-methoxyquinazolin-2-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

N-pyridazin-3-yl-4-[3-(pyrido[2,3-d]pyrimidin-2-yloxy)benzylidene]piperidine-1-carboxamide;

N-pyridazin-3-yl-4-[3-(pyrimidin-2-yloxy)benzylidene]piperidine-1-carboxamide;

4-(3-{[5-(4-methoxyphenyl)pyrimidin-2-yl]oxy}benzylidene)-N-pyridazin-3-ylpiperidine-1-carboxamide;

N-pyridazin-3-yl-4-[3-(quinazolin-2-yloxy)benzylidene]piperidine-1-carboxamide;

4-{3-[(5-cyclopropylpyrimidin-2-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-{3-[(5-ethylpyrimidin-2-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-{3-[(5-fluoropyrimidin-2-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-{3-[(5-methylpyrimidin-2-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-(3-{[5-(3-chlorophenyl)pyrimidin-2-yl]oxy}benzylidene)-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-{3-[(5-propylpyrimidin-2-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-{3-[(4-isopropyl-5-methylpyrimidin-2-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

N-pyridazin-3-yl-4-(3-{[4-(trifluoromethyl)pyrimidin-2-yl]oxy}benzylidene)piperidine-1-carboxamide;

4-{3-[(2,7-dimethyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-(3-{[6-ethyl-2-(trifluoromethyl)pyrimidin-4-yl]oxy}benzylidene)-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-(3-{[6-methyl-4-(trifluoromethyl)pyridin-2-yl]oxy}benzylidene)-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-(3-{[5-(morpholin-4-ylcarbonyl)pyridin-2-yl]oxy}benzylidene)-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-{3-[(3-methylpyrazin-2-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-{3-[(4-methylphthalazin-1-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-{3-[(4,6-dimethylpyrimidin-2-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-{3-[(6-methoxypyrimidin-4-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

N-pyridazin-3-yl-4-[3-(quinoxalin-2-yloxy)benzylidene]piperidine-1-carboxamide;

4-[3-(pyrazin-2-yloxy)benzylidene]-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-[3-(1,3-benzothiazol-2-yloxy)benzylidene]-N-pyridazin-3-ylpiperidine-1-carboxamide;

4-{3-[(3-phenyl-1,2,4-thiadiazol-5-yl)oxy]benzylidene}-N-pyridazin-3-ylpiperidine-1-carboxamide;

or a pharmaceutically acceptable salt thereof.

6. A pharmaceutical composition comprising a compound of claim 1 , and a pharmaceutically acceptable excipient.

7. The compound N-pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxamide or a pharmaceutically acceptable salt thereof.

8. A pharmaceutical composition comprising N-pyridazin-3-yl-4-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}benzylidene)piperidine-1-carboxamide or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient.

9. A compound according to claim 1 having Formula IV:

wherein:

each R 1 is independently hydrogen, —C 1 -C 6 alkyl, or —O(C 1 -C 6 alkyl);

R 2 is pyridazinyl;

each R 3 is independently hydrogen, halogen, —C 1 -C 6 alkyl, —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl, or —O—C 1 -C 6 alkyl;

R 4 is hydrogen, —C 1 -C 6 alkyl, phenyl, or halogen;

R 5 is hydrogen, halogen, haloalkyl, —C 1 -C 6 alkyl, or —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl; and said —C 1 -C 6 alkyl is optionally substituted with from 1 to 4 —OH substituents and —(CH 2 ) 0-3 —C 3 -C 6 cycloalkyl is optionally substituted by from 1 to 4 halogen or —OH substituents;

m is 0, 1 or 2;

n is 0, 1, 2, 3 or 4;

Z 1 is selected from N or CH;

or a pharmaceutically acceptable salt thereof.

10. A compound of claim 9 wherein R 5 is selected from hydrogen, halogen, —C 1 -C 6 alkyl, —CF 3 or —C 3 -C 6 cycloalkyl; or a pharmaceutically acceptable salt thereof.