IP Library › Patent Application 11879187
Patent Application
App. No. 11/879,187

Methods and compositions for treatment of ocular neovascularization and neural injury

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Quick Facts
Patent No.
US None
App. No.
11/879,187
Abstract

Methods and compositions for the treatment of ocular neovascularization and macular degeneration. The invention includes combining photodynamic therapy with administration of a neuroprotectant and a neovascularization inhibitor.

Claims (10)

1 . A method of protecting or preventing ocular neural tissue from damage caused by laser-aided occlusion of ocular blood vessels comprising delivering a composition to a patient's ocular neural tissue, the composition comprising an amount of memantine or a salt or ester thereof, effective to protect a plurality of ocular neurons from cell death caused by a photoactive component of the PDT treatment as compared to the degree of ocular neuron cell death observed in the absence of the administration of said amount of brimonidine.

2 . The method of claim 1 wherein said composition is administered at a time sufficiently before said laser-aided occlusion treatment to permit localization within ocular tissue prior to said treatment.

3 . The method of claim 1 wherein said composition is administered intravenously.

4 . The method of claim 1 wherein said composition is administered by intraocular injection.

5 . The method of claim 1 wherein said composition is administered by subretinal injection.

6 . The method of claim 1 wherein said composition is administered by intravitreal injection.

7 . The method of claim 1 wherein said laser-aided occlusion method is a photodynamic therapy treatment.

8 . The method of claim 2 wherein said laser-aided occlusion method is a photodynamic therapy treatment.

9 . The method of claim 1 wherein said laser-aided occlusion method is a photocoagulation treatment.

10 . The method of claim 2 wherein said laser-aided occlusion method is a photocoagulation treatment.