Methods and systems relating to mitochondrial DNA information
The present application relates, in general, to a system or a method for detection or treatment. In some aspects, a system includes at least one computer program for use with at least one computer system and wherein the computer program includes a plurality of instructions including but not limited to one or more instructions for making at least one correlation between mitochondrial DNA information regarding at least one person and information regarding at least one clinical trial involving the at least one person.
1 . A method comprising:
determining at least one correlation between at least one aspect of mitochondrial DNA information regarding at least one individual and information regarding at least one clinical outcome following receipt by the at least one individual of at least one medical therapy.
2 . The method of claim 1 , wherein the determining at least one correlation further comprises:
determining at least one statistical correlation.
3 . The method of claim 1 , wherein the determining at least one correlation further comprises:
counting the occurrence of at least one clinical outcome.
4 . The method of claim 1 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding mitochondrial DNA sequence.
5 . The method of claim 1 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding heteroplasmy.
6 . The method of claim 1 , wherein at least one aspect of mitochondrial DNA information further comprises:
information regarding one or more maternal relatives of the at least one individual.
7 . (canceled)
8 . The method of claim 1 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding at least one tissue source.
9 . (canceled)
10 . (canceled)
11 . The method of claim 1 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding mosaicism of at least one individual.
12 . (canceled)
13 . (canceled)
14 . The method of claim 1 , wherein the receipt by the at least one individual of at least one medical therapy includes treatment with at least one therapeutic agent.
15 . (canceled)
16 . (canceled)
17 . The method of claim 1 , wherein the receipt by the at least one individual of at least one medical therapy is pursuant to at least one clinical trial.
18 . (canceled)
19 . The method of claim 18 , further comprising:
creating at least one inclusion criterion and at least one exclusion criterion for a clinical trial involving the at least one medical therapy.
20 . (canceled)
21 . (canceled)
22 . The method of claim 1 , further comprising:
using one or more of the at least one correlation to predict at least one clinical outcome regarding at least one second individual.
23 . (canceled)
24 . (canceled)
25 . The method of claim 1 , further comprising:
wherein the at least one second individual is a plurality of people; and
determining the eligibility of the at least one second individual for at least one clinical trial.
26 . A method of predicting a clinical outcome of at least one medical therapy for at least one first individual, comprising:
determining a similarity or a dissimilarity in at least one aspect of mitochondrial DNA information regarding the at least one first individual to at least one aspect of mitochondrial information regarding at least one second individual, wherein the at least one second individual attained a clinical outcome following receipt of the at least one medical therapy.
27 . The method of claim 26 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding mitochondrial DNA sequence.
28 . The method of claim 26 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding heteroplasmy.
29 . The method of claim 26 , wherein at least one aspect of mitochondrial DNA information further comprises:
information regarding one or more maternal relatives of the at least one individual.
30 . (canceled)
31 . The method of claim 26 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding at least one tissue source.
32 . (canceled)
33 . (canceled)
34 . The method of claim 26 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding mosaicism of at least one individual.
35 . (canceled)
36 . (canceled)
37 . The method of claim 26 , wherein the at least one medical therapy includes treatment with at least one therapeutic agent.
38 . (canceled)
39 . (canceled)
40 . The method of claim 26 , wherein the at least one medical therapy is pursuant to at least one clinical trial.
41 . The method of claim 26 , further comprising:
using one or more of the similarity in at least one aspect of epigenetic information to predict at least one clinical outcome regarding at least one first individual.
42 . The method of claim 26 , further comprising:
using one or more of the dissimilarity in at least one aspect of epigenetic information to predict at least one clinical outcome regarding at least one first individual.
43 . (canceled)
44 . The method of claim 26 , further comprising:
wherein the at least one individual is a plurality of people; and
determining the eligibility of the at least one second individual for at least one clinical trial.
45 . A system comprising:
at least one computer program for use with at least one computer system and wherein the computer program includes a plurality of instructions including but not limited to:
one or more instructions for determining at least one correlation between at least one aspect of mitochondrial DNA information regarding at least one individual and information regarding at least one clinical outcome following receipt by the at least one individual of at least one medical therapy.
46 . The system of claim 45 , wherein the one or more instructions for determining at least one correlation further comprises:
one or more instructions for determining at least one statistical correlation.
47 . The system of claim 45 , wherein the one or more instructions for determining at least one correlation further comprises:
one or more instructions for counting the occurrence of at least one clinical outcome.
48 . The system of claim 45 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding mitochondrial DNA sequence.
49 . The system of claim 45 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding heteroplasmy.
50 . The system of claim 45 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding one or more maternal relatives of the at least one individual.
51 . The system of claim 45 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding a plurality of people.
52 . The system of claim 45 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding at least one tissue source.
53 . (canceled)
54 . (canceled)
55 . The system of claim 45 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding mosaicism of at least one individual.
56 . The system of claim 45 , wherein the receipt by at least one individual of at least one medical therapy comprises treatment with at least one medical device.
57 . The system of claim 45 , wherein the receipt by at least one individual of at least one medical therapy comprises treatment with at least one surgical procedure.
58 . The system of claim 45 , wherein the receipt by at least one individual of at least one medical therapy comprises treatment with at least one therapeutic agent.
59 . (canceled)
60 . (canceled)
61 . The system of claim 45 , wherein the receipt by at least one individual of at least one medical therapy is pursuant to at least one clinical trial.
62 . The system of claim 45 , wherein the one or more instructions for determining at least one correlation further comprises:
one or more instructions for determining at least one correlation before the onset of the at least one medical therapy.
63 . The system of claim 62 , further comprising:
one or more instructions for creating at least one inclusion criterion and at least one exclusion criterion for a clinical trial involving at least one medical therapy.
64 . (canceled)
65 . (canceled)
66 . The system of claim 45 , further comprising:
one or more instructions for using one or more of the at least one correlation to predict at least one clinical outcome regarding at least one second individual.
67 . The system of claim 66 , wherein the at least one second individual has not received the at least one medical therapy.
68 . (canceled)
69 . The system of claim 45 , further comprising:
one or more instructions wherein the at least one second individual is a plurality of people; and
one or more instructions for determining the eligibility of the at least one second individual for at least one clinical trial.
70 . A system for predicting a clinical outcome of at least one medical therapy for at least one first individual, comprising:
at least one computer program for use with at least one computer system and wherein the computer program includes a plurality of instructions including but not limited to:
one or more instructions for determining a similarity or a dissimilarity in at least one aspect of mitochondrial DNA information regarding the at least one first individual to at least one aspect of mitochondrial DNA information regarding at least one second individual, wherein the at least one second individual attained a clinical outcome following receipt of the at least one medical therapy.
71 . The system of claim 70 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding mitochondrial DNA sequence.
72 . The system of claim 70 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding heteroplasmy.
73 . The system of claim 70 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding one or more maternal relatives of the at least one individual.
74 . (canceled)
75 . The system of claim 70 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding at least one tissue source.
76 . (canceled)
77 . (canceled)
78 . The system of claim 70 , wherein the at least one aspect of mitochondrial DNA information further comprises:
information regarding mosaicism of at least one individual.
79 . The system of claim 70 , wherein the at least one medical therapy comprises treatment with at least one medical device.
80 . The system of claim 70 , wherein the at least one medical therapy comprises treatment with at least one surgical procedure.
81 . The system of claim 70 , wherein the at least one medical therapy comprises treatment with at least one therapeutic agent.
82 . (canceled)
83 . (canceled)
84 . The system of claim 70 , wherein the at least one medical therapy is pursuant to at least one clinical trial.
85 . The system of claim 70 , further comprising:
one or more instructions for using one or more of a similarity in at least one aspect of epigenetic information to predict at least one clinical outcome regarding at least one first individual.
86 . The system of claim 70 , further comprising:
one or more instructions for using one or more of a dissimilarity in at least one aspect of epigenetic information to predict at least one clinical outcome regarding at least one first individual.
87 . (canceled)
88 . The system of claim 70 , further comprising:
one or more instructions wherein the at least one second individual is a plurality of people; and
one or more instructions for determining the eligibility of the at least one second individual for at least one clinical trial.
89 . A system comprising:
at least one computer program for use with at least one computer system and wherein the computer program includes a plurality of instructions including but not limited to:
one or more instructions for making one or more correlations between at least one aspect of mitochondrial DNA information obtained regarding at least one individual and information regarding at least one medical therapy involving the at least one individual; and
one or more instructions for applying one or more of the one or more correlations to at least one aspect of mitochondrial DNA information obtained regarding a plurality of people.
90 . The system of claim 89 , further comprising:
one or more instructions for segregating individual identifiers associated with the plurality of people in reference to at least one of the one or more applied correlations.
91 . The system of claim 89 , wherein the at least one medical therapy includes at least one investigational therapeutic agent.
92 . The system of claim 89 , wherein the at least one aspect of mitochondrial DNA information includes mitochondrial DNA sequence information.
93 . The system of claim 89 , wherein the at least one aspect of mitochondrial DNA information includes information from two or more individuals with a common attribute.
94 . (canceled)
95 . The system of claim 89 , wherein the at least one aspect of mitochondrial DNA information includes information regarding at least one tissue source.
96 . The system of claim 89 , further comprising:
one or more instructions for segregating individual identifiers associated with the plurality of people in reference to at least one characteristic shared by two or more individuals of the plurality of people.