Combination of anticholineric and β mimetics for the treatment of respiratory diseases
View Patent ↗The present invention describes a combination of an anticholinergic, such as R,R-glycopyrrolate, and a β mimetic, such as tormoterol, for the treatment of respiratory diseases including airway inflammation or obstruction such as chronic obstructive pulmonary disease (COPD) and asthma.
1. A method for the treatment of chronic obstructive pulmonary disease (COPD) or asthma in a patient suffering from COPD or asthma comprising administration of a combination of R,R-glycopyrrolate and formoterol or physiologically acceptable salt(s) thereof.
2. The method of claim 1 wherein the daily dose of R,R-glycopyrrolate is between 5 and 500 μg.
3. The method of claim 1 wherein the daily dose of formoterol is between 200 and 5,000 μg.
4. The method of claim 1 wherein the combination is administered in an inhalable aerosol.
5. The method of claim 1 wherein the combination is administered in an inhalable dry powder.
6. The method of claim 1 wherein the R,R-glycopyrrolate and formoterol are presented in fixed or free combination for simultaneous, sequential or separate administration, optionally together with a suitable excipient, adjunct or additive in a pharmaceutical form suitable for inhalative application.
7. The method of claim 1 wherein the patient is a human or horse.