Substituted oxindole derivatives, medicaments containing the latter and use thereof

1. A compound of the formula (I):

in which

R 1 is hydrogen, C 1 -C 4 -alkyl, O—(C 1 -C 4 -alkyl), Cl or F;

R 2 is O—C 1 -C 4 -alkyl, C 1 -C 6 -alkyl, or Cl;

R 3 is hydrogen, F, Cl, (CH 2 ) 0-2 —CN, CF 3 , OCF 3 , CONH 2 , CONH(C 1 -C 4 -alkyl), CON(C 1 -C 4 -alkyl)(C 1 -C 4 -alkyl), NHCHO, NHCONH 2 , NH(C 0 -C 4 -alkylene)CONH 2 , NH(C 0 -C 4 -alkylene)CONH(C 1 -C 4 -alkyl), NHCOCH 3 , NO 2 , (CH 2 ) 1-2 —OH, O—C 1 -C 6 -alkyl, (CH 2 ) 1-2 —O—C 1 -C 4 -alkyl, O—C 0 -C 4 -alkylene-phenyl, phenyl, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl or C 2 -C 6 -alkynyl;

B is a cyclic radical selected from the group consisting of the quinolinyl, thienyl, pyridinyl and pyrimidinyl radicals, which may each be substituted by the radicals R 4 and R 5 , where R 4 and R 5 are selected independently of one another from the group consisting of hydrogen, F, Cl, CN, NO 2 , O—C 1 -C 4 -alkyl and C 1 -C 6 -alkyl;

where

B may additionally be substituted by one, two, three or four radicals selected from the group consisting of R 4 , R 5 , R 6 and R 7 , where R 4 , R 5 , R 6 and R 7 are independently of one another and independently of their respective occurrence be selected from the group consisting of hydrogen, Cl, Br, I, F, (CH 2 ) 0-2 —CN, CF 3 , OCF 3 , CONH 2 , CONH(C 1 -C 4 -alkyl), CON(C 1 -C 4 -alkyl)(C 1 -C 4 -alkyl), NHCHO, NH(C 0 -4-alkylene)CONH(C 1 -C 4 -alkyl), NHCOCH 3 , NO 2 , OH, O—C 1 -C 4 -alkyl, (CH 2 ) 0-2 —O—(CH 2 ) 0-3 —CH 3 , O—CO—C 4 -alkylene-phenyl, phenyl, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl and C 2 -C 6 -alkynyl;

W is O, CH 2 or NH;

X is O, NH or N—CN; and

Y 1 is N;

Y 2 is N;

m is 2;

n is 2;

Z is a radical selected from the group consisting of

where

A 2 and A 3 independently of one another are N or C;

A 1 is N, C, O or S;

D 1 , D 2 , D 3 , D 4 and D 5 independently of one another are C or N, but where at least one of the variables D 1 , D 2 , D 3 , D 4 or D 5 is N,

and where

Z may in each case be substituted by the radicals R 8 , R 9 and R 10 , where R 8 , R 9 and R 10 independently of one another have the following meanings, namely

R 8 is hydrogen, Cl, F, CN, CF 3 , OCF 3 , CONH 2 , NHCOCH 3 , NO 2 , OH, OC—C 1 -C 4 -alkyl, C 1 -C 4 -alkyl, NH 2 , NH(C 1 -C 4 -alkyl) or N(C 1 -C 4 -alkyl)(C 1 -C 4 -alkyl);

R 9 is hydrogen, F, Cl, OCH 3 , or C 1 -C 4 -alkyl; and

R 10 is hydrogen;

or a tautomeric, enantiomeric or diastereomeric form, or a physiologically tolerated salt of said compound.

2. The compound of the formula (I) according to claim 1 , in which

R 1 is hydrogen,

R 2 is OCH 2 CH 3 , and

R 3 is hydrogen.

3. A compound according to claim 1 , or a tautomeric, enantiomeric or diastereomeric form, or a physiologically tolerated salt of said compound, selected from the group consisting of:

5-Cyano-3-(2-ethoxyphenyl)-2-oxo-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol-3-yl 4-(thiazol-2-yl)piperazine-1-carboxylate;

4-(Pyridin-4-yl)piperazin-1-[5-cyano-3-(2-ethoxyphenyl)-2-oxo-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol-3-yl]carboxamide;

4-(Pyridin-4-yl)piperazin-1-[5-cyano-3-(2-ethoxyphenyl)-2-oxo-1-(thien-3-yl-sulfonyl)-2,3-dihydro-1H-indol-3-yl]carboxamide;

5-Cyano-3-(2-ethoxyphenyl)-2-oxo-1-(thien-3-ylsulfonyl)-2,3-dihydro-1H-indol-3-yl 4-(pyridin-4-yl)piperazine-1-carboxylate;

5-Cyano-3-(2-ethoxyphenyl)-2-oxo-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol-3-yl 4-(pyridin-2-yl)piperazine-1-carboxylate;

5-Cyano-3-(2-ethoxyphenyl)-2-oxo-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol-3-yl 4-(pyrimidin-2-yl)piperazine-1-carboxylate;

5-Cyano-3-(2-ethoxyphenyl)-2-oxo-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol-3-yl 4-(pyrazin-2-yl)piperazine-1-carboxylate;

5-Cyano-3-(2-ethoxyphenyl)-2-oxo-1-(thien-3-ylsulfonyl)-2,3-dihydro-1H-indol-3-yl 4-(thiazol-2-yl)piperazine-1-carboxylate;

5-Cyano-3-(2-ethoxyphenyl)-2-oxo-1-(thien-3-ylsulfonyl)-2,3-dihydro-1H-indol-3-yl 4-(5-cyanopyridin-2-yl)piperazine-1-carboxylate;

4-(5-Cyanopyridin-2-yl)piperazine-1-[5-cyano-3-(2-ethoxyphenyl)-2-oxo-1-(thien-3-ylsulfonyl)-2,3-dihydro-1H-indol-3-yl]carboxamide;

5-Cyano-3-(2-ethoxyphenyl)-2-oxo-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol-3-yl 4-(5-cyanopyridin-2-yl)piperazine-1-carboxylate; and

5-Cyano-3-(2-ethoxyphenyl)-2-oxo-1-(quinoline-8-sulfonyl)-2,3-dihydro-1H-indol-3-yl 4-(pyridin-4-yl)piperazine-1-carboxylate.

4. A pharmaceutical composition comprising at least one compound of the formula (I) according to claim 1 , and a pharmaceutically acceptable carrier.

5. A method for the treatment of a disease in a mammal in need of such treatment, wherein the disease is selected from the group consisting of arterial hypertension, and congestive heart failure, the method comprising administering an effective amount of at least one compound according to claim 1 to said mammal.