Use of substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines for the treatment of reperfusion injury and reperfusion damage
The invention relates to substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines of formula (I) and their use in medicaments for the prophylaxis and/or treatment of reperfusion injury and damage.
1 . A method for prophylaxis and/or treatment of reperfusion injury and reperfusion damage comprising administering to a subject in need thereof an effective amount of a compound of formula (I)
in which
A represents —O—R 2 or —NH—C(═O)—R 3 ,
R 1 represents CH 2 —C(═O)—NH 2 , pyridyl or thiazolyl,
R 2 represents hydrogen or (C 3 -C 6 )-cycloalkylmethyl,
and
R 3 represents (C 1 -C 4 )-alkyl, (C 1 -C 4 )-alkoxy, mono- or di-(C 1 -C 4 )-alkylamino,
and their salts, hydrates, hydrates of the salts and solvates.
2 . A method according to claim 1 comprising administering to a subject in need thereof an effective amount of a compound of formula (I)
in which
A represents —O—R 2 or —NH—C(═O)—R 3 ,
R 1 represents CH 2 —C(═O)—NH 2 , pyridyl or thiazolyl,
R 2 represents hydrogen or cyclopropylmethyl,
and
R 3 represents methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, iso-butyl or tert.-butyl,
and their salts, hydrates, hydrates of the salts and solvates.
3 . A method according to claim 1 comprising administering to a subject in need thereof an effective amount of a compound of formula (I-A)
and its salts, hydrates, hydrates of the salts and solvates.
4 . A method according to claim 1 comprising administering to a subject in need thereof an effective amount of a compound of formula (I-B)
and its salts, hydrates, hydrates of the salts and solvates.
5 . Compounds of formula (I-C)
in which
A represents —O—R 2 ,
R 1 represents CH 2 —C(═O)—NH 2 , pyridyl or thiazolyl,
and
R 2 represents (C 3 -C 6 )-cycloalkylmethyl,
and their salts, hydrates, hydrates of the salts and solvates.
6 . Compounds according to claim 5 of formula (I-C),
in which
A represents —O—R 2 ,
R 1 represents CH 2 —C(═O)—NH 2 , pyridyl or thiazolyl,
and
R 2 represents cyclopropylmethyl,
and their salts, hydrates, hydrates of the salts and solvates.
7 . Compound according to claims 5 and 6 of the formula (I-B)
and its salts, hydrates, hydrates of the salts and solvates.
8 . A pharmaceutical composition, comprising at least one compound as claimed in claims 5 to 7 and customary auxiliaries and additives.
9 . A method for preparing a medicament comprising at least one compound as claimed in claim 5 to 7 , wherein the active compounds are converted into a suitable administration form using customary auxiliaries and additives.
10 . A method according to one of the claims 1 to 4 , wherein the pharmaceutical is for oral use.
11 . A method according to one of the claims 1 to 5 , wherein the pharmaceutical is for prophylactic use.
12 . A method for prophylaxis and/or treatment of reperfusion injury and/or reperfusion damage of a compound of the general formula (I), as defined in one of the claims 1 to 4 .
13 . Pharmaceutical composition for the treatment of reperfusion injury and reperfusion damage, containing a compound of the general formula (I), as defined in one of the claims 1 to 4 .