Device for dosing and dry nebulization
The invention relates to a device ( 1 ) for dosing and dry nebulization of nebulizable material, comprising a nebulization channel ( 3 ), which has a first attachment piece and a second attachment piece, and a source of compressed carrier gas connected to the first attachment piece via a valve for the purpose of sending a carrier gas pressure pulse into the nebulization channel. The device is characterized in that between the first attachment piece and second attachment piece, and above the nebulization channel, a reservoir open only towards the nebulization channel, and used for receiving the nebulizable material, is connected to the nebulization channel such that it is gas-tight with respect to the environment, and that, when the valve is closed, a pressure compensation takes place in the nebulization channel and in the reservoir. The invention also relates to the use of this device for inhaled administration of a powdered pharmaceutical preparation, and to a method for dosing and dry nebulization of nebulizable material by means of such a device.
1. A device for dosing and dry nebulization of nebulizable material, comprising:
a nebulization channel connected to a source of compressed carrier gas;
a valve configured to send a carrier gas pressure pulse into the nebulization channel;
a reservoir above and open only towards the nebulization channel, the reservoir configured for receiving the nebulizable material and connected to the nebulization channel such that the reservoir is gas-tight with respect to an external environment;
a conical dosing chamber separate from and connecting to the reservoir; and
a capillary tube connecting the valve to the nebulization channel, the capillary tube having an outlet in the nebulization channel in an area under the connection between the reservoir and the nebulization channel, wherein
an inner diameter of the capillary tube is smaller than an inner diameter of the nebulization channel, such that
upon release of the carrier gas pressure pulse the capillary tube and the nebulization channel form a jet pump flowing the carrier gas past the connection between the reservoir and the nebulization channel and generate an underpressure in the reservoir, and wherein
when the valve is closed, a pressure compensation takes place by carrier gas flowing back to the reservoir.
2. The device according to claim 1 , further comprising a dispersing nozzle connected to the nebulization channel.
3. The device according to claim 1 , wherein the valve is a regulated valve.
4. The device according to Claim 1 , wherein the capillary has an internal diameter of 0.8 to 1 mm.
5. The device according to claim 1 , wherein, between pressure pulses, the device is configured to allow respiratory air or ventilation air to flow into the nebulization channel and into the reservoir counter to a direction of the pressure pulse.
6. The device according to claim 1 , further comprising a respirator attachment piece connected to the nebulization channel.
7. The device according to claim 6 , wherein the valve is configured to synchronize a duration and/or time of the carrier gas pressure pulse with a respiratory rate of a respirator.
8. The device according to claim 6 , wherein the nebulization channel concentrically connects to the respirator attachment piece.
9. The device according to claim 1 , further comprising a device connected to the nebulization channel and configured for administration to spontaneously ventilating patients.
10. The device according to claim 9 , wherein the valve is configured to synchronize a duration and/or time of the pressure pulse with a respiratory rate of a patient breathing in via the device for administration to spontaneously ventilating patients.
11. The device according to claim 1 , wherein the nebulization channel is configured such that 30-180 ml of carrier gas can be introduced into the nebulization channel per pressure pulse.
12. The device according to claim 1 , wherein the device is configured such that a predefined amount of the nebulizable material can be nebulized per pressure pulse.
13. The device according to claim 1 , wherein the reservoir is a vial configured for injectable preparations.
14. The device according to claim 1 , wherein the reservoir contains 0.5 to 3 g of nebulizable material.
15. The device according to claim 1 , wherein the nebulizable material comprises a pharmaceutical preparation comprising a lung surfactant.
16. The device according to claim 15 , wherein the lung surfactant is a surfactant based on recombinant surfactant protein C.
17. The device according to claim 16 , wherein the surfactant based on recombinant surfactant protein C is lusupultide.
18. A device for dosing and dry nebulization of nebulizable material, comprising:
a nebulization channel;
a reservoir above and open only towards the nebulization channel, the reservoir configured for containing nebulizable material and connected to the nebulization channel such that the reservoir is gas-tight with respect to an environment;
a capillary tube having a first end and a second end, the first end of the capillary tube having an outlet in an area under the connection between the reservoir and the nebulization channel and the second end of the capillary tube connecting to a valve configured to send a carrier gas pressure pulse through the capillary tube into the nebulization channel; wherein:
an inner diameter of the capillary tube is smaller than an inner diameter of the nebulization channel, such that
upon release of the carrier gas pressure pulse the capillary tube and the nebulization channel form a jet pump generating an underpressure in the reservoir by the carrier gas pressure pulse flowing past the connection between the nebulization channel and the reservoir, and
nebulizable material stored in the reservoir is sucked into the nebulization channel and is nebulized in the channel with the carrier gas pressure pulse, and
when the valve is closed, a pressure compensation takes place by gas flowing back to the reservoir.