Controlled delivery system
View Patent ↗The present invention relates to novel anesthetic compositions containing a non-polymeric carrier material and an anesthetic, where the compositions are suitable for providing a sustained local anesthesia without an initial burst and having a duration for about 24 hours or longer. Certain compositions are also provided that include a first anesthetic and a second anesthetic. In such compositions, the second anesthetic is a solvent for the first anesthetic and provides an initial anesthetic effect upon administration to a subject. The non-polymeric carrier may optionally be a high viscosity liquid carrier material such as a suitable sugar ester. The compositions can further include one or more additional ingredients including active and inactive materials. Methods of using the compositions of the invention to produce a sustained anesthetic effect at a site in a subject are also provided.
1. A pharmaceutical composition for providing sustained local anaesthesia after administration to a subject, said composition comprising:
about 66% by weight sucrose acetate isobutyrate (SAIB) liquid carrier material relative to the total weight of the composition;
about 12% by weight bupivacaine relative to the total weight of the composition; and
about 22% by weight benzyl alcohol (BA) relative to the total weight of the composition,
wherein the bupivacaine is released from the composition for a period of at least 24 hours after administration in an amount sufficient to provide sustained local anesthesia.
2. The composition of claim 1 , wherein the bupivacaine is present in free base form.
3. The composition of claim 1 , wherein said composition is suitable for topical, systemic, or parenteral administration.
4. The composition of claim 1 , wherein said composition is suitable for administration via injection, pouring, spraying, dipping, aerosolizing, or via a coating applicator.