Method and device for repairing the larynx, trachea and other fibrocartilaginous tissues
View Patent ↗Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, trachea, interarticular menisci intervertebral discs, ear, nose, ribs and other fibrocartilaginous tissues in a mammal.
1. A method for repairing a nonarticular cartilage defect comprising the step of administering to the cartilage defect an effective amount of a composition comprising an osteogenic protein selected from the group consisting of osteogenic protein (OP)-1, OP-2, OP-3, bone morphogenetic protein (BMP)-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-9, BMP-10, BMP-11, BMP-15, BMP-3B, decapentaplegic (DPP), vegetal-1 (Vg-1), vegetal-related-1 (Vgr-1), 60A protein, growth/differentiation factor (GDF-1), GDF-2, GDF-3, GDF-7, GDF-8, GDF-9, GDF-10 and GDF-11; and a carrier selected from the group consisting of a liquid, semi-liquid and gel carrier.
2. The method of claim 1 , wherein the osteogenic protein is selected from the group consisting of OP-1, GDF-7, BMP-2, BMP-4, BMP-5 and BMP-6.
3. The method of claim 1 , wherein the osteogenic protein is OP-1.
4. The method of claim 1 , wherein the defect is in a tissue selected from the group consisting of fibrocartilaginous tissue, larynx, trachea, intervertebral disc, interarticular meniscus, ear, a nose and rib.
5. The method of claim 1 , wherein the carrier is selected from the group consisting of poloxamers, gelatins, polyethylene glycols, dextrins, vegetable oils and polymers of lactic acid, butyric acid, and glycolic acid.
6. The method of claim 1 , wherein the liquid carrier is an acetate buffer, a citrate buffer or phosphate-buffered saline.
7. The method claim 6 , wherein the composition is administered to the detect by injection.
8. A method for repairing an interarticular meniscus defect comprising the step of administering to the meniscus defect an effective amount of a composition comprising an osteogenic protein selected from the group consisting of osteogenic protein (OP)-1, OP-2, OP-3, bone morphogenetic protein (BMP)-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-9, BMP-10, BMP-11, BMP-15, BMP-3B, decapentaplegic (DPP), vegetal-1 (Vg-1), vegetal-related-1 (Vgr-1), 60A protein, growth/differentiation factor (GDF-1), GDF-5, GDF-6, GDF-9, GDF-10 and GDF-11; and a carrier selected from the group consisting of a liquid, semi-liquid and gel carrier.
9. The method of claim 8 , wherein the osteogenic protein is selected from the group consisting of OP-1, GDF-5, BMP-2, BMP-4, BMP-5 and BMP-6.
10. The method of claim 8 , wherein the osteogenic protein is OP-1.
11. The method of claim 8 , wherein the carrier is selected from the group consisting of poloxamers, gelatins, polyethylene glycols, dextrins, vegetable oils and polymers of lactic acid, butyric acid, and glycolic acid.
12. The method of claim 8 , wherein the liquid carrier is an acetate buffer, a citrate buffer or phosphate-buffered saline.
13. The method of claim 12 , wherein the composition is administered to the detect by injection.
14. A device for inducing nonarticular cartilage formation, the device consisting of an osteogenic protein selected from the group consisting of osteogenic protein (OP)-1, OP-2, OP-3, bone morphogenetic protein (BMP)-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-9, BMP-10, BMP-11, BMP-15, BMP-3B, decapentaplegic (DPP), vegetal-1 (Vg-1), vegetal-related-1 (Vgr-1), 60A protein, growth/differentiation factor (GDF-1), GDF-2, GDF-3, GDF-7, GDF-8, GDF-9, GDF-10 and GDF-11; and a carrier selected from the group consisting of a liquid and semi-liquid carrier.
15. The device of claim 14 , wherein the osteogenic protein is selected from the group consisting of OP-1, GDF-7, BMP-2, BMP-4, BMP-5 and BMP-6.
16. The device of claim 14 , wherein the osteogenic protein is OP-1.
17. The device of claim 14 , wherein the nonarticular cartilage is selected from the group consisting of fibrocartilaginous tissue, larynx, trachea, intervertebral disc, interarticular meniscus, ear, a nose and rib.
18. The device of claim 14 , wherein the carrier is selected from the group consisting of poloxamers, gelatins, polyethylene glycols, dextrins, vegetable oils and polymers of lactic acid, butyric acid, and glycolic acid.
19. The device of claim 14 , wherein the liquid carrier is an acetate buffer, a citrate buffer or phosphate-buffered saline.
20. A method for repairing a nonarticular cartilage defect in a tissue selected from the group consisting of intervertebral disc, ear, a nose and rib comprising the step of administering to the cartilage defect an effective amount of a composition comprising an osteogenic protein selected from the group consisting of osteogenic protein (OP)-1, OP-2, OP-3, bone morphogenetic protein (BMP)-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-9, BMP-10, BMP-11, BMP-15, BMP-3B, decapentaplegic (DPP), vegetal-1 (Vg-1), vegetal-related-1 (Vgr-1), 60A protein, growth/differentiation factor (GDF-1), GDF-2, GDF-3, GDF-5, GDF-6, GDF-7, GDF-8, GDF-9, GDF-10 and GDF-11; and a carrier selected from the group consisting of a liquid, semi-liquid and gel carrier.
21. The method of claim 20 , wherein the osteogenic protein is selected from the group consisting of OP-1, GDF-5; GDF-6, GDF-7, BMP-2, BMP-4, BMP-5 and BMP-6.
22. The method of claim 20 , wherein the osteogenic protein is OP-1.
23. The method of claim 20 , wherein the carrier is selected from the group consisting of poloxamers, gelatins, polyethylene glycols, dextrins, vegetable oils and polymers of lactic acid, butyric acid, and glycolic acid.
24. The method of claim 20 , wherein the liquid carrier is an acetate buffer, a citrate buffer or phosphate-buffered saline.
25. The method of claim 20 , wherein the composition is administered to the defect by injection.
26. The method of claim 20 , wherein the defect is an intervertebral disc.