Transdermal drug delivery systems comprising a coated release liner

1. A transdermal delivery device comprising a backing layer, an adhesive layer, and a release liner coated with UV-cured silicone,

wherein said adhesive layer comprises 39 weight percent (wt %) of a mineral oil, 48 wt % of polyisobutylene (PIB), 8 wt % of an active pharmaceutical ingredient, and 5 wt % of colloidal silicon dioxide (CSD),

wherein said PIB of said adhesive layer is in contact with the release liner, and

wherein said active pharmaceutical ingredient is clonidine.

2. The transdermal delivery device of claim 1 , wherein said release liner comprises a base film selected from the group consisting of polyethylene terephthalate, polypropylene, polyesters, and polyethylene.

3. The transdermal delivery device of claim 2 , wherein said base film is from about 0.5 mil to about 5 mil thick.

4. The transdermal delivery device of claim 1 , wherein said UV-cured silicone coating ranges from about 2000 angstroms to about 10,000 angstroms thick.

5. The transdermal delivery device of claim 1 , wherein said device further comprises a second adhesive layer.

6. The transdermal delivery device of claim 5 , wherein said second adhesive layer is a drug reservoir adhesive layer adjacent to said backing layer and to said adhesive layer, wherein said adhesive layer is a skin contact adhesive layer.

7. The transdermal delivery device of claim 6 , wherein an amount of active pharmaceutical ingredient in said drug reservoir adhesive layer ranges from about 1% to about 30% by weight of said drug reservoir adhesive layer.

8. The transdermal delivery device of claim 6 , further comprising a membrane or non-woven layer between said drug reservoir adhesive layer and said skin contact adhesive layer.

9. A transdermal delivery device comprising a backing layer, an adhesive layer, and a release liner coated with UV-cured silicone,

wherein said UV-cured silicone coating ranges from about 2000 angstroms to about 10,000 angstroms thick,

wherein said adhesive layer comprises 39 weight percent (wt %) of a mineral oil, 48 wt % of polyisobutylene (PIB), 5 wt % of colloidal silicon dioxide (CSD), and 8 wt % of an active pharmaceutical ingredient,

wherein said PIB of said adhesive layer is in contact with the release liner,

wherein said active pharmaceutical ingredient is clonidine, and

wherein a release force necessary to remove said coated release liner ranges from about 12 grams per inch to about 19 grams per inch.

10. The transdermal delivery device of claim 1 , wherein a peel force between the release liner and the adhesive layer ranges from 12 to 19 grams per inch (g/in).