Bone delivery device
View Patent ↗Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
1. A device comprising:
an implantable structure comprised of organic bone and micromachined to reshape a natural internal cavity thereof and to form a plurality of holes in the implantable structure that access the natural internal cavity; and
a semi-permeable component comprising a layer of confluent cells covering at least a portion of the plurality of holes of the implantable structure prior to implantation of the device into a subject.
2. The device of claim 1 , wherein the semi-permeable component at least partially surrounds one or more biologically active molecules.
3. The device of claim 2 , wherein the one or more biologically active molecules are produced by one or more living cells or tissues.
4. The device of claim 3 , wherein the one or more living cells or tissues are at least partially enclosed by the semi-permeable component.
5. The device of claim 3 , for implantation in a subject, wherein the one or more living cells or tissues are autologous, allogeneic or xenogeneic with respect to the subject.
6. The device of claim 3 , wherein the one or more living cells or tissues are genetically engineered.
7. The device of claim 2 , wherein the semi-permeable component at least partially surrounds the one or more biologically active molecules.
8. The device of claim 1 , wherein the implantable structure at least partially surrounds the semi-permeable component.
9. The device of claim 1 , wherein the semi-permeable component at least partially surrounds the implantable structure.
10. The device of claim 1 , for implantation in a subject, wherein the organic bone is autologous with respect to the subject.
11. The device of claim 2 , wherein the organic bone binds the one or more biologically active molecules.
12. The device of claim 1 , wherein the organic bone is treated to at least partially prevent restructuring.
13. The device of claim 1 , wherein the organic bone is designed to be at least partially restructured.
14. The device of claim 1 , wherein the organic bone is at least partially resorbable.
15. The device of claim 1 , for implantation in a subject, wherein the organic bone is immunogenic with respect to the subject.
16. The device of claim 1 , for implantation in a subject, wherein the organic bone is non-immunogenic with respect to the subject.
17. The device of claim 1 , wherein the organic bone is micro-machined to at least partially form an internal cavity.
18. A device comprising:
an implantable structure comprised of anorganic bone and micromachined to reshape a natural internal cavity thereof and to form a plurality of holes in the implantable structure that access the natural internal cavity; and
a semi-permeable component comprising a layer of confluent cells covering at least a portion of the plurality of holes of the implantable structure prior to implantation of the device into a subject.
19. The device of claim 18 , wherein the anorganic bone is demineralized and freeze-dried bone.
20. A device comprising:
an implantable structure for a subject comprised of allogeneic bone and micromachined to reshape a natural internal cavity thereof and to form a plurality of holes in the implantable structure that access the natural internal cavity; and
a semi-permeable component comprising a layer of confluent cells covering at least a portion of the plurality of holes of the implantable structure prior to implantation of the device into the subject.
21. The device of claim 20 , wherein the subject is an animal.
22. The device of claim 21 , wherein the animal is selected from the group consisting of a domesticated animal, a farm animal, a marine animal, a sport animal, a wild animal, a research animal, a zoo animal, a bird, an amphibian, a reptile, a fish, and a mammal.
23. The device of claim 22 , wherein the mammal is a human.
24. A device comprising:
an implantable structure for a subject comprised of xenogeneic bone and micromachined to reshape a natural internal cavity thereof and to form a plurality of holes in the implantable structure that access the natural internal cavity; and
a semi-permeable component comprising a layer of confluent cells covering at least a portion of the plurality of holes of the implantable structure prior to implantation of the device into the subject.
25. A device comprising:
an implantable structure comprised of bone and micromachined to reshape a natural internal cavity thereof and to form a plurality of holes in the implantable structure that access the natural internal cavity;
a semipermeable component comprising a layer of confluent cells covering at least a portion of the plurality of holes of the implantable structure prior to implantation of the device into a subject; and
one or more living cells or tissues genetically engineered to release one or more biologically active molecules at least partially enclosed within the semi-permeable component.
26. The device of claim 25 , wherein the semipermeable component comprises the one or more living cells or tissues genetically engineered to release the one or more biologically active molecules.