Hydroxyapatite coated nanostructured titanium surfaces
Nanotubular structured titanium (Ti) substrates have been coated with nanoparticulate hydroxyapatite (nano-HA). The nano-HA surface is highly adherent to the nanotubular Ti surface and is free of microparticles. The nano-HA coated nanotubular Ti surface promotes osteoblast cell adhesion and is particularly suitable for orthopedic and dental implants where deposition of osteoblasts and other proteins is important in bone formation.
1 . A nanostructured titanium (Ti) surface coated with nanoparticulate hydroxyapatite (HA).
2 . The Ti surface of claim 1 wherein the nanostructured surface comprises nanotubes.
3 . The Ti surface of claim 2 wherein the nanotubes are about 20-120 nm in diameter.
4 . The Ti surface of claim 2 wherein the nanotubes are about 70 nm in diameter.
5 . A method for preparing an adherent hydroxyapatite (HA) coating on a titanium (Ti) substrate, comprising:
depositing a suspension of nanoparticulate HA onto an anodized titanium surface from a molecular plasma to form a nanoHA-coated Ti substrate; and
curing the coated substrate at a temperature below sintering temperature of HA;
wherein the nanoparticulate HA coating exhibits increased adherence to the substrate compared to an uncured nanoparticulate HA coating.
6 . The method of claim 5 wherein the curing is up to about 500° C.
7 . The method of claim 5 wherein the curing is up to about 200° C.
8 . The method of claim 5 wherein the curing is conducted for about 4 to about 24 hours.
9 . The method of claim 5 wherein the cured coated substrate surface is substantially free of microparticulate HA.
10 . The method of claim 5 wherein the anodized titanium substrate comprises a nanotubular surface.
11 . A nanotubular titanium implant coated with nanoparticulate hydroxyapatite effective as a scaffold for cell deposition.
12 . The nanotubular implant of claim 11 wherein the cell is an osteoblast, fibroblast, epithelial cell or combinations thereof.
13 . The implant of claim 12 wherein the cell is an osteoblast cell.
14 . The implant of claim 12 wherein the cells adhere to the implant in vitro in physiologically compatible media.
15 . The implant of claim 11 which is a bone implant.
16 . The implant of claim 15 which is a dental bone implant.