Methods of inhibiting interleukin-17 receptor
Isolated receptors for IL-17, DNA's encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune response.
1 . A method of interfering with Interleukin-17 binding an Interleukin-17 receptor, comprising contacting an antibody that specifically binds SEQ ID NO:10 to a cell expressing a polypeptide comprising SEQ ID NO:10 in the presence of IL-17, wherein said antibody binds said polypeptide and thereby interferes with Interleukin-17 binding to and activating said Interleukin-17 receptor.
2 . The method of claim 1 , wherein said antibody specifically binds the extracellular domain of SEQ ID NO:10.
3 . The method of claim 2 , wherein said antibody specifically binds amino acids 28 through 320 of SEQ ID NO:10.
4 . The method of claims 1 - 3 , wherein said antibody is a monoclonal antibody.