Method and arrangement for monitoring an administration of at least one medication
View Patent ↗An arrangement is provided for monitoring a metering of at least one medication administered to a patient. The concentration of the active ingredient of the medication, which is measured in the breathing gas of a patient, is balanced with a computed concentration in the breathing gas. When a change of the administered quantity of the medication takes place, the concentration range ( 13 ) is adapted. The concentration, which is measured in the breathing gas, must lie by computation within this range. An arrangement for administering at least one medication and a method for monitoring a metering or dosing of the medication as well as a method for treating a patient are provided.
1. An arrangement for monitoring a dosing of a medication administered to a patient, the arrangement comprising:
an apparatus for administering the medication to said patient;
said apparatus including a device for detecting the quantity of said medication delivered to said patient;
a device for measuring the concentration of said medication in the breathing gas of said patient;
an evaluation unit for detecting a deviation of the concentration of said medication measured in said breathing gas from a first concentration range having upper and lower limits and being narrower than a second concentration range adjustable by an operator or by said evaluation unit;
said evaluation unit being adapted to determine the upper and lower limits of said first concentration range in accordance with a pharmacokinetic model based on the quantity of said medication delivered to the patient; and,
an alarm unit connected to said evaluation unit for outputting an alarm announcement when said concentration of said medication measured in said breathing gas passes out of said first concentration range thereby providing an indication of a possible malfunction in said arrangement earlier than when said concentration passes out of said second concentration range.
2. The arrangement of claim 1 , further comprising a unit for intravenously administering said medication to the patient.
3. The arrangement of claim 1 , wherein the following are included in the monitoring of said dosing: changes measured in an electroencephalogram (EEG); bispectralindex-monitoring (BIS); and, acoustically evoked potentials.
4. The arrangement of claim 1 , further comprising a measuring unit for determining the depth of anesthesia of the patient; and, said measuring unit being operatively connected to said evaluation unit.
5. The arrangement of claim 4 , wherein said measuring unit processes EEG signals obtained from the patient.
6. The arrangement of claim 1 , wherein said breathing gas flows in a breathing circuit having an inspiration branch; and, said arrangement further comprises a medication absorber disposed in said inspiration branch.
7. A method for monitoring a dosing of a medication to a patient utilizing an arrangement for monitoring said dosing, the method comprising the steps of:
administering said medication to said patient;
detecting the quantity of said medication delivered to said patient;
measuring the concentration of said medication in the breathing gas of said patient;
providing a first concentration range for said medication measured in said breathing gas in accordance with a pharmacokinetic model based on the quantity of said medication delivered to said patient;
detecting a deviation of said concentration of said medication measured in said breathing gas from said first concentration range narrower than a second concentration range adjustable by an operator; and,
outputting an alarm announcement when said concentration of said medication measured in said breathing gas passes out of said first construction range thereby providing an indication of a possible malfunction in said arrangement earlier than when said concentration passes out of said second concentration range.
8. The method of claim 7 , comprising the further step of administering said medication to the patient intravenously.
9. The method of claim 8 , comprising the further steps of:
administering said medication in the form of a bolus injection;
determining the blood concentration of said medication with pharmacokinetic computations; and,
bringing the computed blood concentration into relationship with the concentration measured in the breathing gas for an improved control.