Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto
View Patent ↗The present invention relates to the identification of neutralizing determinants on IL-17 Receptor A (IL-17RA or IL-17R) and the antigen binding proteins, such as antibodies, that bind thereto and inhibit IL-17 ligand family members from binding to and activating IL-17 Receptor A or a receptor complex comprising IL-17 Receptor A.
1. An isolated monoclonal antibody, comprising a first isolated monoclonal antibody, or IL-17RA-binding fragment thereof, that specifically binds to IL-17RA and competes for binding with a second isolated monoclonal antibody, wherein said second isolated monoclonal antibody, or IL-17RA-binding fragment thereof, comprises a light chain CDR1 (SEQ ID NO:224), CDR2 (SEQ ID NO:225), CDR3 (SEQ ID NO:226) and a heavy chain CDR1 (SEQ ID NO:146), CDR2 (SEQ ID NO:147), CDR3 (SEQ ID NO:148).
2. The first isolated monoclonal antibody of claim 1 , wherein said first isolated monoclonal antibody is selected from the group consisting of:
a. a human antibody;
b. a humanized antibody;
c. a chimeric antibody;
d. a single chain antibody;
e. a diabody;
f. a triabody;
g. a tetrabody;
h. a Fab fragment;
i. a F(ab′)2 fragment;
j. an IgD antibody;
k. an IgE antibody;
l. an IgM antibody;
m. an IgG1 antibody;
n. an IgG2 antibody;
o. an IgG3 antibody; and
p. an IgG4 antibody.
3. The first isolated monoclonal antibody of claim 2 , wherein said antibody inhibits human IL-17A from binding to human IL-17RA.
4. The first isolated monoclonal antibody of claim 3 , wherein said antibody inhibits human IL-17A and human IL-17F from binding to human IL-17RA.
5. The first isolated monoclonal antibody of claim 2 , wherein said antibody inhibits human IL-17A or human IL-17F from binding to human IL-17RA.
6. An isolated monoclonal antibody, comprising a first isolated monoclonal antibody, or IL-17RA-binding fragment thereof, that specifically binds to IL-17RA and competes for binding with a second isolated monoclonal antibody, wherein said second isolated monoclonal antibody, or IL-17RA-binding fragment thereof, comprises a light chain variable domain sequence comprising SEQ ID NO:40 and a heavy chain variable domain sequence comprising SEQ ID NO:14.
7. An isolated monoclonal antibody, comprising a first isolated monoclonal antibody, or IL-17RA-binding fragment thereof, that specifically binds to IL-17RA and competes for binding with a second isolated monoclonal antibody, wherein said second isolated monoclonal antibody, or IL-17RA-binding fragment thereof, comprises a light chain sequence comprising SEQ ID NO:429 and a heavy chain sequence comprising SEQ ID NO:427.
8. An isolated monoclonal antibody, comprising a first isolated monoclonal antibody, or IL-17RA-binding fragment thereof, that specifically binds to IL-17RA and competes for binding with a second isolated monoclonal antibody, wherein said second isolated monoclonal antibody, or IL-17RA-binding fragment thereof, comprises at least two light chain sequences comprising SEQ ID NO:429 and at least two heavy chain sequences comprising SEQ ID NO:427.