Process for production of 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propyl)azetidin-3-ol or salts thereof
A Process for production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which comprises using as a starting compound as a (phenylthio)acetic acid derivative or salts thereof represented by the general formula: wherein X 1 represents a halogen atom, is useful as a safe process for mass production of 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which is useful as a remedy for disease of central and peripheral nerve.
1. A propionic acid ester compound represented by formula (I):
wherein R 1 represents a hydrogen atom or alkyl, cycloalkyl, or aryl group, which are each unsubstituted or substituted with at least one substituent selected from the group consisting of a halogen atom, a hydroxyl group, a nitro group, an alkyl group, a cycloalkyl group, an alkoxy group, an alkenyl group, and an aryl group.
2. The propionic acid ester compound of claim 1 , wherein R 1 is an alkyl group.
3. The propionic acid ester compound of claim 1 , wherein R 1 is a cycloalkyl group.
4. The propionic acid ester compound of claim 1 , wherein R 1 is an aryl group.
5. The propionic acid ester compound of claim 2 , wherein the alkyl group is substituted with a halogen.
6. The propionic acid ester compound of claim 3 , wherein the cycloalkyl group is substituted with a halogen.
7. The propionic acid ester compound of claim 4 , wherein the aryl group is substituted with a halogen.
8. The propionic acid ester compound of claim 2 , wherein the alkyl group is substituted with an alkenyl group.
9. The propionic acid ester compound of claim 3 , wherein the cycloalkyl group is substituted with an alkenyl group.
10. The propionic acid ester compound of claim 4 , wherein the aryl group is substituted with an alkenyl group.
11. The propionic acid ester compound of claim 2 , wherein the alkyl group is substituted with an alkoxy group.
12. The propionic acid ester compound of claim 3 , wherein the cycloalkyl group is substituted with an alkoxy group.
13. The propionic acid ester compound of claim 4 , wherein the aryl group is substituted with an alkoxy group.
14. The propionic acid ester compound of claim 2 , wherein the alkyl group is substituted with an alkyl group.
15. The propionic acid ester compound of claim 3 , wherein the cycloalkyl group is substituted with an alkyl group.
16. The propionic acid ester compound of claim 4 , wherein the aryl group is substituted with an alkyl group.
17. The propionic acid ester compound of claim 2 , wherein the alkyl group is substituted with an aryl group.
18. The propionic acid ester compound of claim 3 , wherein the cycloalkyl group is substituted with an aryl group.
19. The propionic acid ester compound of claim 4 , wherein the aryl group is substituted with an aryl group.
20. The propionic acid ester compound of claim 1 , having structure (II):
21. The propionic acid ester compound of claim 1 , having structure (III):