Use of a sulfonamide compound for improving the pharmacokinetics of a drug
View Patent ↗A method for improving the pharmacokinetics of drugs, which are metabolized by cytochrome P450 monooxygenase is disclosed. More specifically it relates to a method for improving the pharmacokinetics of retroviral protease inhibitors and in particular for improving the pharmacokinetics of human immunodeficiency virus (HIV) protease inhibitors. A pharmaceutical composition and its use in the manufacture of a medicament for the inhibition or treatment of an HIV infection or AIDS in a human being are also part of the invention.
1. A method of improving the pharmacokinetics of HIV-aspartyl protease inhibitor drug darunavir or saquinavir metabolized by cytochrome P450, or inhibited by P-glycoprotein, MRP1 or MRP2 activity by administering an effective amount of a compound having the formula
or a compound having the formula
to a mammal in need of such improvement.