Method for producing indazol-3-ylmethyl phosphonium salt
View Patent ↗The present invention provides a method for producing an indazol-3-ylmethyl phosphonium salt represented by Formula (IV): [wherein X represents halogen, OSO 2 R a (wherein R a represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl or the like), or OC(═O)R b (wherein R b has the same meaning as the above R a ), or the like, and R 1 , R 2 and R 3 may be the same or different and each represents substituted or unsubstituted aryl or the like] or a salt thereof, which comprises reacting a compound represented by Formula (I): a compound represented by Formula (II): H—X (II) (wherein X has the same meaning as defined above), and a compound represented by Formula (III): (wherein R 1 , R 2 and R 3 have the same meanings as defined above, respectively), and the like.
1. A method for producing an indazol-3-ylmethyl phosphonium salt represented by Formula (IV):
[wherein, X represents halogen, ONO 2 , OSO 3 H, OSO 2 R a (wherein R a represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or a substituted or unsubstituted aromatic heterocyclic group), or OC(═O)R b (wherein R b has the same meaning as the above R a ), and R 1 , R 2 and R 3 may be the same or different and each represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group] or a salt thereof, which comprises reacting a compound represented by Formula (I):
a compound represented by Formula (II):
H—X (II),
and a compound represented by Formula (III):
2. The method for producing an indazol-3-ylmethyl phosphonium salt or a salt thereof according to claim 1 , wherein R 1 , R 2 and R 3 may be the same or different and each represents substituted or unsubstituted aryl.
3. The method for producing an indazol-3-ylmethyl phosphonium salt or a salt thereof according to claim 1 , wherein R 1 , R 2 and R 3 are phenyl.
4. The method for producing an indazol-3-ylmethyl phosphonium salt or a salt thereof according to any of claims 1 to 3 , wherein X is halogen.
5. The method for producing an indazol-3-ylmethyl phosphonium salt or a salt thereof according to any of claims 1 to 3 , wherein X is ONO 2 , OSO 3 H, OSO 2 R a , or OC(═O)R b .
6. The method for producing an indazol-3-ylmethyl phosphonium salt or a salt thereof according to any of claims 1 to 3 , wherein X is OSO 2 R a .
7. The method for producing an indazol-3-ylmethyl phosphonium salt or a salt thereof according to any of claims 1 to 3 , wherein X is OC(═O)R b .
8. A method for producing an indazole derivative represented by Formula (V):
(wherein, Ar represents substituted or unsubstituted aryl, or a substituted or unsubstituted heterocyclic group) or a salt thereof, which comprises a step of reacting a compound represented by Formula (I):
a compound represented by Formula (II):
H—X (II)
(wherein X represents halogen, ONO 2 , OSO 3 H, OSO 2 R a (wherein R a represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or a substituted or unsubstituted aromatic heterocyclic group), or OC(═O)R b (wherein R b has the same meaning as the above R a )) and a compound represented by Formula (III):
(wherein R 1 , R 2 and R 3 may be the same or different and each represents substituted or unsubstituted aryl or a substituted or unsubstituted aromatic heterocyclic group) to obtain an indazol-3-ylmethyl phosphonium salt represented by Formula (IV):
or a salt thereof.
9. The method for producing an indazole derivative or a salt thereof according to claim 8 , wherein Ar is substituted or unsubstituted aryl.
10. The method for producing an indazole derivative or a salt thereof according to claim 8 , wherein Ar is substituted or unsubstituted phenyl.
11. The method for producing an indazole derivative or a salt thereof according to claim 8 , wherein Ar is a substituted or unsubstituted aromatic heterocyclic group.