Erythropoietin-derived short peptide and its mimics as immuno/inflammatory modulators
The present invention provides isolated stabilized EPO-derived peptides and their mimics that protect against tissue damage in subjects having diverse forms of neural and non-neural organ system injury, pharmaceutical compositions containing the isolated stabilized EPO-derived peptides, methods for treating symptoms of a disease, disorder or condition having an inflammatory or an autoimmune component in a subject in need thereof, and methods for downregulating immune mediator activity in a subject in need thereof.
1. An isolated peptide consisting of the amino acid sequence of SEQ ID NO: 7.
2. A pharmaceutical composition comprising the isolated peptide of claim 1 .
3. The pharmaceutical composition of claim 2 , further comprising a pharmaceutically acceptable carrier and wherein the peptide is present in an effective amount.
4. A pharmaceutical composition comprising a pharmaceutically acceptable carrier, an effective amount of an isolated peptide consisting of the amino acid sequence of SEQ ID NO: 7, and an effective amount of an isolated peptide consisting of the amino acid sequence of SEQ ID NO: 9.
5. An isolated peptide consisting of the amino acid sequence of SEQ ID NO: 9.
6. A pharmaceutical composition comprising the isolated peptide of claim 5 .
7. The pharmaceutical composition of claim 6 , further comprising a pharmaceutically acceptable carrier and wherein the peptide is present in an effective amount.